The KCa3.1 Channel Blocker TRAM-34 and Minocycline Prevent Fructose-Induced Hypertension in Rats

Abstract BACKGROUND High fructose consumption increases blood pressure through microglia-related neuroinflammation in rats. Since intermediate-conductance calcium-activated potassium channels (KCa3.1) potentiates microglial reactivity, we examined whether the pretreatment with the KCa3.1 channel blo...

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Veröffentlicht in:	American journal of hypertension 2024-11, Vol.37 (12), p.995-1002
Hauptverfasser:	Hamad, Abdelrahman, Ozkan, Melike Hacer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Cytokines - blood Cytokines - metabolism Disease Models, Animal Fructose Hypertension - chemically induced Hypertension - physiopathology Hypertension - prevention & control Inflammation Mediators - blood Inflammation Mediators - metabolism Insulin - blood Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric Arteries - physiopathology Microglia - drug effects Microglia - metabolism Minocycline - pharmacology Original Contributions Potassium Channel Blockers - pharmacology Pyrazoles - pharmacology Rats Rats, Wistar Vasodilation - drug effects
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