Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study
Aim The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population‐based cohort with dental examination and brain magnetic resonance imaging...
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| Veröffentlicht in: | Journal of clinical periodontology 2024-12, Vol.51 (12), p.1598-1609 |
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| creator | Mayer, Carola Walther, Carolin Borof, Katrin Nägele, Felix L. Petersen, Marvin Schell, Maximilian Gerloff, Christian Kühn, Simone Heydecke, Guido Beikler, Thomas Cheng, Bastian Thomalla, Götz Aarabi, Ghazal |
| description | Aim
The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population‐based cohort with dental examination and brain magnetic resonance imaging (MRI).
Materials and Methods
Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D‐FLAIR and 3D‐T1‐weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion‐weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).
Results
Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p |
| doi_str_mv | 10.1111/jcpe.13828 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11651723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2822378607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4498-210850572a75884c43872ece265a47500b20875babeadd7966c92d5dda5212b13</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhoModq3e-AMk4I0I0-ZjMslcSVmqaylUUMG7kElOu1lmkjXJWPbfN9utRb0wNyGch4f35EXoNSUntJ7Tjd3CCeWKqSdoQTtCGiLoj6doQTjhTdfL_gi9yHlDCJWc8-foiEvW8Y61CxTOco7Wm-JjwAOUW4CAt5B8dDEUM2LnM5gM2ASHJ29TzCXNtsypzoZkfMBmLJDuBRnXZ1kDXplpmNMNXvqywyuoxBp_LbPbvUTPrs2Y4dXDfYy-fzz_tlw1l1efPi_PLhvbtr1qGCVKECGZkUKp1rZcSQYWWCdMKwUhAyNKisEMYJyTfdfZnjnhnBGMsoHyY_Th4N3OwwTOQig1sN4mP5m009F4_fck-LW-ib80pZ2gkvFqePdgSPHnDLnoyWcL42gCxDlrphjjUnVEVvTtP-gmzinU_TSnrVCciVZV6v2B2v9hTnD9mIYSve9R73vU9z1W-M2f-R_R38VVgB6AWz_C7j8qfbH8cn6Q3gFVAKnH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3145832548</pqid></control><display><type>article</type><title>Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mayer, Carola ; Walther, Carolin ; Borof, Katrin ; Nägele, Felix L. ; Petersen, Marvin ; Schell, Maximilian ; Gerloff, Christian ; Kühn, Simone ; Heydecke, Guido ; Beikler, Thomas ; Cheng, Bastian ; Thomalla, Götz ; Aarabi, Ghazal</creator><creatorcontrib>Mayer, Carola ; Walther, Carolin ; Borof, Katrin ; Nägele, Felix L. ; Petersen, Marvin ; Schell, Maximilian ; Gerloff, Christian ; Kühn, Simone ; Heydecke, Guido ; Beikler, Thomas ; Cheng, Bastian ; Thomalla, Götz ; Aarabi, Ghazal</creatorcontrib><description>Aim
The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population‐based cohort with dental examination and brain magnetic resonance imaging (MRI).
Materials and Methods
Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D‐FLAIR and 3D‐T1‐weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion‐weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).
Results
Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p < .001) and DMFT (p < .01), whereas effects of WMH load were attenuated (p > .05).
