Associations between AHA's Life's Essential 8 and cognition in midlife and older adults
INTRODUCTION This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults. METHODS Participants (N = 1539) were from the Healthy Agi...
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| Veröffentlicht in: | Alzheimer's & dementia 2024-12, Vol.20 (12), p.8566-8575 |
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| creator | Master, Lindsay Shen, Yuqi Allan, Alexa C. Beydoun, May A. Zonderman, Alan B. Evans, Michele K. Buxton, Orfeu M. Gamaldo, Alyssa A. |
| description | INTRODUCTION
This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults.
METHODS
Participants (N = 1539) were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Cross‐sectional multivariable regression examined the associations between LE8 and cognition. Secondary analyses compared model performance between LE8 and LS7 measures on cognition from the same available sample.
RESULTS
Higher LE8 scores were associated with better global cognitive performance, working memory, and attention. The LS7 model outperformed the LE8 model on global cognitive performance, but the LE8 model outperformed the LS7 model for the working memory domain.
DISCUSSION
Better cardiovascular health (CVH) was associated with better cognitive performance among US middle‐aged and older adults. However, the association between CVH and specific cognitive domains varies when using LE8 versus LS7.
Highlights
Cardiovascular health (CVH) is associated with cognitive performance.
Life's Essential 8 (LE8) is a new construct to quantify CVH.
Associations between LE8 and cognition were assessed.
Higher LE8 was associated with better global cognitive performance.
Higher LE8 was also associated with better working memory and attention. |
| doi_str_mv | 10.1002/alz.14294 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11667537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120058259</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3064-aab2e96d343f262fb43c664affa232e6f4a9c6bf091afb05b7c5630ad11d2ee73</originalsourceid><addsrcrecordid>eNp1kctKAzEUhoMo3he-gGSnLqq5t7OSoXiDghtFcBPOZE40kk50MlX06Z1aLbpwdQLn48vP-QnZ4-yYMyZOIH4ccyUKtUI2udZioMWwWF2-DdsgWzk_MabYiOt1siELpZSQYpPclTknF6ALqcm0wu4NsaHlZXmQ6SR47MdZzth0ASIdUWhq6tJDE-Y8DQ2dhjr22NcixRpbCvUsdnmHrHmIGXe_5za5PT-7GV8OJtcXV-NyMnCSGTUAqAQWppZKemGEr5R0xijwHvp4aLyCwpnKs4KDr5iuhk4byaDmvBaIQ7lNThfe51k1xdr1SVuI9rkNU2jfbYJg_26a8Ggf0qvl3JihlnPD4behTS8zzJ2dhuwwRmgwzbKVXDCmR0IXPXq0QF2bcm7RL__hzM6bsH0T9quJnt3_HWxJ_py-B04WwFuI-P6_yZaT-4XyE647k5Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3120058259</pqid></control><display><type>article</type><title>Associations between AHA's Life's Essential 8 and cognition in midlife and older adults</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>Wiley Online Library Journals Frontfile Complete</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Master, Lindsay ; Shen, Yuqi ; Allan, Alexa C. ; Beydoun, May A. ; Zonderman, Alan B. ; Evans, Michele K. ; Buxton, Orfeu M. ; Gamaldo, Alyssa A.</creator><creatorcontrib>Master, Lindsay ; Shen, Yuqi ; Allan, Alexa C. ; Beydoun, May A. ; Zonderman, Alan B. ; Evans, Michele K. ; Buxton, Orfeu M. ; Gamaldo, Alyssa A.</creatorcontrib><description>INTRODUCTION
This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults.
METHODS
Participants (N = 1539) were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Cross‐sectional multivariable regression examined the associations between LE8 and cognition. Secondary analyses compared model performance between LE8 and LS7 measures on cognition from the same available sample.
RESULTS
Higher LE8 scores were associated with better global cognitive performance, working memory, and attention. The LS7 model outperformed the LE8 model on global cognitive performance, but the LE8 model outperformed the LS7 model for the working memory domain.
DISCUSSION
Better cardiovascular health (CVH) was associated with better cognitive performance among US middle‐aged and older adults. However, the association between CVH and specific cognitive domains varies when using LE8 versus LS7.
Highlights
Cardiovascular health (CVH) is associated with cognitive performance.
Life's Essential 8 (LE8) is a new construct to quantify CVH.
Associations between LE8 and cognition were assessed.
Higher LE8 was associated with better global cognitive performance.
