Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis
Introduction Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited. Methods Patients from a large US hospital system undergoing combined LAAO and left‐atrial CA from 8/2020 to 2/2024 were...
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| Veröffentlicht in: | Journal of cardiovascular electrophysiology 2024-12, Vol.35 (12), p.2423-2431 |
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| creator | Preisendörfer, Stefan Ayub, Muhammad T. Sheth, Aakash Jabbour, George Y. Singh, Madhurmeet Patel, Chinmay P. Gada, Hemal Bhonsale, Aditya Dhande, Mehak Estes, Nathan A. Kancharla, Krishna Kliner, Dustin E. Makani, Amber Naniwadekar, Aditi Shalaby, Alaa Singla, Virginia Voigt, Andrew Saba, Samir F. Jain, Sandeep K. |
| description | Introduction
Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.
Methods
Patients from a large US hospital system undergoing combined LAAO and left‐atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs. Amulet), CHA2D2‐VASc and Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio [INR], Elderly, Drugs/alcohol (HAS‐BLED) scores and compared for safety, sealing performance and clinical outcomes at 6 months.
Results
Patients were younger in the combined (n = 72) than in the control group (n = 144, 70.2 ± 7.3 vs. 76.7 ± 6.9 years, p |
| doi_str_mv | 10.1111/jce.16466 |
| format | Article |
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Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.
Methods
Patients from a large US hospital system undergoing combined LAAO and left‐atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs. Amulet), CHA2D2‐VASc and Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio [INR], Elderly, Drugs/alcohol (HAS‐BLED) scores and compared for safety, sealing performance and clinical outcomes at 6 months.
Results
Patients were younger in the combined (n = 72) than in the control group (n = 144, 70.2 ± 7.3 vs. 76.7 ± 6.9 years, p < 0.001) but otherwise comparable with a mean CHA2D2‐VASc score of 4.2 ± 1.1 and 4.4 ± 1.2 (p = 0.26) and HAS‐BLED score of 2.2 ± 0.8 and 2.3 ± 0.7 (p = 0.34). Successful LAAO implantation rates were the same (95.8% vs. 95.8%, p = 0.99) with longer procedure times seen in the combined group (156.5 ± 53 vs. 56 ± 26 min, p < 0.001). Both major (1.4% vs. 2.1%, p = 0.72) and minor (27.8% vs. 19.4%, p = 0.17) in‐hospital complications were similar between the combined and control group, respectively. At 45 days, presence of peri‐device leak (18.3% vs. 30.4%, p = 0.07) and device related thrombosis (4.5% vs. 4.5%, p = 0.96) on transesophageal echocardiogram did not differ. Finally, all‐cause mortality (0% vs. 1.4%, p = 0.99), thromboembolic (0% vs. 0%, p = 0.99) and bleeding (6.1% vs. 4.4%, p = 0.73) events during follow‐up were comparable.
Conclusion
This large, real‐world analysis indicates comparable safety and efficiency of combined LAAO and CA when compared with LAAO alone.</description><identifier>ISSN: 1045-3873</identifier><identifier>ISSN: 1540-8167</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/jce.16466</identifier><identifier>PMID: 39407419</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Ablation ; Action Potentials ; Aged ; Aged, 80 and over ; Arrhythmia ; Atrial Appendage - physiopathology ; Atrial Appendage - surgery ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Atrial Function, Left ; Bleeding ; Cardiac Catheterization - adverse effects ; Cardiac Catheterization - instrumentation ; catheter ablation ; Catheter Ablation - adverse effects ; Catheters ; Combined Modality Therapy ; combined procedure ; Echocardiography ; Female ; Heart Rate ; Humans ; left atrial appendage occlusion ; Male ; Middle Aged ; Occlusion ; Original ; Patients ; Propensity Score ; pulmonary vein isolation ; Radiofrequency ablation ; Renal function ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Thromboembolism ; Thrombosis ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of cardiovascular electrophysiology, 2024-12, Vol.35 (12), p.2423-2431</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3346-35e2c844bd78bf681a7482d7ab36d1e38085398899fe1670ac9326169b6e183</cites><orcidid>0000-0002-5815-370X ; 0000-0002-5461-7247 ; 0000-0003-4669-803X ; 0000-0002-2000-7678 ; 0000-0003-2320-5175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjce.16466$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjce.16466$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39407419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Preisendörfer, Stefan</creatorcontrib><creatorcontrib>Ayub, Muhammad T.