Targeting protein modification: a new direction for immunotherapy of pancreatic cancer
Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processe...
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| Veröffentlicht in: | International journal of biological sciences 2025, Vol.21 (1), p.63-74 |
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| container_title | International journal of biological sciences |
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| creator | Ge, Xinyu Zhang, Ke Zhu, Jie Chen, Yuan Wang, Zhengwang Wang, Peng Xu, Peng Yao, Jie |
| description | Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research. |
| doi_str_mv | 10.7150/ijbs.101861 |
| format | Article |
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| identifier | ISSN: 1449-2288 |
| ispartof | International journal of biological sciences, 2025, Vol.21 (1), p.63-74 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Animals Humans Immunotherapy - methods Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - therapy Protein Processing, Post-Translational Review |
| title | Targeting protein modification: a new direction for immunotherapy of pancreatic cancer |
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