Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease

The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2024-12, Vol.15 (1), p.10788, Article 10788
Hauptverfasser:	Li, Zhen, Gu, Min, Zaparte, Aline, Fu, Xiaoming, Mahen, Kala, Mrdjen, Marko, Li, Xinmin S., Yang, Zhihong, Ma, Jing, Thoudam, Themis, Chandler, Kristina, Hesler, Maggie, Heathers, Laura, Gorse, Kiersten, Van, Thanh Trung, Wong, David, Gibson, Aaron M., Wang, Zeneng, Taylor, Christopher M., Quijada, Pearl, Makarewich, Catherine A., Hazen, Stanley L., Liangpunsakul, Suthat, Brown, J. Mark, Lefer, David J., Welsh, David A., Sharp, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/34 14/5 45/77 45/91 631/326/2565/2134 631/443/592/75 64/60 692/499 82/1 82/29 82/58 82/80 96/63 Alcohol Alcoholism - metabolism Alcohols Animals Cardiomyocytes Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - microbiology Cell activation Disease Models, Animal Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Ethanol - metabolism Ethanol - pharmacology Fecal Microbiota Transplantation Fecal microflora Female Gastrointestinal Microbiome - drug effects Glutamates - metabolism Glutamine - analogs & derivatives Glutamine - metabolism Heart diseases Humanities and Social Sciences Humans Male Males Metabolites Mice Mice, Inbred C57BL Microbiota Microorganisms Middle Aged multidisciplinary Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidative stress Oxidative Stress - drug effects Phenotypes Science Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!