Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus

Airway mucus is a major barrier to the delivery of lipid‐based nanoparticles in chronic airway diseases such as cystic fibrosis (CF). Receptor‐Targeted Nanocomplexes (RTN), comprise mixtures of cationic lipids and bifunctional peptides with receptor‐targeting and nucleic acid packaging properties. T...

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Veröffentlicht in:	Advanced healthcare materials 2025-01, Vol.14 (1), p.e2400510-n/a
Hauptverfasser:	Maeshima, Ruhina, Tagalakis, Aristides D., Gyftaki‐Venieri, Dafni, Jones, Stuart A., Rye, Philip D., Tøndervik, Anne, Åstrand, O. Alexander H., Hart, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates Alginates - chemistry Alginic acid Cations Cations - chemistry Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - metabolism Diffusion Diffusion barriers Diffusion coating Diffusion rate Electron microscopy Electrons Humans Lipids Low molecular weights Molecular Weight mRNA Mucus Mucus - metabolism mucus penetration Nanoparticles Nanoparticles - chemistry Nucleic acids Oligosaccharides Oligosaccharides - chemistry Peptides Polyethylene glycol Polyethylene Glycols - chemistry Receptors Respiratory tract diseases Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - chemistry siRNA Transfection Transfection - methods
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