Functional group interactions of a 5-HT3R antagonist

Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT3R binding site. Site directed mutagenesis studies of the 5-HT3AR have revealed several amino acids that are thought to form part of the binding...

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Veröffentlicht in:	BMC biochemistry 2002-06, Vol.3 (1), p.16-16, Article 16
Hauptverfasser:	Venkataraman, Padmavati, Joshi, Prasad, Venkatachalan, Srinivasan P, Muthalagi, Mani, Parihar, Harish S, Kirschbaum, Karen S, Schulte, Marvin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - physiology Benzimidazoles - metabolism Benzyl Compounds - metabolism Cell Line Humans Kidney - cytology Kidney - embryology Mice Mutagenesis, Site-Directed - genetics Nitrogen - metabolism Patch-Clamp Techniques Piperazines - chemistry Piperazines - metabolism Piperidines - metabolism Protein Binding - physiology Protein Interaction Mapping - methods Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT3 Serotonin Antagonists - metabolism Structure-Activity Relationship Tryptophan - physiology Tyrosine - physiology
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