Conclusions
These findings suggest an adverse effect of periodontal health on CSVD and white matter integrity. Further research is necessary to examine whether early treatment of periodontal disease can prevent microstructural brain damage.</description><identifier>ISSN: 0303-6979</identifier><identifier>ISSN: 1600-051X</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13828</identifier><identifier>PMID: 37263624</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Brain - diagnostic imaging ; Brain - pathology ; Brain injury ; Cardiovascular diseases ; cerebral small vessel disease ; Cerebral Small Vessel Diseases - complications ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - pathology ; Cohort Studies ; Dental Plaque Index ; Diagnosis, Epidemiology and Associated Co‐morbidities ; diffusion magnetic resonance imaging ; DMF Index ; Female ; Germany - epidemiology ; Gum disease ; Humans ; Image processing ; Magnetic Resonance Imaging ; Male ; Middle Aged ; neurodegenerative diseases ; Neuroimaging ; oral health ; Original ; Periodontal diseases ; Periodontal Diseases - complications ; Periodontal Diseases - diagnostic imaging ; Periodontal Diseases - pathology ; Plaque index ; Population studies ; Risk Factors ; Substantia alba ; Vascular diseases ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Journal of clinical periodontology, 2024-12, Vol.51 (12), p.1598-1609</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4498-210850572a75884c43872ece265a47500b20875babeadd7966c92d5dda5212b13</citedby><cites>FETCH-LOGICAL-c4498-210850572a75884c43872ece265a47500b20875babeadd7966c92d5dda5212b13</cites><orcidid>0000-0002-8065-8683 ; 0000-0002-1307-5672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.13828$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.13828$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37263624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mayer, Carola</creatorcontrib><creatorcontrib>Walther, Carolin</creatorcontrib><creatorcontrib>Borof, Katrin</creatorcontrib><creatorcontrib>Nägele, Felix L.</creatorcontrib><creatorcontrib>Petersen, Marvin</creatorcontrib><creatorcontrib>Schell, Maximilian</creatorcontrib><creatorcontrib>Gerloff, Christian</creatorcontrib><creatorcontrib>Kühn, Simone</creatorcontrib><creatorcontrib>Heydecke, Guido</creatorcontrib><creatorcontrib>Beikler, Thomas</creatorcontrib><creatorcontrib>Cheng, Bastian</creatorcontrib><creatorcontrib>Thomalla, Götz</creatorcontrib><creatorcontrib>Aarabi, Ghazal</creatorcontrib><title>Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population‐based cohort with dental examination and brain magnetic resonance imaging (MRI).
Materials and Methods
Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D‐FLAIR and 3D‐T1‐weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion‐weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).
Results
Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p < .001) and DMFT (p < .01), whereas effects of WMH load were attenuated (p > .05).
Conclusions
These findings suggest an adverse effect of periodontal health on CSVD and white matter integrity. Further research is necessary to examine whether early treatment of periodontal disease can prevent microstructural brain damage.</description><subject>Aged</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain injury</subject><subject>Cardiovascular diseases</subject><subject>cerebral small vessel disease</subject><subject>Cerebral Small Vessel Diseases - complications</subject><subject>Cerebral Small Vessel Diseases - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - pathology</subject><subject>Cohort Studies</subject><subject>Dental Plaque Index</subject><subject>Diagnosis, Epidemiology and Associated Co‐morbidities</subject><subject>diffusion magnetic resonance imaging</subject><subject>DMF Index</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Image processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>oral health</subject><subject>Original</subject><subject>Periodontal diseases</subject><subject>Periodontal Diseases - complications</subject><subject>Periodontal Diseases - diagnostic imaging</subject><subject>Periodontal Diseases - pathology</subject><subject>Plaque index</subject><subject>Population studies</subject><subject>Risk Factors</subject><subject>Substantia alba</subject><subject>Vascular diseases</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0303-6979</issn><issn>1600-051X</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModq3e-AMk4I0I0-ZjMslcSVmqaylUUMG7kElOu1lmkjXJWPbfN9utRb0wNyGch4f35EXoNSUntJ7Tjd3CCeWKqSdoQTtCGiLoj6doQTjhTdfL_gi9yHlDCJWc8-foiEvW8Y61CxTOco7Wm-JjwAOUW4CAt5B8dDEUM2LnM5gM2ASHJ29TzCXNtsypzoZkfMBmLJDuBRnXZ1kDXplpmNMNXvqywyuoxBp_LbPbvUTPrs2Y4dXDfYy-fzz_tlw1l1efPi_PLhvbtr1qGCVKECGZkUKp1rZcSQYWWCdMKwUhAyNKisEMYJyTfdfZnjnhnBGMsoHyY_Th4N3OwwTOQig1sN4mP5m009F4_fck-LW-ib80pZ2gkvFqePdgSPHnDLnoyWcL42gCxDlrphjjUnVEVvTtP-gmzinU_TSnrVCciVZV6v2B2v9hTnD9mIYSve9R73vU9z1W-M2f-R_R38VVgB6AWz_C7j8qfbH8cn6Q3gFVAKnH</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Mayer, Carola</creator><creator>Walther, Carolin</creator><creator>Borof, Katrin</creator><creator>Nägele, Felix L.