Decreased liver cytochrome P-450 in rats caused by norethindrone or ethynyloestradiol

1. 19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol (ethynyloestradiol) or 17beta-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one (norethindrone) but not 17alpha-ethyl-17beta-hydroxy-19-norandrost-4-en-3-one (norethandrolone) caused a time-dependent loss of cytochrome P-450 when incubated in vit...

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Veröffentlicht in:	Biochemical journal 1977-07, Vol.166 (1), p.57-64
Hauptverfasser:	White, I N, Muller-Eberhard, U
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinate Synthetase - biosynthesis Animals Cytochrome P-450 Enzyme Inhibitors Enzyme Induction Ethinyl Estradiol - pharmacology Female In Vitro Techniques Liver - enzymology Male Microsomes, Liver - enzymology Norethindrone - pharmacology Population Porphyrins - metabolism Rats Time Factors
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