Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases

Highly reactive metabolic intermediates and other small molecules frequently react with amino acid side chains, leading to non-enzymatic posttranslational modifications (nPTMs) of proteins. The abundance of these modifications increases under high metabolic activity or stress conditions and can dram...

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Veröffentlicht in:RSC chemical biology 2024-12
Hauptverfasser: Baldensperger, Tim, Preissler, Miriam, Becker, Christian F W
Format: Artikel
Sprache:eng
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