</creator><creator>Petersen, Marvin</creator><creator>Schell, Maximilian</creator><creator>Gerloff, Christian</creator><creator>Kühn, Simone</creator><creator>Heydecke, Guido</creator><creator>Beikler, Thomas</creator><creator>Cheng, Bastian</creator><creator>Thomalla, Götz</creator><creator>Aarabi, Ghazal</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8065-8683</orcidid><orcidid>https://orcid.org/0000-0002-1307-5672</orcidid></search><sort><creationdate>202412</creationdate><title>Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study</title><author>Mayer, Carola ; Walther, Carolin ; Borof, Katrin ; Nägele, Felix L. ; Petersen, Marvin ; Schell, Maximilian ; Gerloff, Christian ; Kühn, Simone ; Heydecke, Guido ; Beikler, Thomas ; Cheng, Bastian ; Thomalla, Götz ; Aarabi, Ghazal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4498-210850572a75884c43872ece265a47500b20875babeadd7966c92d5dda5212b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain injury</topic><topic>Cardiovascular diseases</topic><topic>cerebral small vessel disease</topic><topic>Cerebral Small Vessel Diseases - complications</topic><topic>Cerebral Small Vessel Diseases - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - pathology</topic><topic>Cohort Studies</topic><topic>Dental Plaque Index</topic><topic>Diagnosis, Epidemiology and Associated Co‐morbidities</topic><topic>diffusion magnetic resonance imaging</topic><topic>DMF Index</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Image processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>oral health</topic><topic>Original</topic><topic>Periodontal diseases</topic><topic>Periodontal Diseases - complications</topic><topic>Periodontal Diseases - diagnostic imaging</topic><topic>Periodontal Diseases - pathology</topic><topic>Plaque index</topic><topic>Population studies</topic><topic>Risk Factors</topic><topic>Substantia alba</topic><topic>Vascular diseases</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayer, Carola</creatorcontrib><creatorcontrib>Walther, Carolin</creatorcontrib><creatorcontrib>Borof, Katrin</creatorcontrib><creatorcontrib>Nägele, Felix L.</creatorcontrib><creatorcontrib>Petersen, Marvin</creatorcontrib><creatorcontrib>Schell, Maximilian</creatorcontrib><creatorcontrib>Gerloff, Christian</creatorcontrib><creatorcontrib>Kühn, Simone</creatorcontrib><creatorcontrib>Heydecke, Guido</creatorcontrib><creatorcontrib>Beikler, Thomas</creatorcontrib><creatorcontrib>Cheng, Bastian</creatorcontrib><creatorcontrib>Thomalla, Götz</creatorcontrib><creatorcontrib>Aarabi, Ghazal</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayer, Carola</au><au>Walther, Carolin</au><au>Borof, Katrin</au><au>Nägele, Felix L.</au><au>Petersen, Marvin</au><au>Schell, Maximilian</au><au>Gerloff, Christian</au><au>Kühn, Simone</au><au>Heydecke, Guido</au><au>Beikler, Thomas</au><au>Cheng, Bastian</au><au>Thomalla, Götz</au><au>Aarabi, Ghazal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>51</volume><issue>12</issue><spage>1598</spage><epage>1609</epage><pages>1598-1609</pages><issn>0303-6979</issn><issn>1600-051X</issn><eissn>1600-051X</eissn><abstract>Aim
The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population‐based cohort with dental examination and brain magnetic resonance imaging (MRI).
Materials and Methods
Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D‐FLAIR and 3D‐T1‐weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion‐weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).
Results
Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p < .001) and DMFT (p < .01), whereas effects of WMH load were attenuated (p > .05).
Conclusions
These findings suggest an adverse effect of periodontal health on CSVD and white matter integrity. Further research is necessary to examine whether early treatment of periodontal disease can prevent microstructural brain damage.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>37263624</pmid><doi>10.1111/jcpe.13828</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8065-8683</orcidid><orcidid>https://orcid.org/0000-0002-1307-5672</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Brain - diagnostic imaging Brain - pathology Brain injury Cardiovascular diseases cerebral small vessel disease Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - pathology Cohort Studies Dental Plaque Index Diagnosis, Epidemiology and Associated Co‐morbidities diffusion magnetic resonance imaging DMF Index Female Germany - epidemiology Gum disease Humans Image processing Magnetic Resonance Imaging Male Middle Aged neurodegenerative diseases Neuroimaging oral health Original Periodontal diseases Periodontal Diseases - complications Periodontal Diseases - diagnostic imaging Periodontal Diseases - pathology Plaque index Population studies Risk Factors Substantia alba Vascular diseases White Matter - diagnostic imaging White Matter - pathology |
| title | Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study |
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