Structure and expression of cDNA and genes for human interferon‐beta‐2, a distinct species inducible by growth‐stimulatory cytokines

Induced human fibroblasts produce several mRNAs encoding interferon (IFN) activity. We previously cloned cDNA for a 1.3‐kb RNA designated IFN‐beta 2 and distinct from the 0.9‐kb IFN‐beta 1 mRNA. In vitro transcription‐‐translation mapping of the full‐length IFN‐beta 2 cDNA sequence, shows that it en...

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Veröffentlicht in:	The EMBO journal 1986-10, Vol.5 (10), p.2529-2537
Hauptverfasser:	Zilberstein, A., Ruggieri, R., Korn, J.H., Revel, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid sequence Animals beta -interferon Biological and medical sciences cDNA Cell Line cloning Cloning, Molecular Cricetinae cytokines DNA - analysis Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene Amplification Genes Genes. Genome Growth Substances - pharmacology Humans Interferon Type I - biosynthesis Interferon Type I - genetics man Mice Molecular and cellular biology Molecular genetics nucleotide sequence Plasmids Protein Biosynthesis restriction endonuclease mapping RNA, Messenger - genetics Simian virus 40 - genetics Tetrahydrofolate Dehydrogenase - genetics Transcription, Genetic Transfection
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