Structure Elucidation of the Daptomycin Products Generated upon Heterologous Expression of the Daptomycin Resistance Gene Cluster drcAB

Recently, a high-level daptomycin (DAP)-resistant Mammaliicoccus sciuri strain (TS92) was identified, which mediates a 33% decline of DAP when incubated in Mueller-Hinton (MH) medium. The genetic background of the DAP resistance in TS92 is a newly discovered two-gene operon, named drcAB, whose expre...

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Veröffentlicht in:	ACS infectious diseases 2024-12, Vol.10 (12), p.4271-4278
Hauptverfasser:	Kirchner, Lukas, Marciniak, Tessa, Erk, Christine, Ziebuhr, Wilma, Scherf-Clavel, Oliver, Holzgrabe, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Daptomycin - chemistry Daptomycin - pharmacology Drug Resistance, Bacterial Gene Expression Regulation, Bacterial Mass Spectrometry Microbial Sensitivity Tests Multigene Family Operon Staphylococcus aureus - drug effects Staphylococcus aureus - genetics
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