Higher LE8 was also associated with better working memory and attention.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.14294</identifier><identifier>PMID: 39444232</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Aged ; aging ; Aging - physiology ; Aging - psychology ; Attention - physiology ; cardiovascular disease ; cognition ; Cognition - physiology ; Cross-Sectional Studies ; Female ; Healthy Aging - physiology ; Healthy Aging - psychology ; Humans ; Life's Essential 8 ; Male ; Memory, Short-Term - physiology ; Middle Aged ; Neuropsychological Tests - statistics & numerical data ; sleep</subject><ispartof>Alzheimer's & dementia, 2024-12, Vol.20 (12), p.8566-8575</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.</rights><rights>2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3064-aab2e96d343f262fb43c664affa232e6f4a9c6bf091afb05b7c5630ad11d2ee73</cites><orcidid>0000-0001-5057-633X ; 0000-0002-6523-4778 ; 0009-0004-3047-2209 ; 0000-0003-3672-5938 ; 0009-0000-7548-5100 ; 0000-0002-6577-5398</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667537/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667537/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39444232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Master, Lindsay</creatorcontrib><creatorcontrib>Shen, Yuqi</creatorcontrib><creatorcontrib>Allan, Alexa C.</creatorcontrib><creatorcontrib>Beydoun, May A.</creatorcontrib><creatorcontrib>Zonderman, Alan B.</creatorcontrib><creatorcontrib>Evans, Michele K.</creatorcontrib><creatorcontrib>Buxton, Orfeu M.</creatorcontrib><creatorcontrib>Gamaldo, Alyssa A.</creatorcontrib><title>Associations between AHA's Life's Essential 8 and cognition in midlife and older adults</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>INTRODUCTION
This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults.
METHODS
Participants (N = 1539) were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Cross‐sectional multivariable regression examined the associations between LE8 and cognition. Secondary analyses compared model performance between LE8 and LS7 measures on cognition from the same available sample.
RESULTS
Higher LE8 scores were associated with better global cognitive performance, working memory, and attention. The LS7 model outperformed the LE8 model on global cognitive performance, but the LE8 model outperformed the LS7 model for the working memory domain.
DISCUSSION
Better cardiovascular health (CVH) was associated with better cognitive performance among US middle‐aged and older adults. However, the association between CVH and specific cognitive domains varies when using LE8 versus LS7.
Highlights
Cardiovascular health (CVH) is associated with cognitive performance.
Life's Essential 8 (LE8) is a new construct to quantify CVH.
Associations between LE8 and cognition were assessed.
Higher LE8 was associated with better global cognitive performance.
Higher LE8 was also associated with better working memory and attention.</description><subject>Aged</subject><subject>aging</subject><subject>Aging - physiology</subject><subject>Aging - psychology</subject><subject>Attention - physiology</subject><subject>cardiovascular disease</subject><subject>cognition</subject><subject>Cognition - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Healthy Aging - physiology</subject><subject>Healthy Aging - psychology</subject><subject>Humans</subject><subject>Life's Essential 8</subject><subject>Male</subject><subject>Memory, Short-Term - physiology</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>sleep</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMo3he-gGSnLqq5t7OSoXiDghtFcBPOZE40kk50MlX06Z1aLbpwdQLn48vP-QnZ4-yYMyZOIH4ccyUKtUI2udZioMWwWF2-DdsgWzk_MabYiOt1siELpZSQYpPclTknF6ALqcm0wu4NsaHlZXmQ6SR47MdZzth0ASIdUWhq6tJDE-Y8DQ2dhjr22NcixRpbCvUsdnmHrHmIGXe_5za5PT-7GV8OJtcXV-NyMnCSGTUAqAQWppZKemGEr5R0xijwHvp4aLyCwpnKs4KDr5iuhk4byaDmvBaIQ7lNThfe51k1xdr1SVuI9rkNU2jfbYJg_26a8Ggf0qvl3JihlnPD4behTS8zzJ2dhuwwRmgwzbKVXDCmR0IXPXq0QF2bcm7RL__hzM6bsH0T9quJnt3_HWxJ_py-B04WwFuI-P6_yZaT-4XyE647k5Y</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Master, Lindsay</creator><creator>Shen, Yuqi</creator><creator>Allan, Alexa C.</creator><creator>Beydoun, May A.</creator><creator>Zonderman, Alan B.</creator><creator>Evans, Michele K.</creator><creator>Buxton, Orfeu M.</creator><creator>Gamaldo, Alyssa A.