Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study

Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more ef...

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Veröffentlicht in:	BMC cancer 2024-12, Vol.24 (1), p.1592, Article 1592
Hauptverfasser:	Kahraman, Seda, Hizal, Mutlu, Demirel, Burcin Cakan, Guven, Deniz Can, Gumusay, Ozge, Uluc, Basak Oyan, Bayram, Ertugrul, Gulbagci, Burcu, Yasar, Alper, Davarci, Sena Ece, Mocan, Eda Eylemer, Acar, Omer, Isik, Deniz, Aydin, Esra, Karakas, Yusuf, Ozcelik, Melike, Keser, Murat, Okutur, Sadi Kerem, Eren, Onder, Menekse, Serkan, Aydin, Dincer, Yilmaz, Funda, Dogan, Ozlem, Ozkanli, Gulhan, Yucel, Hakan, Sunar, Veli, Aykan, Musa Baris, Ozdemir, Ozlem, Duman, Berna Bozkurt, Keskinkilic, Merve, Sakalar, Teoman, Inal, Ali, Karaoglanoglu, Muge, Aksoy, Asude, Er, Muhammed Muhiddin, Turhal, Nazim Serdar, Kalkan, Nurhan Onal, Sendur, Mehmet Ali Nahit
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged patients Aged, 80 and over Aminopyridines - administration & dosage Aminopyridines - adverse effects Aminopyridines - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer patients Care and treatment Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - antagonists & inhibitors Drug therapy Drug therapy, Combination Female Fulvestrant Humans Medical research Medicine, Experimental Metastasis Patient outcomes Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Purines - administration & dosage Purines - adverse effects Purines - therapeutic use Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Retrospective Studies Turkey - epidemiology
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