Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis

Aneuploidy in eggs is a leading cause of miscarriages or viable developmental syndromes. Aneuploidy rates differ between individual chromosomes. For instance, chromosome 21 frequently missegregates, resulting in Down Syndrome. What causes chromosome-specific aneuploidy in meiosis is unclear. Chromos...

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Veröffentlicht in:	Nature communications 2024-12, Vol.15 (1), p.10713-20
Hauptverfasser:	Bellou, Eirini, Zielinska, Agata P., Mönnich, Eike Urs, Schweizer, Nina, Politi, Antonio Z., Wellecke, Antonina, Sibold, Claus, Tandler-Schneider, Andreas, Schuh, Melina
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14 14/19 14/63 631/136/2434 631/80/103 631/80/641/1633 Aneuploidy Animals Bias Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell division Centromere - genetics Centromere - metabolism Centromeres Chromatids Chromatids - genetics Chromatids - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome 21 Chromosome Segregation Chromosomes Cohesin Cohesins Cohesion Down's syndrome Eggs Female Gametocytes Humanities and Social Sciences Humans Kinetochores Kinetochores - metabolism Mammals Meiosis Meiosis - genetics multidisciplinary Oocytes Oocytes - metabolism Science Science (multidisciplinary) Sister chromatids Spindle Apparatus - metabolism Swine
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