</creatorcontrib><creatorcontrib>Sheth, Aakash</creatorcontrib><creatorcontrib>Jabbour, George Y.</creatorcontrib><creatorcontrib>Singh, Madhurmeet</creatorcontrib><creatorcontrib>Patel, Chinmay P.</creatorcontrib><creatorcontrib>Gada, Hemal</creatorcontrib><creatorcontrib>Bhonsale, Aditya</creatorcontrib><creatorcontrib>Dhande, Mehak</creatorcontrib><creatorcontrib>Estes, Nathan A.</creatorcontrib><creatorcontrib>Kancharla, Krishna</creatorcontrib><creatorcontrib>Kliner, Dustin E.</creatorcontrib><creatorcontrib>Makani, Amber</creatorcontrib><creatorcontrib>Naniwadekar, Aditi</creatorcontrib><creatorcontrib>Shalaby, Alaa</creatorcontrib><creatorcontrib>Singla, Virginia</creatorcontrib><creatorcontrib>Voigt, Andrew</creatorcontrib><creatorcontrib>Saba, Samir F.</creatorcontrib><creatorcontrib>Jain, Sandeep K.</creatorcontrib><title>Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Introduction
Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.
Methods
Patients from a large US hospital system undergoing combined LAAO and left‐atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs. Amulet), CHA2D2‐VASc and Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio [INR], Elderly, Drugs/alcohol (HAS‐BLED) scores and compared for safety, sealing performance and clinical outcomes at 6 months.
Results
Patients were younger in the combined (n = 72) than in the control group (n = 144, 70.2 ± 7.3 vs. 76.7 ± 6.9 years, p < 0.001) but otherwise comparable with a mean CHA2D2‐VASc score of 4.2 ± 1.1 and 4.4 ± 1.2 (p = 0.26) and HAS‐BLED score of 2.2 ± 0.8 and 2.3 ± 0.7 (p = 0.34). Successful LAAO implantation rates were the same (95.8% vs. 95.8%, p = 0.99) with longer procedure times seen in the combined group (156.5 ± 53 vs. 56 ± 26 min, p < 0.001). Both major (1.4% vs. 2.1%, p = 0.72) and minor (27.8% vs. 19.4%, p = 0.17) in‐hospital complications were similar between the combined and control group, respectively. At 45 days, presence of peri‐device leak (18.3% vs. 30.4%, p = 0.07) and device related thrombosis (4.5% vs. 4.5%, p = 0.96) on transesophageal echocardiogram did not differ. Finally, all‐cause mortality (0% vs. 1.4%, p = 0.99), thromboembolic (0% vs. 0%, p = 0.99) and bleeding (6.1% vs. 4.4%, p = 0.73) events during follow‐up were comparable.
Conclusion
This large, real‐world analysis indicates comparable safety and efficiency of combined LAAO and CA when compared with LAAO alone.</description><subject>Ablation</subject><subject>Action Potentials</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arrhythmia</subject><subject>Atrial Appendage - physiopathology</subject><subject>Atrial Appendage - surgery</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Atrial Function, Left</subject><subject>Bleeding</subject><subject>Cardiac Catheterization - adverse effects</subject><subject>Cardiac Catheterization - instrumentation</subject><subject>catheter ablation</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheters</subject><subject>Combined Modality Therapy</subject><subject>combined procedure</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>left atrial appendage occlusion</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occlusion</subject><subject>Original</subject><subject>Patients</subject><subject>Propensity Score</subject><subject>pulmonary vein isolation</subject><subject>Radiofrequency ablation</subject><subject>Renal function</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1045-3873</issn><issn>1540-8167</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc1u1TAQhSMEoqWw4AVQJDZUIq197ThON6i6Kn-qxAL21sSZNL5y4mA7VNnxCJV4Q54Eh1sqioQ3tsafzxzPybLnlJzQtE53Gk-o4EI8yA5pyUkhqagepjPhZcFkxQ6yJyHsCKFMkPJxdsBqTipO68Psx9YNjRmxzS12MYfoDdgcpgnHFq4wd1rbORg35jC2uYbYY0SfQ2MhrtXJO43t7DHvnL-v4X2_xH4wEM7y89wj2J_fb66dt-3r9VnqEExcUm2AqPvkAEawSzDhafaoAxvw2e1-lH1-e_Fl-764_PTuw_b8stCMcVGwEjdact60lWw6ISlUXG7aChomWopMElmyWsq67jDNg4Cu2UZQUTcCqWRH2Zu96jQ3A7Yax-jBqsmbAfyiHBh1_2Y0vbpy3xSloiSclknh1a2Cd19nDFENJmi0FkZ0c1CM0iqNecNX9OU_6M7NPv13pXhZkppWK3W8p7R3IXjs7txQotakVUpa_U46sS_-tn9H_ok2Aad74NpYXP6vpD5uL_aSvwDi1bcc</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Preisendörfer, Stefan</creator><creator>Ayub, Muhammad T.