Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats
The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of t...
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| Veröffentlicht in: | Acta Cirúrgica Brasileira 2024-01, Vol.39, p.e399624 |
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| creator | Doci, Rosana Soares Araújo Carvalho, Filipe Feitosa de Gomes, Rodrigo César Gianini, Reinaldo José Fanelli, Camilla Noronha, Irene de Lourdes Santos, Nelson Brancaccio Dos Hausen, Moema de Alencar Komatsu, Daniel Randazzo-Moura, Priscila |
| description | The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats.
Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.
The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.
This association is a powerful and innovative pharmacological tool, promising in translational medicine. |
| doi_str_mv | 10.1590/acb399624 |
| format | Article |
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Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.
The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.
This association is a powerful and innovative pharmacological tool, promising in translational medicine.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>DOI: 10.1590/acb399624</identifier><identifier>PMID: 39661810</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</publisher><subject>Adhesives ; Adrenal Cortex Hormones ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Biocompatible Materials ; Cyanoacrylates ; Male ; Original ; Rats ; Rats, Wistar ; Reproducibility of Results ; Skin - drug effects ; Skin - injuries ; Surgical Wound - drug therapy ; Time Factors ; Tissue Adhesives - pharmacology ; Tissue Adhesives - therapeutic use ; Triamcinolone - pharmacology ; Triamcinolone - therapeutic use ; Wound Healing - drug effects</subject><ispartof>Acta Cirúrgica Brasileira, 2024-01, Vol.39, p.e399624</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c297t-f28bb782fda33c1c6b3f7dcda1f2e13ba6399ac72bb3b4ed2323ec95f2264ae03</cites><orcidid>0009-0004-3857-3274 ; 0000-0002-7131-4045 ; 0009-0009-1971-1850 ; 0000-0002-7472-8315 ; 0000-0002-7046-7306 ; 0000-0003-4425-7708 ; 0000-0001-7672-6084 ; 0000-0002-3357-9739 ; 0000-0002-3208-4435 ; 0000-0002-2441-8650</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653989/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653989/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39661810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doci, Rosana Soares Araújo</creatorcontrib><creatorcontrib>Carvalho, Filipe Feitosa de</creatorcontrib><creatorcontrib>Gomes, Rodrigo César</creatorcontrib><creatorcontrib>Gianini, Reinaldo José</creatorcontrib><creatorcontrib>Fanelli, Camilla</creatorcontrib><creatorcontrib>Noronha, Irene de Lourdes</creatorcontrib><creatorcontrib>Santos, Nelson Brancaccio Dos</creatorcontrib><creatorcontrib>Hausen, Moema de Alencar</creatorcontrib><creatorcontrib>Komatsu, Daniel</creatorcontrib><creatorcontrib>Randazzo-Moura, Priscila</creatorcontrib><title>Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats</title><title>Acta Cirúrgica Brasileira</title><addtitle>Acta Cir Bras</addtitle><description>The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats.
Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.
The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.
This association is a powerful and innovative pharmacological tool, promising in translational medicine.</description><subject>Adhesives</subject><subject>Adrenal Cortex Hormones</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biocompatible Materials</subject><subject>Cyanoacrylates</subject><subject>Male</subject><subject>Original</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Skin - drug effects</subject><subject>Skin - injuries</subject><subject>Surgical Wound - drug therapy</subject><subject>Time Factors</subject><subject>Tissue Adhesives - pharmacology</subject><subject>Tissue Adhesives - therapeutic use</subject><subject>Triamcinolone - pharmacology</subject><subject>Triamcinolone - therapeutic use</subject><subject>Wound Healing - drug effects</subject><issn>0102-8650</issn><issn>1678-2674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVkU9v1DAQxS1ERZfCgS-AfOUQ8L84zgmhipZKlegBztZ4YmddZe3Kdqj49gQWVvQ00rz3fqPRI-QNZ-95P7IPgE6OoxbqGdlxPZhO6EE9JzvGmeiM7tk5eVnrPWNcaS5fkHM5as0NZzsS7_ZQDoB5yXNEWKgPwWOrNAfaSoQDxrRpyVOoNWOE5if6GNue1rUcE_OyepoTxbVB8nmt9DGvaaJ7D0tMM42JFmj1FTkLsFT_-u-8IN-vPn-7_NLdfr2-ufx026EYh9YFYZwbjAgTSIkctZNhmHACHoTn0oHeXgUchHPSKT8JKaTHsQ9CaAWeyQtyc-ROGe7tQ4kHKD9thmj_LHKZLZQWcfF2g2mmnECNXvVcO6XQm2CEMopzJTfWxyPrYXUHP6FPrcDyBPpUSXFv5_zDcq57OZpxI7w7ErDkWosPpzBn9nd59lTe5n37_7WT819b8hc8DJiK</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Doci, Rosana Soares Araújo</creator><creator>Carvalho, Filipe Feitosa de</creator><creator>Gomes, Rodrigo