Integrating oxygen-boosted sonodynamic therapy and ferroptosis via engineered exosomes for effective cancer treatment

Ferroptosis and sonodynamic therapy (SDT) are both promising therapeutic modalities, but their clinical application remains challenging due to the hypoxic tumor microenvironment and limited supply of polyunsaturated fatty acids. Developing an agent with oxygen-enhanced SDT and increased ferroptosis...

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Veröffentlicht in:	Theranostics 2025, Vol.15 (1), p.68-85
Hauptverfasser:	Wu, Mingbo, Zhang, Zhanlin, Li, Dong, Ruan, Xiaomiao, Yang, Jingwen, Chen, Siyi, Li, Xin, Ling, Wenwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - therapy Catalase - metabolism Cell Line, Tumor Coenzyme A Ligases - metabolism Exosomes - metabolism Female Ferroptosis - drug effects Humans Mice Mice, Inbred BALB C Oxygen - metabolism Reactive Oxygen Species - metabolism Research Paper Tumor Microenvironment - drug effects Ultrasonic Therapy - methods
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