Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia
This study aimed to investigate the association of IL-6 with steatotic liver disease (SLD) and liver fibrosis (LF) in rheumatoid arthritis (RA) patients at a rheumatology center in Cartagena de Indias, Colombia. This was a cross-sectional study that included RA and non-RA cases. The level of cellula...
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| Veröffentlicht in: | Genes 2024-12, Vol.15 (12), p.1639 |
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| creator | Pérez-Mingan, Gloria Caterine Sierra-Merlano, Rita Magola Yepes, Ismael Vergara, María Judith Palomino Ortiz, Miguel Peña, Breiner Cano-Pérez, Eder Gómez-Camargo, Doris |
| description | This study aimed to investigate the association of IL-6 with steatotic liver disease (SLD) and liver fibrosis (LF) in rheumatoid arthritis (RA) patients at a rheumatology center in Cartagena de Indias, Colombia.
This was a cross-sectional study that included RA and non-RA cases. The level of cellular expression of interleukin 6 (IL-6) was evaluated by flow cytometry in peripheral blood leukocytes, and the presence of SLD and LF was detected by elastosonography. The main outcome was to establish the association between the levels of cellular expression of IL-6 and the development of SLD and LF.
This study included 47 cases of RA and 34 cases on-RA, with a mean age of 54 and 55 years, respectively. The frequency of SLD was 55.3% in RA and 38.2% in non-RA. The frequency of LF was 12.8% in RA and 14.7% in non-RA, with no statistical difference. The levels of cellular expression of IL-6 were significantly higher in RA compared to non-RA. Cellular expression of IL-6 was associated with the presence of SLD (54% vs. 30.3%;
= 0.002). This association was not maintained in RA cases (49.5% vs. 47.6%;
= 0.571). No association was found between cellular expression of IL-6 and LF in the total population (43.8% vs. 42.7%;
= 0.813) nor in RA cases (59.41% vs. 48.3%;
= 0.526).
IL-6 levels were related to SLD in the evaluated sample, and RA was not a risk factor for SLD or LF. The prognostic role of IL-6 for SLD in patients with RA requires further studies. |
| doi_str_mv | 10.3390/genes15121639 |
| format | Article |
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This was a cross-sectional study that included RA and non-RA cases. The level of cellular expression of interleukin 6 (IL-6) was evaluated by flow cytometry in peripheral blood leukocytes, and the presence of SLD and LF was detected by elastosonography. The main outcome was to establish the association between the levels of cellular expression of IL-6 and the development of SLD and LF.
This study included 47 cases of RA and 34 cases on-RA, with a mean age of 54 and 55 years, respectively. The frequency of SLD was 55.3% in RA and 38.2% in non-RA. The frequency of LF was 12.8% in RA and 14.7% in non-RA, with no statistical difference. The levels of cellular expression of IL-6 were significantly higher in RA compared to non-RA. Cellular expression of IL-6 was associated with the presence of SLD (54% vs. 30.3%;
= 0.002). This association was not maintained in RA cases (49.5% vs. 47.6%;
= 0.571). No association was found between cellular expression of IL-6 and LF in the total population (43.8% vs. 42.7%;
= 0.813) nor in RA cases (59.41% vs. 48.3%;
= 0.526).
IL-6 levels were related to SLD in the evaluated sample, and RA was not a risk factor for SLD or LF. The prognostic role of IL-6 for SLD in patients with RA requires further studies.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes15121639</identifier><identifier>PMID: 39766906</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Arthritis ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Blood ; Body mass index ; Colombia - epidemiology ; Cross-Sectional Studies ; Cytokines ; Ethylenediaminetetraacetic acid ; Fatty liver ; Fatty Liver - pathology ; Female ; Fibrosis ; Flow cytometry ; Humans ; Hypothesis testing ; Informed consent ; Insulin resistance ; Interleukin 6 ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Interleukins ; Leukocytes ; Liver ; Liver cirrhosis ; Liver Cirrhosis - pathology ; Liver diseases ; Male ; Medical records ; Medical research ; Medicine, Experimental ; Metabolism ; Middle Aged ; Pathogenesis ; Peripheral blood ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Risk factors ; Steatosis</subject><ispartof>Genes, 2024-12, Vol.15 (12), p.1639</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-3f3f6cde9ccf711fa974d7475c187e20f3cd83ed857c7e64a8a95a54104aaba33</cites><orcidid>0000-0002-2443-6891 ; 0000-0002-7243-4065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39766906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Mingan, Gloria Caterine</creatorcontrib><creatorcontrib>Sierra-Merlano, Rita Magola</creatorcontrib><creatorcontrib>Yepes, Ismael</creatorcontrib><creatorcontrib>Vergara, María Judith Palomino</creatorcontrib><creatorcontrib>Ortiz, Miguel</creatorcontrib><creatorcontrib>Peña, Breiner</creatorcontrib><creatorcontrib>Cano-Pérez, Eder</creatorcontrib><creatorcontrib>Gómez-Camargo, Doris</creatorcontrib><title>Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>This study aimed to investigate the association of IL-6 with steatotic liver disease (SLD) and liver fibrosis (LF) in rheumatoid arthritis (RA) patients at a rheumatology center in Cartagena de Indias, Colombia.