</creator><creator>Sheth, Aakash</creator><creator>Jabbour, George Y.</creator><creator>Singh, Madhurmeet</creator><creator>Patel, Chinmay P.</creator><creator>Gada, Hemal</creator><creator>Bhonsale, Aditya</creator><creator>Dhande, Mehak</creator><creator>Estes, Nathan A.</creator><creator>Kancharla, Krishna</creator><creator>Kliner, Dustin E.</creator><creator>Makani, Amber</creator><creator>Naniwadekar, Aditi</creator><creator>Shalaby, Alaa</creator><creator>Singla, Virginia</creator><creator>Voigt, Andrew</creator><creator>Saba, Samir F.</creator><creator>Jain, Sandeep K.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5815-370X</orcidid><orcidid>https://orcid.org/0000-0002-5461-7247</orcidid><orcidid>https://orcid.org/0000-0003-4669-803X</orcidid><orcidid>https://orcid.org/0000-0002-2000-7678</orcidid><orcidid>https://orcid.org/0000-0003-2320-5175</orcidid></search><sort><creationdate>202412</creationdate><title>Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis</title><author>Preisendörfer, Stefan ; Ayub, Muhammad T. ; Sheth, Aakash ; Jabbour, George Y. ; Singh, Madhurmeet ; Patel, Chinmay P. ; Gada, Hemal ; Bhonsale, Aditya ; Dhande, Mehak ; Estes, Nathan A. ; Kancharla, Krishna ; Kliner, Dustin E. ; Makani, Amber ; Naniwadekar, Aditi ; Shalaby, Alaa ; Singla, Virginia ; Voigt, Andrew ; Saba, Samir F. ; Jain, Sandeep K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3346-35e2c844bd78bf681a7482d7ab36d1e38085398899fe1670ac9326169b6e183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ablation</topic><topic>Action Potentials</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arrhythmia</topic><topic>Atrial Appendage - physiopathology</topic><topic>Atrial Appendage - surgery</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Atrial Function, Left</topic><topic>Bleeding</topic><topic>Cardiac Catheterization - adverse effects</topic><topic>Cardiac Catheterization - instrumentation</topic><topic>catheter ablation</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheters</topic><topic>Combined Modality Therapy</topic><topic>combined procedure</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>left atrial appendage occlusion</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occlusion</topic><topic>Original</topic><topic>Patients</topic><topic>Propensity Score</topic><topic>pulmonary vein isolation</topic><topic>Radiofrequency ablation</topic><topic>Renal function</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Preisendörfer, Stefan</creatorcontrib><creatorcontrib>Ayub, Muhammad T.</creatorcontrib><creatorcontrib>Sheth, Aakash</creatorcontrib><creatorcontrib>Jabbour, George Y.</creatorcontrib><creatorcontrib>Singh, Madhurmeet</creatorcontrib><creatorcontrib>Patel, Chinmay P.</creatorcontrib><creatorcontrib>Gada, Hemal</creatorcontrib><creatorcontrib>Bhonsale, Aditya</creatorcontrib><creatorcontrib>Dhande, Mehak</creatorcontrib><creatorcontrib>Estes, Nathan A.</creatorcontrib><creatorcontrib>Kancharla, Krishna</creatorcontrib><creatorcontrib>Kliner, Dustin E.</creatorcontrib><creatorcontrib>Makani, Amber</creatorcontrib><creatorcontrib>Naniwadekar, Aditi</creatorcontrib><creatorcontrib>Shalaby, Alaa</creatorcontrib><creatorcontrib>Singla, Virginia</creatorcontrib><creatorcontrib>Voigt, Andrew</creatorcontrib><creatorcontrib>Saba, Samir F.</creatorcontrib><creatorcontrib>Jain, Sandeep K.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Preisendörfer, Stefan</au><au>Ayub, Muhammad T.</au><au>Sheth, Aakash</au><au>Jabbour, George Y.</au><au>Singh, Madhurmeet</au><au>Patel, Chinmay P.</au><au>Gada, Hemal</au><au>Bhonsale, Aditya</au><au>Dhande, Mehak</au><au>Estes, Nathan A.</au><au>Kancharla, Krishna</au><au>Kliner, Dustin E.</au><au>Makani, Amber</au><au>Naniwadekar, Aditi</au><au>Shalaby, Alaa</au><au>Singla, Virginia</au><au>Voigt, Andrew</au><au>Saba, Samir F.</au><au>Jain, Sandeep K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>35</volume><issue>12</issue><spage>2423</spage><epage>2431</epage><pages>2423-2431</pages><issn>1045-3873</issn><issn>1540-8167</issn><eissn>1540-8167</eissn><abstract>Introduction
Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.
