Harnessing synthetic biology to engineer organoids and tissues
The development of an organism depends on intrinsic genetic programs of progenitor cells and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids from progenitor cells provides a platform for recapitulating and exploring development. Current approaches rely largely o...
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| Veröffentlicht in: | Cell stem cell 2023-01, Vol.30 (1), p.10-19 |
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| container_title | Cell stem cell |
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| creator | Trentesaux, Coralie Yamada, Toshimichi Klein, Ophir D Lim, Wendell A |
| description | The development of an organism depends on intrinsic genetic programs of progenitor cells and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids from progenitor cells provides a platform for recapitulating and exploring development. Current approaches rely largely on soluble morphogens or engineered biomaterials to manipulate the physical environment, but the emerging field of synthetic biology provides a powerful toolbox to genetically manipulate cell communication, adhesion, and even cell fate. Applying these modular tools to organoids should lead to a deeper understanding of developmental principles, improved organoid models, and an enhanced capability to design tissues for regenerative purposes. |
| doi_str_mv | 10.1016/j.stem.2022.12.013 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1934-5909 |
| ispartof | Cell stem cell, 2023-01, Vol.30 (1), p.10-19 |
| issn | 1934-5909 1875-9777 1875-9777 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11684341 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biocompatible Materials Cell Differentiation Organoids Stem Cells Synthetic Biology |
| title | Harnessing synthetic biology to engineer organoids and tissues |
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