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5057-633X</orcidid><orcidid>https://orcid.org/0000-0002-6523-4778</orcidid><orcidid>https://orcid.org/0009-0004-3047-2209</orcidid><orcidid>https://orcid.org/0000-0003-3672-5938</orcidid><orcidid>https://orcid.org/0009-0000-7548-5100</orcidid><orcidid>https://orcid.org/0000-0002-6577-5398</orcidid></search><sort><creationdate>202412</creationdate><title>Associations between AHA's Life's Essential 8 and cognition in midlife and older adults</title><author>Master, Lindsay ; Shen, Yuqi ; Allan, Alexa C. ; Beydoun, May A. ; Zonderman, Alan B. ; Evans, Michele K. ; Buxton, Orfeu M. ; Gamaldo, Alyssa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3064-aab2e96d343f262fb43c664affa232e6f4a9c6bf091afb05b7c5630ad11d2ee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>aging</topic><topic>Aging - physiology</topic><topic>Aging - psychology</topic><topic>Attention - physiology</topic><topic>cardiovascular disease</topic><topic>cognition</topic><topic>Cognition - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Healthy Aging - physiology</topic><topic>Healthy Aging - psychology</topic><topic>Humans</topic><topic>Life's Essential 8</topic><topic>Male</topic><topic>Memory, Short-Term - physiology</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Master, Lindsay</creatorcontrib><creatorcontrib>Shen, Yuqi</creatorcontrib><creatorcontrib>Allan, Alexa C.</creatorcontrib><creatorcontrib>Beydoun, May A.</creatorcontrib><creatorcontrib>Zonderman, Alan B.</creatorcontrib><creatorcontrib>Evans, Michele K.</creatorcontrib><creatorcontrib>Buxton, Orfeu M.</creatorcontrib><creatorcontrib>Gamaldo, Alyssa A.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Master, Lindsay</au><au>Shen, Yuqi</au><au>Allan, Alexa C.</au><au>Beydoun, May A.</au><au>Zonderman, Alan B.</au><au>Evans, Michele K.</au><au>Buxton, Orfeu M.</au><au>Gamaldo, Alyssa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between AHA's Life's Essential 8 and cognition in midlife and older adults</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2024-12</date><risdate>2024</risdate><volume>20</volume><issue>12</issue><spage>8566</spage><epage>8575</epage><pages>8566-8575</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>INTRODUCTION
This study evaluated the associations between Life's Essential 8 (LE8) and cognitive performance, and compared the strength of the relationships of Life's Simple 7 (LS7) and LE8 to cognition in midlife and older adults.
METHODS
Participants (N = 1539) were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Cross‐sectional multivariable regression examined the associations between LE8 and cognition. Secondary analyses compared model performance between LE8 and LS7 measures on cognition from the same available sample.
RESULTS
Higher LE8 scores were associated with better global cognitive performance, working memory, and attention. The LS7 model outperformed the LE8 model on global cognitive performance, but the LE8 model outperformed the LS7 model for the working memory domain.
DISCUSSION
Better cardiovascular health (CVH) was associated with better cognitive performance among US middle‐aged and older adults. However, the association between CVH and specific cognitive domains varies when using LE8 versus LS7.
Highlights
Cardiovascular health (CVH) is associated with cognitive performance.
Life's Essential 8 (LE8) is a new construct to quantify CVH.
Associations between LE8 and cognition were assessed.
Higher LE8 was associated with better global cognitive performance.
Higher LE8 was also associated with better working memory and attention.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>39444232</pmid><doi>10.1002/alz.14294</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5057-633X</orcidid><orcidid>https://orcid.org/0000-0002-6523-4778</orcidid><orcidid>https://orcid.org/0009-0004-3047-2209</orcidid><orcidid>https://orcid.org/0000-0003-3672-5938</orcidid><orcidid>https://orcid.org/0009-0000-7548-5100</orcidid><orcidid>https://orcid.org/0000-0002-6577-5398</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; PubMed Central; PubMed Central Open Access |
| subjects | Aged aging Aging - physiology Aging - psychology Attention - physiology cardiovascular disease cognition Cognition - physiology Cross-Sectional Studies Female Healthy Aging - physiology Healthy Aging - psychology Humans Life's Essential 8 Male Memory, Short-Term - physiology Middle Aged Neuropsychological Tests - statistics & numerical data sleep |
| title | Associations between AHA's Life's Essential 8 and cognition in midlife and older adults |
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