CUL4B protects kidneys from acute injury by restraining p53/PAI-1 signaling

Acute kidney injury (AKI) caused by nephrotoxins, ischemia reperfusion (IR) or sepsis is associated with high morbidity and mortality. Unveiling new mechanisms underlying AKI can help develop new therapeutic strategy. Cullin 4B (CUL4B) is a scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2024-12, Vol.15 (12), p.915-12, Article 915
Hauptverfasser:	Liu, Kaixuan, Hao, Xiaoyu, Gao, Yangfan, Cao, Zhiyuan, Hou, Min, Qin, Lining, Song, Yu, Wang, Molin, Jiang, Baichun, Liu, Qiao, Zou, Yongxin, Gong, Yaoqin, Liu, Guangyi, Sun, Gongping
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/2 13/31 13/51 38 38/109 38/91 631/80/82 692/699/1585/4 82 Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Antibodies Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Culture Cell death Cisplatin Cisplatin - pharmacology Creatinine Cullin Cullin Proteins - metabolism Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Genes Humans Immunohistochemistry Immunology Inflammation Ischemia Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Life Sciences Male Medicine Mice Mice, Inbred C57BL Morbidity Mortality p53 Protein Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Proteins Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - pathology Sepsis Serpin E2 Signal Transduction Transcriptomes Tumor Suppressor Protein p53 - metabolism Ubiquitin-protein ligase Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!