SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression

Synovial sarcoma (SS) is a rare soft tissue sarcoma characterized by high-grade malignancy and poor prognosis. Preliminary research indicates that apoptosis evasion is a key factor in SS progression, primarily attributed to the overexpression of anti-apoptotic genes. However, the mechanisms underlyi...

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Veröffentlicht in:	Cell biology and toxicology 2024-12, Vol.41 (1), p.8, Article 8
Hauptverfasser:	Qin, Wenjing, Peng, Changliang, Yang, Xianhe, Jiang, Alan, Zhong, Nanshan, Liu, Yunyun, Zhang, Xiaochun, Hirbe, Angela C., Ma, Mei, Yue, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-2 protein Biochemistry Biomedical and Life Sciences Cell Biology Cell Line, Tumor Disease Progression Female Fusion protein Gene Expression Regulation, Neoplastic Gene regulation Humans In vivo methods and tests Kinases Life Sciences Male Malignancy Mice Mice, Inbred BALB C Mice, Nude Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pharmacology/Toxicology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Sarcoma Sarcoma, Synovial - genetics Sarcoma, Synovial - metabolism Sarcoma, Synovial - pathology Signal Transduction Soft tissue sarcoma Soft tissues Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Synovial sarcoma TYK2 Kinase - genetics TYK2 Kinase - metabolism Tyk2 protein Tyrosine
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