Model‐based interspecies interpretation of botulinum neurotoxin type A on muscle‐contraction inhibition

Botulinum neurotoxins (BoNTs) are commonly used in therapeutic and cosmetic applications. One such neurotoxin, BoNT type A (BoNT/A), has been studied widely for its effects on muscle function and contraction. Despite the importance of BoNT/A products, determining the blood concentrations of these to...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2024-12, Vol.45 (4-6), p.190-200
Hauptverfasser:	Ryu, Hyo‐jeong, Kwak, Seongsung, Park, Misun, Yun, Hwi‐yeol
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Animal models Animals botulinum neurotoxin type A Botulinum toxin Botulinum Toxins, Type A - pharmacokinetics Botulinum Toxins, Type A - pharmacology Female kinetic‐pharmacodynamic (K‐PD) model Medical research Mice Models, Biological Muscle contraction Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism muscle‐contraction inhibition Neuromuscular Agents - pharmacokinetics Neuromuscular Agents - pharmacology Neurotoxins Original pharmacodynamic Pharmacodynamics pharmacokinetic Pharmacokinetics Rats Rats, Sprague-Dawley Species Specificity
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