A Multi-Institutional Study on Ultrasound Image Analysis for Staging HBV-Derived Liver Fibrosis: A Potential Noninvasive Alternative to Liver Stiffness Measurement
Liver stiffness measurement is principal for staging liver fibrosis but not included in routine examinations. We investigated whether comparable diagnostic performance can be achieved by mining ultrasound images and developing a novel serum index (NSI). Texture features were extracted from ultrasoun...
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| Veröffentlicht in: | Clinical and translational gastroenterology 2024-12, Vol.15 (12), p.e00780 |
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| creator | Wang, Jincheng Cao, Lihua Liu, Fang Li, Chunhui Zhao, Peng Li, Zhaoyi Lu, Xiaojie Ye, Xiaohang Bao, Jianfeng |
| description | Liver stiffness measurement is principal for staging liver fibrosis but not included in routine examinations. We investigated whether comparable diagnostic performance can be achieved by mining ultrasound images and developing a novel serum index (NSI).
Texture features were extracted from ultrasound images. Spearman correlation and logistics regression selected independent variables for significant (F ≥ 2) and advanced (F ≥ 3) fibrosis. We compared the diagnostic performance of transient elastography (TE), ultrasound image biomarker, conventional serum indices (aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, gamma-glutamyl transpeptidase-to-platelet ratio), and NSI in 365 patients with chronic hepatitis B.
Among patients, 52.1% had significant fibrosis and 24.2% had advanced fibrosis. PLT, gamma-glutamyl transferase, prealbumin, and globulin were incorporated into NSI. In the validation group, TE achieved the best performance (area under the curve [AUC]: 0.765 [0.690-0.849] for significant fibrosis; 0.812 [0.745-0.878] for advanced fibrosis), followed by ultrasound image biomarker (AUC: 0.712 [0.629-0.795]; 0.678 [0.595-0.763]) and NSI (AUC: 0.630 [0.534-0.725]; 0.659 [0.572-0.745]), outperforming conventional indices.
Texture analysis enhances ultrasound's diagnostic utility, but TE remains superior. When TE is unavailable, ultrasound image analysis and NSI, incorporating prealbumin, can serve as alternative tools for fibrosis staging. |
| doi_str_mv | 10.14309/ctg.0000000000000780 |
| format | Article |
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Texture features were extracted from ultrasound images. Spearman correlation and logistics regression selected independent variables for significant (F ≥ 2) and advanced (F ≥ 3) fibrosis. We compared the diagnostic performance of transient elastography (TE), ultrasound image biomarker, conventional serum indices (aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, gamma-glutamyl transpeptidase-to-platelet ratio), and NSI in 365 patients with chronic hepatitis B.
Among patients, 52.1% had significant fibrosis and 24.2% had advanced fibrosis. PLT, gamma-glutamyl transferase, prealbumin, and globulin were incorporated into NSI. In the validation group, TE achieved the best performance (area under the curve [AUC]: 0.765 [0.690-0.849] for significant fibrosis; 0.812 [0.745-0.878] for advanced fibrosis), followed by ultrasound image biomarker (AUC: 0.712 [0.629-0.795]; 0.678 [0.595-0.763]) and NSI (AUC: 0.630 [0.534-0.725]; 0.659 [0.572-0.745]), outperforming conventional indices.
Texture analysis enhances ultrasound's diagnostic utility, but TE remains superior. When TE is unavailable, ultrasound image analysis and NSI, incorporating prealbumin, can serve as alternative tools for fibrosis staging.</description><identifier>ISSN: 2155-384X</identifier><identifier>EISSN: 2155-384X</identifier><identifier>DOI: 10.14309/ctg.0000000000000780</identifier><identifier>PMID: 39466667</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</publisher><subject>Adult ; Alcohol use ; Aspartate Aminotransferases - blood ; Biomarkers ; Biomarkers - blood ; Biopsy ; Body mass index ; Clinical medicine ; Correlation analysis ; Elasticity Imaging Techniques - methods ; Female ; gamma-Glutamyltransferase - blood ; Hepatitis B ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - diagnostic imaging ; Hepatitis B, Chronic - pathology ; Humans ; Infections ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - pathology ; Male ; Middle Aged ; Platelet Count ; Regression analysis ; ROC Curve ; Severity of Illness Index ; Software ; Ultrasonic imaging ; Variables ; Viruses</subject><ispartof>Clinical and translational gastroenterology, 2024-12, Vol.15 (12), p.e00780</ispartof><rights>Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.</rights><rights>2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1861-643f651f2309d0440299dd39ad2c5b29517be3b6e10d5b8fd5cb0acefeae30d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671071/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671071/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39466667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jincheng</creatorcontrib><creatorcontrib>Cao, Lihua</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Li, Chunhui</creatorcontrib><creatorcontrib>Zhao, Peng</creatorcontrib><creatorcontrib>Li, Zhaoyi</creatorcontrib><creatorcontrib>Lu, Xiaojie</creatorcontrib><creatorcontrib>Ye, Xiaohang</creatorcontrib><creatorcontrib>Bao, Jianfeng</creatorcontrib><title>A Multi-Institutional Study on Ultrasound Image Analysis for Staging HBV-Derived Liver Fibrosis: A Potential Noninvasive Alternative to Liver Stiffness Measurement</title><title>Clinical and translational gastroenterology</title><addtitle>Clin Transl Gastroenterol</addtitle><description>Liver stiffness measurement is principal for staging liver fibrosis but not included in routine examinations. We investigated whether comparable diagnostic performance can be achieved by mining ultrasound images and developing a novel serum index (NSI).