Methods
Patients from a large US hospital system undergoing combined LAAO and left‐atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs. Amulet), CHA2D2‐VASc and Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio [INR], Elderly, Drugs/alcohol (HAS‐BLED) scores and compared for safety, sealing performance and clinical outcomes at 6 months.
Results
Patients were younger in the combined (n = 72) than in the control group (n = 144, 70.2 ± 7.3 vs. 76.7 ± 6.9 years, p < 0.001) but otherwise comparable with a mean CHA2D2‐VASc score of 4.2 ± 1.1 and 4.4 ± 1.2 (p = 0.26) and HAS‐BLED score of 2.2 ± 0.8 and 2.3 ± 0.7 (p = 0.34). Successful LAAO implantation rates were the same (95.8% vs. 95.8%, p = 0.99) with longer procedure times seen in the combined group (156.5 ± 53 vs. 56 ± 26 min, p < 0.001). Both major (1.4% vs. 2.1%, p = 0.72) and minor (27.8% vs. 19.4%, p = 0.17) in‐hospital complications were similar between the combined and control group, respectively. At 45 days, presence of peri‐device leak (18.3% vs. 30.4%, p = 0.07) and device related thrombosis (4.5% vs. 4.5%, p = 0.96) on transesophageal echocardiogram did not differ. Finally, all‐cause mortality (0% vs. 1.4%, p = 0.99), thromboembolic (0% vs. 0%, p = 0.99) and bleeding (6.1% vs. 4.4%, p = 0.73) events during follow‐up were comparable.
Conclusion
This large, real‐world analysis indicates comparable safety and efficiency of combined LAAO and CA when compared with LAAO alone.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39407419</pmid><doi>10.1111/jce.16466</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5815-370X</orcidid><orcidid>https://orcid.org/0000-0002-5461-7247</orcidid><orcidid>https://orcid.org/0000-0003-4669-803X</orcidid><orcidid>https://orcid.org/0000-0002-2000-7678</orcidid><orcidid>https://orcid.org/0000-0003-2320-5175</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1045-3873 |
| ispartof | Journal of cardiovascular electrophysiology, 2024-12, Vol.35 (12), p.2423-2431 |
| issn | 1045-3873 1540-8167 1540-8167 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11650415 |
| source | MEDLINE; Wiley Journals |
| subjects | Ablation Action Potentials Aged Aged, 80 and over Arrhythmia Atrial Appendage - physiopathology Atrial Appendage - surgery atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Atrial Function, Left Bleeding Cardiac Catheterization - adverse effects Cardiac Catheterization - instrumentation catheter ablation Catheter Ablation - adverse effects Catheters Combined Modality Therapy combined procedure Echocardiography Female Heart Rate Humans left atrial appendage occlusion Male Middle Aged Occlusion Original Patients Propensity Score pulmonary vein isolation Radiofrequency ablation Renal function Retrospective Studies Risk Assessment Risk Factors Thromboembolism Thrombosis Time Factors Treatment Outcome |
| title | Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis |
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