Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research

Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding...

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Veröffentlicht in:Alzheimer's & dementia 2024-12, Vol.20 (12), p.9014-9036
Hauptverfasser: Nuytemans, Karen, Franzen, Sanne, Broce, Iris J., Caramelli, Paulo, Ellajosyula, Ratnavalli, Finger, Elizabeth, Gupta, Veer, Gupta, Vivek, Illán‐Gala, Ignacio, Loi, Samantha M., Morhardt, Darby, Pijnenburg, Yolande, Rascovsky, Katya, Williams, Monique M., Yokoyama, Jennifer S., Acosta‐Uribe, Juliana, Akinyemi, Rufus, Alladi, Suvarna, Ayele, Biniyam A., Ayhan, Yavuz, Bourdage, Renelle, Castro‐Suarez, Sheila, Souza, Leonardo Cruz, Dacks, Penny, Boer, Sterre C. M., Leon, Jessica, Dodge, Shana, Grasso, Stephanie, Ghoshal, Nupur, Kamath, Vidyulata, Kumfor, Fiona, Matias‐Guiu, Jordi A., Narme, Pauline, Nielsen, T. Rune, Okhuevbie, Daniel, Piña‐Escudero, Stefanie, Ruiz‐Garcia, Ramiro, Ryan, Brigid, Scarioni, Marta, Slachevsky, Andrea, Suarez‐Gonzalez, Aida, Tee, Boon Lead, Tsoy, Elena, Ulugut, Hulya, Onyike, Chiadi U., Babulal, Ganesh M.
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container_end_page 9036
container_issue 12
container_start_page 9014
container_title Alzheimer's & dementia
container_volume 20
creator Nuytemans, Karen
Franzen, Sanne
Broce, Iris J.
Caramelli, Paulo
Ellajosyula, Ratnavalli
Finger, Elizabeth
Gupta, Veer
Gupta, Vivek
Illán‐Gala, Ignacio
Loi, Samantha M.
Morhardt, Darby
Pijnenburg, Yolande
Rascovsky, Katya
Williams, Monique M.
Yokoyama, Jennifer S.
Acosta‐Uribe, Juliana
Akinyemi, Rufus
Alladi, Suvarna
Ayele, Biniyam A.
Ayhan, Yavuz
Bourdage, Renelle
Castro‐Suarez, Sheila
Souza, Leonardo Cruz
Dacks, Penny
Boer, Sterre C. M.
Leon, Jessica
Dodge, Shana
Grasso, Stephanie
Ghoshal, Nupur
Kamath, Vidyulata
Kumfor, Fiona
Matias‐Guiu, Jordi A.
Narme, Pauline
Nielsen, T. Rune
Okhuevbie, Daniel
Piña‐Escudero, Stefanie
Ruiz‐Garcia, Ramiro
Ryan, Brigid
Scarioni, Marta
Slachevsky, Andrea
Suarez‐Gonzalez, Aida
Tee, Boon Lead
Tsoy, Elena
Ulugut, Hulya
Onyike, Chiadi U.
Babulal, Ganesh M.
description Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
doi_str_mv 10.1002/alz.14312
format Article
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Rune</creatorcontrib><creatorcontrib>Okhuevbie, Daniel</creatorcontrib><creatorcontrib>Piña‐Escudero, Stefanie</creatorcontrib><creatorcontrib>Ruiz‐Garcia, Ramiro</creatorcontrib><creatorcontrib>Ryan, Brigid</creatorcontrib><creatorcontrib>Scarioni, Marta</creatorcontrib><creatorcontrib>Slachevsky, Andrea</creatorcontrib><creatorcontrib>Suarez‐Gonzalez, Aida</creatorcontrib><creatorcontrib>Tee, Boon Lead</creatorcontrib><creatorcontrib>Tsoy, Elena</creatorcontrib><creatorcontrib>Ulugut, Hulya</creatorcontrib><creatorcontrib>Onyike, Chiadi U.</creatorcontrib><creatorcontrib>Babulal, Ganesh M.</creatorcontrib><creatorcontrib>ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA</creatorcontrib><creatorcontrib>ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's &amp; dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nuytemans, Karen</au><au>Franzen, Sanne</au><au>Broce, Iris J.</au><au>Caramelli, Paulo</au><au>Ellajosyula, Ratnavalli</au><au>Finger, Elizabeth</au><au>Gupta, Veer</au><au>Gupta, Vivek</au><au>Illán‐Gala, Ignacio</au><au>Loi, Samantha M.</au><au>Morhardt, Darby</au><au>Pijnenburg, Yolande</au><au>Rascovsky, Katya</au><au>Williams, Monique M.</au><au>Yokoyama, Jennifer S.</au><au>Acosta‐Uribe, Juliana</au><au>Akinyemi, Rufus</au><au>Alladi, Suvarna</au><au>Ayele, Biniyam A.</au><au>Ayhan, Yavuz</au><au>Bourdage, Renelle</au><au>Castro‐Suarez, Sheila</au><au>Souza, Leonardo Cruz</au><au>Dacks, Penny</au><au>Boer, Sterre C. M.</au><au>Leon, Jessica</au><au>Dodge, Shana</au><au>Grasso, Stephanie</au><au>Ghoshal, Nupur</au><au>Kamath, Vidyulata</au><au>Kumfor, Fiona</au><au>Matias‐Guiu, Jordi A.</au><au>Narme, Pauline</au><au>Nielsen, T. Rune</au><au>Okhuevbie, Daniel</au><au>Piña‐Escudero, Stefanie</au><au>Ruiz‐Garcia, Ramiro</au><au>Ryan, Brigid</au><au>Scarioni, Marta</au><au>Slachevsky, Andrea</au><au>Suarez‐Gonzalez, Aida</au><au>Tee, Boon Lead</au><au>Tsoy, Elena</au><au>Ulugut, Hulya</au><au>Onyike, Chiadi U.</au><au>Babulal, Ganesh M.</au><aucorp>ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA</aucorp><aucorp>ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research</atitle><jtitle>Alzheimer's &amp; dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2024-12</date><risdate>2024</risdate><volume>20</volume><issue>12</issue><spage>9014</spage><epage>9036</epage><pages>9014-9036</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>39535468</pmid><doi>10.1002/alz.14312</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0003-2670-4914</orcidid><oa>free_for_read</oa></addata></record>
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1552-5279
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source MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; Wiley Online Library All Journals; PubMed Central
subjects biomarkers
Biomedical Research
Cultural Diversity
epidemiology
ethnicity
frontotemporal dementia
Frontotemporal Dementia - diagnosis
Frontotemporal Dementia - genetics
Frontotemporal Dementia - therapy
genetics
Healthcare Disparities
Humans
infrastructure
title Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
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