Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation

Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to c...

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Veröffentlicht in:EBioMedicine 2024-12, Vol.110, p.105411, Article 105411
Hauptverfasser: An, Andy Y., Acton, Erica, Idoko, Olubukola T., Shannon, Casey P., Blimkie, Travis M., Falsafi, Reza, Wariri, Oghenebrume, Dibbasey, Tida, Bennike, Tue Bjerg, Smolen, Kinga K., Diray-Arce, Joann, Ben-Othman, Rym, Angelidou, Asimenia, Odumade, Oludare A., Martino, David, Tebbutt, Scott J., Levy, Ofer, Steen, Hanno, Kollmann, Tobias R., Kampmann, Beate, Hancock, Robert E.W., Lee, Amy H., Amenyogbe, Nelly, Bao, Winnie, Bennike, Tue, Blimkie, Travis, Brinkman, Ryan R., Brook, Byron, Cai, Bing, Checkervarty, Abhinav, Chen, Jing, Chen, Virginia, Cooney, Mitchell, Darboe, Alansana, Dhillon, Bhavjinder K., Fatou, Benoit, Ford, Rebecca, Golding, Christian N., Harbeson, Danny J., He, Daniel, Hinshaw, Samuel H., Hoch, Annmarie, Huang, Joe, Imam, Abdulazeez, Kirarock, Wendy, Karoly, Meagan E., Kraft, Ken, Larsen, Kristina, Lasky-Su, Jessica, Liu, Aaron, Liu, Mark, M, Marchant, Arnaud, Masiria, Geraldine, Martino, David Jim, Matlam, John Paul, McEnaney, Kerry, McLoughlin, Caitlyn, Montante, Sebastiano, Ndure, Jorjoh, Nguyen, Athena, Njie-Jobe, Jainaba, Ozonoff, Al, Pak, Jensen, Palma, Paolo, Parker, Edward P.K., Pettengill, Matthew A., Plotkin, Alec, Pomat, William S., Rao, Shun, Richmond, Peter C., Roberts, Elishia, Saleu, Gerard, Sanca, Lilica, Sanchez-Schmitz, Guzman, Schaltz-Buchholzer, Frederik, Singh, Amrit, Smith, Maren, Strandmark, Julia, van den Biggelaar, Anita H.J., van Haren, Simon D., Varankovich, Natallia, Vignolo, Sofia, Vo, Diana
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