The 3′ region of bovine leukemia virus genome encodes a trans‐activator protein
The genome of bovine leukemia virus (BLV) contains several overlapping, long open reading frames 3′ to the envelope gene. Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans‐activator function capable of increasing the level of gene expression...
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| Veröffentlicht in: | The EMBO journal 1986-10, Vol.5 (10), p.2585-2589 |
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| container_end_page | 2589 |
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| container_title | The EMBO journal |
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| creator | Rosen, C.A. Sodroski, J.G. Willems, L. Kettmann, R. Campbell, K. Zaya, R. Burny, A. Haseltine, W.A. |
| description | The genome of bovine leukemia virus (BLV) contains several overlapping, long open reading frames 3′ to the envelope gene. Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans‐activator function capable of increasing the level of gene expression directed by the BLV long terminal repeat sequences. This study provides further evidence of the structural and functional similarities of the bovine leukemia virus and the human T lymphotropic viruses, HTLV‐I and HTLV‐II. |
| doi_str_mv | 10.1002/j.1460-2075.1986.tb04538.x |
| format | Article |
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Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans‐activator function capable of increasing the level of gene expression directed by the BLV long terminal repeat sequences. This study provides further evidence of the structural and functional similarities of the bovine leukemia virus and the human T lymphotropic viruses, HTLV‐I and HTLV‐II.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>bovine leukemia virus</subject><subject>Cell Line</subject><subject>DNA - metabolism</subject><subject>DNA Restriction Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genes, Viral</subject><subject>Humans</subject><subject>Leukemia Virus, Bovine - genetics</subject><subject>Life sciences</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Médecine vétérinaire & santé animale</subject><subject>Plasmids</subject><subject>Retroviridae - genetics</subject><subject>Retroviridae Proteins - genetics</subject><subject>Sciences du vivant</subject><subject>Transfection</subject><subject>Veterinary medicine & animal health</subject><issn>0261-4189</issn><issn>1460-2075</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhSMEKtPCIyBZCLGb4J_ETlgglarlR0UsKOsrx7lJPSTxYCeh3fUReBYeqU-C50cjWCFWvtI55_rYX5I8ZzRllPJXq5Rlki45VXnKykKmY0WzXBTpzYNkcZAeJgvKJVtmrCgfJ8chrCileaHYUXIkKBc0KxfJl6trJOL-7hfx2Fo3ENeQys12QNLh9A17q8ls_RRIi4PrkeBgXI2BaDJ6PYT7u5_ajHbWo_Nk7d2IdniSPGp0F_Dp_jxJvl6cX529X15-fvfh7PRyabJSFUuVN4KWrCk5q3IpCyOFqbkR0ui6ajKlUeWywVIwVWXKVDXmmOtKUV5T2ZhCnCRvdnvXU9VjbXCIlTpYe9trfwtOW_hbGew1tG4GxqRiuYwL-G5BZ7FFcL6yMPNtcDtPXQvaQIXAuSyA5YzTGHq5v9W77xOGEXobDHadHtBNAZRikpYi-6eRZbFCJBKNr3dG410IHpvDExiFDXBYwYYqbKjCBjjsgcNNDD_78xMO0T3hqL_Y6zoY3TURmrHhYFOFii4ebac72w_b4e1_FIDzT28_bmfxG91Gy68</recordid><startdate>198610</startdate><enddate>198610</enddate><creator>Rosen, C.A.</creator><creator>Sodroski, J.G.</creator><creator>Willems, L.</creator><creator>Kettmann, R.</creator><creator>Campbell, K.</creator><creator>Zaya, R.</creator><creator>Burny, A.</creator><creator>Haseltine, W.A.</creator><general>Nature Publishing Group</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope></search><sort><creationdate>198610</creationdate><title>The 3′ region of bovine leukemia virus genome encodes a trans‐activator protein</title><author>Rosen, C.A. ; Sodroski, J.G. ; Willems, L. ; Kettmann, R. ; Campbell, K. ; Zaya, R. ; Burny, A. ; Haseltine, W.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4978-75f3091f921b5668c63cd2c36cadbf47ae756fe9317b47cbde5e5ab702d06fc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>bovine leukemia virus</topic><topic>Cell Line</topic><topic>DNA - metabolism</topic><topic>DNA Restriction Enzymes</topic><topic>Fundamental and applied biological sciences. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences bovine leukemia virus Cell Line DNA - metabolism DNA Restriction Enzymes Fundamental and applied biological sciences. Psychology Gene expression Genes Genes, Viral Humans Leukemia Virus, Bovine - genetics Life sciences Molecular and cellular biology Molecular genetics Médecine vétérinaire & santé animale Plasmids Retroviridae - genetics Retroviridae Proteins - genetics Sciences du vivant Transfection Veterinary medicine & animal health |
| title | The 3′ region of bovine leukemia virus genome encodes a trans‐activator protein |
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