Incidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country
To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR). This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute...
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| Veröffentlicht in: | Pakistan journal of medical sciences 2024-12, Vol.40 (12PINS Suppl), p.S20-S24 |
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| container_issue | 12PINS Suppl |
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| container_title | Pakistan journal of medical sciences |
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| creator | Kiran, Sumira Ikram, Shuja Khizar, Ahtesham Iftikhar, Muhammad Kaleem Qadri, Haseeb Mehmood Umer, Muhammad Waqas Anwar, Khawar Bashir, Asif |
| description | To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR).
This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.
Among the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.
Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak. |
| doi_str_mv | 10.12669/pjms.40.12(PINS).11109 |
| format | Article |
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This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.
Among the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.
Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.40.12(PINS).11109</identifier><identifier>PMID: 39703967</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Anxiety ; Diabetic neuropathy ; Fibromyalgia ; General anesthesia ; Hyperthermia ; Intubation ; Jaw ; Laryngoscopy ; Mouth ; Muscle pain ; Original ; Patients ; Postwar reconstruction ; Serotonin ; Surgery</subject><ispartof>Pakistan journal of medical sciences, 2024-12, Vol.40 (12PINS Suppl), p.S20-S24</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654658/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654658/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39703967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiran, Sumira</creatorcontrib><creatorcontrib>Ikram, Shuja</creatorcontrib><creatorcontrib>Khizar, Ahtesham</creatorcontrib><creatorcontrib>Iftikhar, Muhammad Kaleem</creatorcontrib><creatorcontrib>Qadri, Haseeb Mehmood</creatorcontrib><creatorcontrib>Umer, Muhammad Waqas</creatorcontrib><creatorcontrib>Anwar, Khawar</creatorcontrib><creatorcontrib>Bashir, Asif</creatorcontrib><title>Incidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR).
This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.
Among the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.
Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.</description><subject>Anxiety</subject><subject>Diabetic neuropathy</subject><subject>Fibromyalgia</subject><subject>General anesthesia</subject><subject>Hyperthermia</subject><subject>Intubation</subject><subject>Jaw</subject><subject>Laryngoscopy</subject><subject>Mouth</subject><subject>Muscle pain</subject><subject>Original</subject><subject>Patients</subject><subject>Postwar reconstruction</subject><subject>Serotonin</subject><subject>Surgery</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt1u1DAQhSMEoqXwCmAJCZWLLHHsOHFvUFXxU6kCJEDqneU4k65L4gm2s1UfmPfA2ZbSRSgX8djfnGPPTJa9oMWKlkLIN9PlGFZ8iQ6_nH76-npFKS3kg2yfiobmNa3OH27XZV6U_HwvexLCZVFwwavycbbHZF0wKer97NepM7YDZ4BgTyYMESfwOtoNEAMeWo9hsk4PpB9m25EB9I9ArCPgOgwGJ2u2S6dDYqLXLoRpDQ5tl-Iw-wvw16RHTyYbZxt1inTyw1EHcmXjGudIAgyD9skBE-fBoAvRzyZadEfkOO3E5RZgtrfCNoDf6OVwcYhzl_Q9jkSTAa_y0XbdALl1Bsf0BJxd9NdPs0e9HgI8u_0fZN_fv_t28jE_-_zh9OT4LDeMcZkLCXWjO24otE1XyNa0fSObStQaBJSyaQUApU3BhKFSVNCUdcW57lqqSykYO8je3uhOcztCZyCZ60FN3o7p4Qq1Vbsnzq7VBW4UpaLiomqSwuGtgsefM4SoRhvMUh8HOAfFKK95IzitE_ryH_QSZ5-KslAsQaxi4i91oQdQ1vWYjM0iqo4bKnlZsUYmavUfKn0djDb1A3qb9ncSXt1LWIMe4jrgMC9tCbtgfQOa1MPgob-rBi3UdpbVMsuKL5FaZlmp7SynzOf3i3mX92d42W-Q_PmH</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Kiran, Sumira</creator><creator>Ikram, Shuja</creator><creator>Khizar, Ahtesham</creator><creator>Iftikhar, Muhammad Kaleem</creator><creator>Qadri, Haseeb Mehmood</creator><creator>Umer, Muhammad Waqas</creator><creator>Anwar, Khawar</creator><creator>Bashir, Asif</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241231</creationdate><title>Incidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country</title><author>Kiran, Sumira ; Ikram, Shuja ; Khizar, Ahtesham ; Iftikhar, Muhammad Kaleem ; Qadri, Haseeb Mehmood ; Umer, Muhammad Waqas ; Anwar, Khawar ; Bashir, Asif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3349-69e78ad4c1eb8d09bcbf898567ae6e298b6ee118036c1965e827544adb1a29633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety</topic><topic>Diabetic neuropathy</topic><topic>Fibromyalgia</topic><topic>General anesthesia</topic><topic>Hyperthermia</topic><topic>Intubation</topic><topic>Jaw</topic><topic>Laryngoscopy</topic><topic>Mouth</topic><topic>Muscle pain</topic><topic>Original</topic><topic>Patients</topic><topic>Postwar reconstruction</topic><topic>Serotonin</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiran, Sumira</creatorcontrib><creatorcontrib>Ikram, Shuja</creatorcontrib><creatorcontrib>Khizar, Ahtesham</creatorcontrib><creatorcontrib>Iftikhar, Muhammad Kaleem</creatorcontrib><creatorcontrib>Qadri, Haseeb Mehmood</creatorcontrib><creatorcontrib>Umer, Muhammad Waqas</creatorcontrib><creatorcontrib>Anwar, Khawar</creatorcontrib><creatorcontrib>Bashir, Asif</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiran, Sumira</au><au>Ikram, Shuja</au><au>Khizar, Ahtesham</au><au>Iftikhar, Muhammad Kaleem</au><au>Qadri, Haseeb Mehmood</au><au>Umer, Muhammad Waqas</au><au>Anwar, Khawar</au><au>Bashir, Asif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>40</volume><issue>12PINS Suppl</issue><spage>S20</spage><epage>S24</epage><pages>S20-S24</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR).
This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.
Among the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.
Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>39703967</pmid><doi>10.12669/pjms.40.12(PINS).11109</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Anxiety Diabetic neuropathy Fibromyalgia General anesthesia Hyperthermia Intubation Jaw Laryngoscopy Mouth Muscle pain Original Patients Postwar reconstruction Serotonin Surgery |
| title | Incidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country |
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