Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding...
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creator | Nuytemans, Karen Franzen, Sanne Broce, Iris J. Caramelli, Paulo Ellajosyula, Ratnavalli Finger, Elizabeth Gupta, Veer Gupta, Vivek Illán‐Gala, Ignacio Loi, Samantha M. Morhardt, Darby Pijnenburg, Yolande Rascovsky, Katya Williams, Monique M. Yokoyama, Jennifer S. Acosta‐Uribe, Juliana Akinyemi, Rufus Alladi, Suvarna Ayele, Biniyam A. Ayhan, Yavuz Bourdage, Renelle Castro‐Suarez, Sheila Souza, Leonardo Cruz Dacks, Penny Boer, Sterre C. M. Leon, Jessica Dodge, Shana Grasso, Stephanie Ghoshal, Nupur Kamath, Vidyulata Kumfor, Fiona Matias‐Guiu, Jordi A. Narme, Pauline Nielsen, T. Rune Okhuevbie, Daniel Piña‐Escudero, Stefanie Ruiz‐Garcia, Ramiro Ryan, Brigid Scarioni, Marta Slachevsky, Andrea Suarez‐Gonzalez, Aida Tee, Boon Lead Tsoy, Elena Ulugut, Hulya Onyike, Chiadi U. Babulal, Ganesh M. |
description | Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research. |
doi_str_mv | 10.1002/alz.14312 |
format | Article |
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M. ; Leon, Jessica ; Dodge, Shana ; Grasso, Stephanie ; Ghoshal, Nupur ; Kamath, Vidyulata ; Kumfor, Fiona ; Matias‐Guiu, Jordi A. ; Narme, Pauline ; Nielsen, T. Rune ; Okhuevbie, Daniel ; Piña‐Escudero, Stefanie ; Ruiz‐Garcia, Ramiro ; Ryan, Brigid ; Scarioni, Marta ; Slachevsky, Andrea ; Suarez‐Gonzalez, Aida ; Tee, Boon Lead ; Tsoy, Elena ; Ulugut, Hulya ; Onyike, Chiadi U. ; Babulal, Ganesh M.</creator><creatorcontrib>Nuytemans, Karen ; Franzen, Sanne ; Broce, Iris J. ; Caramelli, Paulo ; Ellajosyula, Ratnavalli ; Finger, Elizabeth ; Gupta, Veer ; Gupta, Vivek ; Illán‐Gala, Ignacio ; Loi, Samantha M. ; Morhardt, Darby ; Pijnenburg, Yolande ; Rascovsky, Katya ; Williams, Monique M. ; Yokoyama, Jennifer S. ; Acosta‐Uribe, Juliana ; Akinyemi, Rufus ; Alladi, Suvarna ; Ayele, Biniyam A. ; Ayhan, Yavuz ; Bourdage, Renelle ; Castro‐Suarez, Sheila ; Souza, Leonardo Cruz ; Dacks, Penny ; Boer, Sterre C. M. ; Leon, Jessica ; Dodge, Shana ; Grasso, Stephanie ; Ghoshal, Nupur ; Kamath, Vidyulata ; Kumfor, Fiona ; Matias‐Guiu, Jordi A. ; Narme, Pauline ; Nielsen, T. Rune ; Okhuevbie, Daniel ; Piña‐Escudero, Stefanie ; Ruiz‐Garcia, Ramiro ; Ryan, Brigid ; Scarioni, Marta ; Slachevsky, Andrea ; Suarez‐Gonzalez, Aida ; Tee, Boon Lead ; Tsoy, Elena ; Ulugut, Hulya ; Onyike, Chiadi U. ; Babulal, Ganesh M. ; ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA ; ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA</creatorcontrib><description>Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). 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language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11667558 |
source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; Wiley Online Library All Journals; PubMed Central |
subjects | biomarkers Biomedical Research Cultural Diversity epidemiology ethnicity frontotemporal dementia Frontotemporal Dementia - diagnosis Frontotemporal Dementia - genetics Frontotemporal Dementia - therapy genetics Healthcare Disparities Humans infrastructure |
title | Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T13%3A00%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gaps%20in%20biomedical%20research%20in%20frontotemporal%20dementia:%20A%20call%20for%20diversity%20and%20disparities%20focused%20research&rft.jtitle=Alzheimer's%20&%20dementia&rft.au=Nuytemans,%20Karen&rft.aucorp=ISTAART%20Frontotemporal%20Dementia%20and%20Related%20Disorders%20PIA,%20ISTAART%20Diversity%20and%20Disparities%20PIA&rft.date=2024-12&rft.volume=20&rft.issue=12&rft.spage=9014&rft.epage=9036&rft.pages=9014-9036&rft.issn=1552-5260&rft.eissn=1552-5279&rft_id=info:doi/10.1002/alz.14312&rft_dat=%3Cproquest_pubme%3E3128816694%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3128816694&rft_id=info:pmid/39535468&rfr_iscdi=true |