Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage
Hydrocephalus commonly occurs after subarachnoid hemorrhage (SAH) and is associated with increased morbidity and disability in patients with SAH. Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fib...
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| creator | Deng, Xuehai Ding, Jianlin Liu, Chang Wang, Zhong Wang, Junchi Duan, Qiyue Li, Weida Chen, Xinlong Tang, Xiaoping Zhao, Long |
| description | Hydrocephalus commonly occurs after subarachnoid hemorrhage (SAH) and is associated with increased morbidity and disability in patients with SAH. Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. Although the mechanisms of hydrocephalus after SAH are increasingly being revealed, the clinical prognosis of SAH still has not improved significantly. Further research on SAH is needed to reveal the underlying mechanisms of hydrocephalus and develop translatable therapies. A model that can stably mimic the histopathological and neuroethological features of hydrocephalus is critical for animal experiments. There have been fewer animal studies on hydrocephalus after SAH than on other stroke subtypes. The development of a reproducible and effective model of hydrocephalus after SAH is essential. In this study, we establish a mouse model of SAH that stably mimics brain injury and hydrocephalus after SAH through injections of autologous blood into the cisterna magna via different methods and characterize the model in terms of neurological behavior, histology, imaging, neuronal damage, and white matter damage. |
| doi_str_mv | 10.1038/s41598-024-82843-4 |
| format | Article |
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Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. Although the mechanisms of hydrocephalus after SAH are increasingly being revealed, the clinical prognosis of SAH still has not improved significantly. Further research on SAH is needed to reveal the underlying mechanisms of hydrocephalus and develop translatable therapies. A model that can stably mimic the histopathological and neuroethological features of hydrocephalus is critical for animal experiments. There have been fewer animal studies on hydrocephalus after SAH than on other stroke subtypes. The development of a reproducible and effective model of hydrocephalus after SAH is essential. In this study, we establish a mouse model of SAH that stably mimics brain injury and hydrocephalus after SAH through injections of autologous blood into the cisterna magna via different methods and characterize the model in terms of neurological behavior, histology, imaging, neuronal damage, and white matter damage.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-82843-4</identifier><identifier>PMID: 39738570</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/617/375/1370 ; 692/617/375/240 ; 692/617/375/365 ; 692/617/375/380 ; 692/617/375/534 ; Animal model ; Animals ; Arachnoiditis ; Behavior, Animal ; Brain injury ; Cerebrospinal fluid ; Choroid plexus ; Disease Models, Animal ; Fibrosis ; Histology ; Humanities and Social Sciences ; Hydrocephalus ; Hydrocephalus - etiology ; Hydrocephalus - pathology ; Male ; Mice ; Mice, Inbred C57BL ; Morbidity ; Mouse ; multidisciplinary ; Neuroethology ; Neuroimaging ; Neuronal apoptosis ; Science ; Science (multidisciplinary) ; Stroke ; Subarachnoid hemorrhage ; Subarachnoid Hemorrhage - complications ; Subarachnoid Hemorrhage - pathology ; Substantia alba ; White matter damage</subject><ispartof>Scientific reports, 2024-12, Vol.14 (1), p.31794-16, Article 31794</ispartof><rights>The Author(s) 2024</rights><rights>2024. 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Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. Although the mechanisms of hydrocephalus after SAH are increasingly being revealed, the clinical prognosis of SAH still has not improved significantly. Further research on SAH is needed to reveal the underlying mechanisms of hydrocephalus and develop translatable therapies. A model that can stably mimic the histopathological and neuroethological features of hydrocephalus is critical for animal experiments. There have been fewer animal studies on hydrocephalus after SAH than on other stroke subtypes. The development of a reproducible and effective model of hydrocephalus after SAH is essential. In this study, we establish a mouse model of SAH that stably mimics brain injury and hydrocephalus after SAH through injections of autologous blood into the cisterna magna via different methods and characterize the model in terms of neurological behavior, histology, imaging, neuronal damage, and white matter damage.</description><subject>692/617/375/1370</subject><subject>692/617/375/240</subject><subject>692/617/375/365</subject><subject>692/617/375/380</subject><subject>692/617/375/534</subject><subject>Animal model</subject><subject>Animals</subject><subject>Arachnoiditis</subject><subject>Behavior, Animal</subject><subject>Brain injury</subject><subject>Cerebrospinal fluid</subject><subject>Choroid plexus</subject><subject>Disease Models, Animal</subject><subject>Fibrosis</subject><subject>Histology</subject><subject>Humanities and Social Sciences</subject><subject>Hydrocephalus</subject><subject>Hydrocephalus - etiology</subject><subject>Hydrocephalus - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Morbidity</subject><subject>Mouse</subject><subject>multidisciplinary</subject><subject>Neuroethology</subject><subject>Neuroimaging</subject><subject>Neuronal apoptosis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Stroke</subject><subject>Subarachnoid hemorrhage</subject><subject>Subarachnoid Hemorrhage - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Xuehai</au><au>Ding, Jianlin</au><au>Liu, Chang</au><au>Wang, Zhong</au><au>Wang, Junchi</au><au>Duan, Qiyue</au><au>Li, Weida</au><au>Chen, Xinlong</au><au>Tang, Xiaoping</au><au>Zhao, Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2024-12-30</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>31794</spage><epage>16</epage><pages>31794-16</pages><artnum>31794</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Hydrocephalus commonly occurs after subarachnoid hemorrhage (SAH) and is associated with increased morbidity and disability in patients with SAH. Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. Although the mechanisms of hydrocephalus after SAH are increasingly being revealed, the clinical prognosis of SAH still has not improved significantly. Further research on SAH is needed to reveal the underlying mechanisms of hydrocephalus and develop translatable therapies. A model that can stably mimic the histopathological and neuroethological features of hydrocephalus is critical for animal experiments. There have been fewer animal studies on hydrocephalus after SAH than on other stroke subtypes. The development of a reproducible and effective model of hydrocephalus after SAH is essential. In this study, we establish a mouse model of SAH that stably mimics brain injury and hydrocephalus after SAH through injections of autologous blood into the cisterna magna via different methods and characterize the model in terms of neurological behavior, histology, imaging, neuronal damage, and white matter damage.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39738570</pmid><doi>10.1038/s41598-024-82843-4</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/617/375/1370 692/617/375/240 692/617/375/365 692/617/375/380 692/617/375/534 Animal model Animals Arachnoiditis Behavior, Animal Brain injury Cerebrospinal fluid Choroid plexus Disease Models, Animal Fibrosis Histology Humanities and Social Sciences Hydrocephalus Hydrocephalus - etiology Hydrocephalus - pathology Male Mice Mice, Inbred C57BL Morbidity Mouse multidisciplinary Neuroethology Neuroimaging Neuronal apoptosis Science Science (multidisciplinary) Stroke Subarachnoid hemorrhage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - pathology Substantia alba White matter damage |
| title | Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage |
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