Texture features were extracted from ultrasound images. Spearman correlation and logistics regression selected independent variables for significant (F ≥ 2) and advanced (F ≥ 3) fibrosis. We compared the diagnostic performance of transient elastography (TE), ultrasound image biomarker, conventional serum indices (aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, gamma-glutamyl transpeptidase-to-platelet ratio), and NSI in 365 patients with chronic hepatitis B.
Among patients, 52.1% had significant fibrosis and 24.2% had advanced fibrosis. PLT, gamma-glutamyl transferase, prealbumin, and globulin were incorporated into NSI. In the validation group, TE achieved the best performance (area under the curve [AUC]: 0.765 [0.690-0.849] for significant fibrosis; 0.812 [0.745-0.878] for advanced fibrosis), followed by ultrasound image biomarker (AUC: 0.712 [0.629-0.795]; 0.678 [0.595-0.763]) and NSI (AUC: 0.630 [0.534-0.725]; 0.659 [0.572-0.745]), outperforming conventional indices.
Texture analysis enhances ultrasound's diagnostic utility, but TE remains superior. When TE is unavailable, ultrasound image analysis and NSI, incorporating prealbumin, can serve as alternative tools for fibrosis staging.</description><subject>Adult</subject><subject>Alcohol use</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biopsy</subject><subject>Body mass index</subject><subject>Clinical medicine</subject><subject>Correlation analysis</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Hepatitis B</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - diagnostic imaging</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Humans</subject><subject>Infections</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Count</subject><subject>Regression analysis</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Software</subject><subject>Ultrasonic imaging</subject><subject>Variables</subject><subject>Viruses</subject><issn>2155-384X</issn><issn>2155-384X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUk1P3DAQjapWBVF-QitLvfQSsON8uZcqUCgrLW0lStWb5cST1Cixqe2stL-HP9pZWNCCD_ZI894bz7xJkveMHrGcU3HcxeGI7p6qpq-S_YwVRcrr_M_rnXgvOQzhZgPKaVYL8TbZ4yIv8VT7yV1DLucxmnRhQzRxjsZZNZKrOOs1cZZcj9Gr4GaryWJSA5AG0-tgAumdR5gajB3Ixcnv9Ct4swJNlnh7cm5a7xD2mTTkp4tgo0HZ784au1IBIaQZI3ir4iaObku7iqbvLYRALkGF2cOEzHfJm16NAQ6370FyfX726_QiXf74tjhtlmnH6pKlZc77smB9hgPSNMdmhdCaC6WzrmgzUbCqBd6WwKgu2rrXRddS1UEPCjjVlB8kXx50b-d2At1haa9GeevNpPxaOmXk84w1f-XgVpKxsmK0Yqjwaavg3b8ZQpSTCR2Mo7Lg5iA5Q1fQgmxT7OML6I2bcR7jBpWLHA3NBaKKB1SH0wwe-qffMCrvV0HiKsiXq4C8D7utPLEejef_AdDpsvc</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Wang, Jincheng</creator><creator>Cao, Lihua</creator><creator>Liu, Fang</creator><creator>Li, Chunhui</creator><creator>Zhao, Peng</creator><creator>Li, Zhaoyi</creator><creator>Lu, Xiaojie</creator><creator>Ye, Xiaohang</creator><creator>Bao, Jianfeng</creator><general>Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</general><general>Wolters Kluwer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>A Multi-Institutional Study on Ultrasound Image Analysis for Staging HBV-Derived Liver Fibrosis: A Potential Noninvasive Alternative to Liver Stiffness Measurement</title><author>Wang, Jincheng ; 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We investigated whether comparable diagnostic performance can be achieved by mining ultrasound images and developing a novel serum index (NSI).
Texture features were extracted from ultrasound images. Spearman correlation and logistics regression selected independent variables for significant (F ≥ 2) and advanced (F ≥ 3) fibrosis. We compared the diagnostic performance of transient elastography (TE), ultrasound image biomarker, conventional serum indices (aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, gamma-glutamyl transpeptidase-to-platelet ratio), and NSI in 365 patients with chronic hepatitis B.
Among patients, 52.1% had significant fibrosis and 24.2% had advanced fibrosis. PLT, gamma-glutamyl transferase, prealbumin, and globulin were incorporated into NSI. In the validation group, TE achieved the best performance (area under the curve [AUC]: 0.765 [0.690-0.849] for significant fibrosis; 0.812 [0.745-0.878] for advanced fibrosis), followed by ultrasound image biomarker (AUC: 0.712 [0.629-0.795]; 0.678 [0.595-0.763]) and NSI (AUC: 0.630 [0.534-0.725]; 0.659 [0.572-0.745]), outperforming conventional indices.
Texture analysis enhances ultrasound's diagnostic utility, but TE remains superior. When TE is unavailable, ultrasound image analysis and NSI, incorporating prealbumin, can serve as alternative tools for fibrosis staging.</abstract><cop>United States</cop><pub>Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins</pub><pmid>39466667</pmid><doi>10.14309/ctg.0000000000000780</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alcohol use Aspartate Aminotransferases - blood Biomarkers Biomarkers - blood Biopsy Body mass index Clinical medicine Correlation analysis Elasticity Imaging Techniques - methods Female gamma-Glutamyltransferase - blood Hepatitis B Hepatitis B, Chronic - complications Hepatitis B, Chronic - diagnostic imaging Hepatitis B, Chronic - pathology Humans Infections Liver Liver - diagnostic imaging Liver - pathology Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology Male Middle Aged Platelet Count Regression analysis ROC Curve Severity of Illness Index Software Ultrasonic imaging Variables Viruses |
| title | A Multi-Institutional Study on Ultrasound Image Analysis for Staging HBV-Derived Liver Fibrosis: A Potential Noninvasive Alternative to Liver Stiffness Measurement |
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