César</creator><creator>Gianini, Reinaldo José</creator><creator>Fanelli, Camilla</creator><creator>Noronha, Irene de Lourdes</creator><creator>Santos, Nelson Brancaccio Dos</creator><creator>Hausen, Moema de Alencar</creator><creator>Komatsu, Daniel</creator><creator>Randazzo-Moura, Priscila</creator><general>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0009-0004-3857-3274</orcidid><orcidid>https://orcid.org/0000-0002-7131-4045</orcidid><orcidid>https://orcid.org/0009-0009-1971-1850</orcidid><orcidid>https://orcid.org/0000-0002-7472-8315</orcidid><orcidid>https://orcid.org/0000-0002-7046-7306</orcidid><orcidid>https://orcid.org/0000-0003-4425-7708</orcidid><orcidid>https://orcid.org/0000-0001-7672-6084</orcidid><orcidid>https://orcid.org/0000-0002-3357-9739</orcidid><orcidid>https://orcid.org/0000-0002-3208-4435</orcidid><orcidid>https://orcid.org/0000-0002-2441-8650</orcidid></search><sort><creationdate>20240101</creationdate><title>Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats</title><author>Doci, Rosana Soares Araújo ; Carvalho, Filipe Feitosa de ; Gomes, Rodrigo César ; Gianini, Reinaldo José ; Fanelli, Camilla ; Noronha, Irene de Lourdes ; Santos, Nelson Brancaccio Dos ; Hausen, Moema de Alencar ; Komatsu, Daniel ; Randazzo-Moura, Priscila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c297t-f28bb782fda33c1c6b3f7dcda1f2e13ba6399ac72bb3b4ed2323ec95f2264ae03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adhesives</topic><topic>Adrenal Cortex Hormones</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biocompatible Materials</topic><topic>Cyanoacrylates</topic><topic>Male</topic><topic>Original</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproducibility of Results</topic><topic>Skin - drug effects</topic><topic>Skin - injuries</topic><topic>Surgical Wound - drug therapy</topic><topic>Time Factors</topic><topic>Tissue Adhesives - pharmacology</topic><topic>Tissue Adhesives - therapeutic use</topic><topic>Triamcinolone - pharmacology</topic><topic>Triamcinolone - therapeutic use</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doci, Rosana Soares Araújo</creatorcontrib><creatorcontrib>Carvalho, Filipe Feitosa de</creatorcontrib><creatorcontrib>Gomes, Rodrigo César</creatorcontrib><creatorcontrib>Gianini, Reinaldo José</creatorcontrib><creatorcontrib>Fanelli, Camilla</creatorcontrib><creatorcontrib>Noronha, Irene de Lourdes</creatorcontrib><creatorcontrib>Santos, Nelson Brancaccio Dos</creatorcontrib><creatorcontrib>Hausen, Moema de Alencar</creatorcontrib><creatorcontrib>Komatsu, Daniel</creatorcontrib><creatorcontrib>Randazzo-Moura, Priscila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Acta Cirúrgica Brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doci, Rosana Soares Araújo</au><au>Carvalho, Filipe Feitosa de</au><au>Gomes, Rodrigo César</au><au>Gianini, Reinaldo José</au><au>Fanelli, Camilla</au><au>Noronha, Irene de Lourdes</au><au>Santos, Nelson Brancaccio Dos</au><au>Hausen, Moema de Alencar</au><au>Komatsu, Daniel</au><au>Randazzo-Moura, Priscila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats</atitle><jtitle>Acta Cirúrgica Brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>39</volume><spage>e399624</spage><pages>e399624-</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><abstract>The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats.
Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.
The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.
This association is a powerful and innovative pharmacological tool, promising in translational medicine.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</pub><pmid>39661810</pmid><doi>10.1590/acb399624</doi><orcidid>https://orcid.org/0009-0004-3857-3274</orcidid><orcidid>https://orcid.org/0000-0002-7131-4045</orcidid><orcidid>https://orcid.org/0009-0009-1971-1850</orcidid><orcidid>https://orcid.org/0000-0002-7472-8315</orcidid><orcidid>https://orcid.org/0000-0002-7046-7306</orcidid><orcidid>https://orcid.org/0000-0003-4425-7708</orcidid><orcidid>https://orcid.org/0000-0001-7672-6084</orcidid><orcidid>https://orcid.org/0000-0002-3357-9739</orcidid><orcidid>https://orcid.org/0000-0002-3208-4435</orcidid><orcidid>https://orcid.org/0000-0002-2441-8650</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adhesives Adrenal Cortex Hormones Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biocompatible Materials Cyanoacrylates Male Original Rats Rats, Wistar Reproducibility of Results Skin - drug effects Skin - injuries Surgical Wound - drug therapy Time Factors Tissue Adhesives - pharmacology Tissue Adhesives - therapeutic use Triamcinolone - pharmacology Triamcinolone - therapeutic use Wound Healing - drug effects |
| title | Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats |
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