Factors affecting fatigue progression in multiple sclerosis patients
Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens th...
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| Veröffentlicht in: | Scientific reports 2024-12, Vol.14 (1), p.31682, Article 31682 |
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| creator | Machtoub, Dima Fares, Callie Sinan, Hassan Al Hariri, Moustafa Nehme, Rim Chami, Joelle Joukhdar, Ronny Tcheroyan, Raya Adib, Salim Khoury, Samia J. |
| description | Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life. |
| doi_str_mv | 10.1038/s41598-024-80992-0 |
| format | Article |
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This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-80992-0</identifier><identifier>PMID: 39738166</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/477/2811 ; 692/699/375/1666 ; Adult ; Antidepressants ; Antidepressive Agents - therapeutic use ; Depression - drug therapy ; Depression - etiology ; Disease Progression ; Fatigue ; Fatigue - etiology ; Female ; Humanities and Social Sciences ; Humans ; Male ; Mental depression ; Middle Aged ; multidisciplinary ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - drug therapy ; Pain ; Pain - drug therapy ; Pain - etiology ; Quality of Life ; Retrospective Studies ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2024-12, Vol.14 (1), p.31682, Article 31682</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>Copyright Nature Publishing Group 2024</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2270-d1a64a4399e87a98897fc55ab4f2650f7560ffc206dc1a09b3dbcbbd3b1e98bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686268/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686268/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39738166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machtoub, Dima</creatorcontrib><creatorcontrib>Fares, Callie</creatorcontrib><creatorcontrib>Sinan, Hassan</creatorcontrib><creatorcontrib>Al Hariri, Moustafa</creatorcontrib><creatorcontrib>Nehme, Rim</creatorcontrib><creatorcontrib>Chami, Joelle</creatorcontrib><creatorcontrib>Joukhdar, Ronny</creatorcontrib><creatorcontrib>Tcheroyan, Raya</creatorcontrib><creatorcontrib>Adib, Salim</creatorcontrib><creatorcontrib>Khoury, Samia J.</creatorcontrib><title>Factors affecting fatigue progression in multiple sclerosis patients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life.</description><subject>631/477/2811</subject><subject>692/699/375/1666</subject><subject>Adult</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Depression - drug therapy</subject><subject>Depression - etiology</subject><subject>Disease Progression</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - drug therapy</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kclKxTAUhoMoKtf7Ai6k4MZNNUOTJisRZxDc6DqkaVIjbVOTVvDtjbfXcWE2J3C-85_hB2AfwWMECT-JBaKC5xAXOYdC4BxugF0MC5pjgvHmj_8OWMb4DNOjWBRIbIMdIkrCEWO74OJK6dGHmClrjR5d32RWja6ZTDYE3wQTo_N95vqsm9rRDa3Jom5N8NHFbEik6ce4B7asaqNZruMCPF5dPpzf5Hf317fnZ3e5xriEeY0UK1RBhDC8VIJzUVpNqaoKixmFtqQMWqsxZLVGCoqK1JWuqppUyAheWbIAp7PuMFWdqXXqHVQrh-A6Fd6kV07-zvTuSTb-VSLEOMOMJ4WjtULwL5OJo-xc1KZtVW_8FCVBFJKCEVQm9PAP-uyn0Kf9VhQSlFCUKDxTOp0kBmO_pkFQfhglZ6NkMkqujJIwFR383OOr5NOWBJAZiCnVNyZ89_5H9h1uIp9v</recordid><startdate>20241230</startdate><enddate>20241230</enddate><creator>Machtoub, Dima</creator><creator>Fares, Callie</creator><creator>Sinan, Hassan</creator><creator>Al Hariri, Moustafa</creator><creator>Nehme, Rim</creator><creator>Chami, Joelle</creator><creator>Joukhdar, Ronny</creator><creator>Tcheroyan, Raya</creator><creator>Adib, Salim</creator><creator>Khoury, Samia J.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241230</creationdate><title>Factors affecting fatigue progression in multiple sclerosis patients</title><author>Machtoub, Dima ; Fares, Callie ; Sinan, Hassan ; Al Hariri, Moustafa ; Nehme, Rim ; Chami, Joelle ; Joukhdar, Ronny ; Tcheroyan, Raya ; Adib, Salim ; Khoury, Samia J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2270-d1a64a4399e87a98897fc55ab4f2650f7560ffc206dc1a09b3dbcbbd3b1e98bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>631/477/2811</topic><topic>692/699/375/1666</topic><topic>Adult</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machtoub, Dima</au><au>Fares, Callie</au><au>Sinan, Hassan</au><au>Al Hariri, Moustafa</au><au>Nehme, Rim</au><au>Chami, Joelle</au><au>Joukhdar, Ronny</au><au>Tcheroyan, Raya</au><au>Adib, Salim</au><au>Khoury, Samia J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting fatigue progression in multiple sclerosis patients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2024-12-30</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>31682</spage><pages>31682-</pages><artnum>31682</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39738166</pmid><doi>10.1038/s41598-024-80992-0</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/477/2811 692/699/375/1666 Adult Antidepressants Antidepressive Agents - therapeutic use Depression - drug therapy Depression - etiology Disease Progression Fatigue Fatigue - etiology Female Humanities and Social Sciences Humans Male Mental depression Middle Aged multidisciplinary Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - drug therapy Pain Pain - drug therapy Pain - etiology Quality of Life Retrospective Studies Science Science (multidisciplinary) |
| title | Factors affecting fatigue progression in multiple sclerosis patients |
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