This was a cross-sectional study that included RA and non-RA cases. The level of cellular expression of interleukin 6 (IL-6) was evaluated by flow cytometry in peripheral blood leukocytes, and the presence of SLD and LF was detected by elastosonography. The main outcome was to establish the association between the levels of cellular expression of IL-6 and the development of SLD and LF.
This study included 47 cases of RA and 34 cases on-RA, with a mean age of 54 and 55 years, respectively. The frequency of SLD was 55.3% in RA and 38.2% in non-RA. The frequency of LF was 12.8% in RA and 14.7% in non-RA, with no statistical difference. The levels of cellular expression of IL-6 were significantly higher in RA compared to non-RA. Cellular expression of IL-6 was associated with the presence of SLD (54% vs. 30.3%;
= 0.002). This association was not maintained in RA cases (49.5% vs. 47.6%;
= 0.571). No association was found between cellular expression of IL-6 and LF in the total population (43.8% vs. 42.7%;
= 0.813) nor in RA cases (59.41% vs. 48.3%;
= 0.526).
IL-6 levels were related to SLD in the evaluated sample, and RA was not a risk factor for SLD or LF. The prognostic role of IL-6 for SLD in patients with RA requires further studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Blood</subject><subject>Body mass index</subject><subject>Colombia - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fatty liver</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Flow cytometry</subject><subject>Humans</subject><subject>Hypothesis testing</subject><subject>Informed consent</subject><subject>Insulin resistance</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukins</subject><subject>Leukocytes</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Peripheral blood</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Steatosis</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkk1v1DAQhiMEolXpkSuyxIUDKXac2MkJrSL6Ia2EVOBszTqTjUtiL7ZT1P_BD65Dy9JF2AfbM8_M-LUny14zesZ5Qz9s0WJgFSuY4M2z7LigkudlWVTPn-yPstMQbmgaJS0orV5mR7yRQjRUHGe_rnGEaJwNg9kR15MrG9GPOH83lgjy08SBXOIuIZp8iQjRBRMI2I6szS16cm42_rcp4dcDzlMiTEdWPg7exAWNBPae0W3vSAseSYtLnSUqHSMkIfCetAmYNgZeZS96GAOePq4n2bfzT1_by3z9-eKqXa1zzTmNOe95L3SHjda9ZKyHRpadLGWlWS2xoD3XXc2xqyupJYoSamgqqEpGS4ANcH6SfXzIu5s3E3Y63cnDqHbeTODvlAOjDj3WDGrrbhVjQlaSFinDu8cM3v2YMUQ1maBxHMGim4PirOK1kKKQCX37D3rjZm-TvkSVjaCC0uYvtYURlbG9S4X1klSt6oLVSXjNEnX2HyrNDiejncXeJPtBQP4QoNNvBY_9XiSjamklddBKiX_z9GX29J_G4fec2cXJ</recordid><startdate>20241221</startdate><enddate>20241221</enddate><creator>Pérez-Mingan, Gloria Caterine</creator><creator>Sierra-Merlano, Rita Magola</creator><creator>Yepes, Ismael</creator><creator>Vergara, María Judith Palomino</creator><creator>Ortiz, Miguel</creator><creator>Peña, Breiner</creator><creator>Cano-Pérez, Eder</creator><creator>Gómez-Camargo, Doris</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2443-6891</orcidid><orcidid>https://orcid.org/0000-0002-7243-4065</orcidid></search><sort><creationdate>20241221</creationdate><title>Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia</title><author>Pérez-Mingan, Gloria Caterine ; Sierra-Merlano, Rita Magola ; Yepes, Ismael ; Vergara, María Judith Palomino ; Ortiz, Miguel ; Peña, Breiner ; Cano-Pérez, Eder ; Gómez-Camargo, Doris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-3f3f6cde9ccf711fa974d7475c187e20f3cd83ed857c7e64a8a95a54104aaba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Blood</topic><topic>Body mass index</topic><topic>Colombia - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fatty liver</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Flow cytometry</topic><topic>Humans</topic><topic>Hypothesis testing</topic><topic>Informed consent</topic><topic>Insulin resistance</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukins</topic><topic>Leukocytes</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Peripheral