High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience

Pituitary neuroendocrine tumors (PitNET) that metastasize comprise ~ 0.2% of adenohypophyseal tumors are aggressive and are challenging to treat. However, many non-metastatic tumors are also aggressive. Herein, we review 21 specimens from 13 patients at UCSF with metastatic PitNETs (CSF or systemic,...

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Veröffentlicht in:	Endocrine pathology 2024-12, Vol.35 (4), p.338-348
Hauptverfasser:	Terry, Merryl, Nguyen, Minh P., Tang, Vivian, Guney, Ekin, Bharani, Krishna L., Dahiya, Sonika, Choutka, Ondrej, Borys, Ewa, Reis, Gerald, Blevins, Lewis, Aghi, Manish K., Kunwar, Sandeep, DeGroot, John, Raleigh, David R., Pekmezci, Melike, Bollen, Andrew W., Cha, Soonmee, Joseph, Nancy M., Perry, Arie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aneuploidy Cell Transformation, Neoplastic - pathology Cerebrospinal fluid Disease Progression Endocrinology Female Gene deletion Genetic transformation Humans Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Grading Neoplasm Metastasis - pathology Neuroendocrine tumors Neuroendocrine Tumors - pathology Null cells Oncology p53 Protein Pathology Pituitary Pituitary (anterior) Pituitary Neoplasms - genetics Pituitary Neoplasms - pathology PTEN protein Sarcoma - genetics Sarcoma - pathology Tumors Young Adult
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