blood</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatology</topic><topic>Risk factors</topic><topic>Steatosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Mingan, Gloria Caterine</creatorcontrib><creatorcontrib>Sierra-Merlano, Rita Magola</creatorcontrib><creatorcontrib>Yepes, Ismael</creatorcontrib><creatorcontrib>Vergara, María Judith Palomino</creatorcontrib><creatorcontrib>Ortiz, Miguel</creatorcontrib><creatorcontrib>Peña, Breiner</creatorcontrib><creatorcontrib>Cano-Pérez, Eder</creatorcontrib><creatorcontrib>Gómez-Camargo, Doris</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Biological Sciences</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Mingan, Gloria Caterine</au><au>Sierra-Merlano, Rita Magola</au><au>Yepes, Ismael</au><au>Vergara, María Judith Palomino</au><au>Ortiz, Miguel</au><au>Peña, Breiner</au><au>Cano-Pérez, Eder</au><au>Gómez-Camargo, Doris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2024-12-21</date><risdate>2024</risdate><volume>15</volume><issue>12</issue><spage>1639</spage><pages>1639-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>This study aimed to investigate the association of IL-6 with steatotic liver disease (SLD) and liver fibrosis (LF) in rheumatoid arthritis (RA) patients at a rheumatology center in Cartagena de Indias, Colombia.
This was a cross-sectional study that included RA and non-RA cases. The level of cellular expression of interleukin 6 (IL-6) was evaluated by flow cytometry in peripheral blood leukocytes, and the presence of SLD and LF was detected by elastosonography. The main outcome was to establish the association between the levels of cellular expression of IL-6 and the development of SLD and LF.
This study included 47 cases of RA and 34 cases on-RA, with a mean age of 54 and 55 years, respectively. The frequency of SLD was 55.3% in RA and 38.2% in non-RA. The frequency of LF was 12.8% in RA and 14.7% in non-RA, with no statistical difference. The levels of cellular expression of IL-6 were significantly higher in RA compared to non-RA. Cellular expression of IL-6 was associated with the presence of SLD (54% vs. 30.3%;
= 0.002). This association was not maintained in RA cases (49.5% vs. 47.6%;
= 0.571). No association was found between cellular expression of IL-6 and LF in the total population (43.8% vs. 42.7%;
= 0.813) nor in RA cases (59.41% vs. 48.3%;
= 0.526).
IL-6 levels were related to SLD in the evaluated sample, and RA was not a risk factor for SLD or LF. The prognostic role of IL-6 for SLD in patients with RA requires further studies.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39766906</pmid><doi>10.3390/genes15121639</doi><orcidid>https://orcid.org/0000-0002-2443-6891</orcidid><orcidid>https://orcid.org/0000-0002-7243-4065</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; PubMed (Medline); MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Arthritis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Blood Body mass index Colombia - epidemiology Cross-Sectional Studies Cytokines Ethylenediaminetetraacetic acid Fatty liver Fatty Liver - pathology Female Fibrosis Flow cytometry Humans Hypothesis testing Informed consent Insulin resistance Interleukin 6 Interleukin-6 - blood Interleukin-6 - genetics Interleukins Leukocytes Liver Liver cirrhosis Liver Cirrhosis - pathology Liver diseases Male Medical records Medical research Medicine, Experimental Metabolism Middle Aged Pathogenesis Peripheral blood Rheumatoid arthritis Rheumatoid factor Rheumatology Risk factors Steatosis |
| title | Relationship of Interleukin 6 with Hepatic Steatosis and Liver Fibrosis in Rheumatoid Arthritis at a Rheumatology Care Center in Cartagena, Colombia |
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