Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research
Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new mechanistic pathways which can lead to efficacious drugs or new drug targets. However, there is currently limited genetics data from Africa. The Uganda Genome...
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| Veröffentlicht in: | Molecular psychiatry 2025-01, Vol.30 (1), p.122-130 |
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| creator | Kalungi, Allan Kinyanda, Eugene Akena, Dickens Howard Gelaye, Bizu Ssembajjwe, Wilber Mpango, Richard Steven Ongaria, Terry Mugisha, Joseph Makanga, Ronald Kakande, Ayoub Kimono, Beatrice Amanyire, Philip Kirumira, Fred Lewis, Cathryn M. McIntosh, Andrew M. Kuchenbaecker, Karoline Nyirenda, Moffat Kaleebu, Pontiano Fatumo, Segun |
| description | Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new mechanistic pathways which can lead to efficacious drugs or new drug targets. However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa. We aimed at determining the prevalence and correlates of major depressive disorder (MDD), suicidality, post-traumatic stress disorder (PTSD), alcohol abuse, generalised anxiety disorder (GAD) and probable attention-deficit hyperactivity disorder (ADHD) among participants of the Uganda Genome Resource. Standardised tools assessed for each mental disorder. Prevalence of each disorder was calculated with 95% confidence intervals. Multivariate logistic regression models evaluated the association between each mental disorder and associated demographic and clinical factors. Among 985 participants, prevalence of the disorders were: current MDD 19.3%, life-time MDD 23.3%, suicidality 10.6%, PTSD 3.1%, alcohol abuse 5.7%, GAD 12.9% and probable ADHD 9.2%. This is the first study to determine the prevalence of probable ADHD among adult Ugandans from a general population. We found significant association between sex and alcohol abuse (adjusted odds ratio [AOR] = 0.26 [0.14,0.45], p |
| doi_str_mv | 10.1038/s41380-024-02665-8 |
| format | Article |
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However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa. We aimed at determining the prevalence and correlates of major depressive disorder (MDD), suicidality, post-traumatic stress disorder (PTSD), alcohol abuse, generalised anxiety disorder (GAD) and probable attention-deficit hyperactivity disorder (ADHD) among participants of the Uganda Genome Resource. Standardised tools assessed for each mental disorder. Prevalence of each disorder was calculated with 95% confidence intervals. Multivariate logistic regression models evaluated the association between each mental disorder and associated demographic and clinical factors. Among 985 participants, prevalence of the disorders were: current MDD 19.3%, life-time MDD 23.3%, suicidality 10.6%, PTSD 3.1%, alcohol abuse 5.7%, GAD 12.9% and probable ADHD 9.2%. This is the first study to determine the prevalence of probable ADHD among adult Ugandans from a general population. We found significant association between sex and alcohol abuse (adjusted odds ratio [AOR] = 0.26 [0.14,0.45], p < 0.001) and GAD (AOR = 1.78 [1.09,2.49], p = 0.019) respectively. We also found significant association between body mass index and suicidality (AOR = 0.85 [0.73,0.99], p = 0.041), alcohol abuse (AOR = 0.86 [0.78,0.94], p = 0.003) and GAD (AOR = 0.93 [0.87,0.98], p = 0.008) respectively. We also found a significant association between high blood pressure and life-time MDD (AOR = 2.87 [1.08,7.66], p = 0.035) and probable ADHD (AOR = 1.99 [1.00,3.97], p = 0.050) respectively. We also found a statistically significant association between tobacco smoking and alcohol abuse (AOR = 3.2 [1.56,6.67], p = 0.002). We also found ever been married to be a risk factor for probable ADHD (AOR = 2.12 [0.88,5.14], p = 0.049). The Uganda Genome Resource presents opportunity for psychiatric genetics research among underrepresented people from Africa.</description><identifier>ISSN: 1359-4184</identifier><identifier>ISSN: 1476-5578</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-024-02665-8</identifier><identifier>PMID: 39003415</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/43 ; 631/208 ; 692/699/476 ; 692/699/476/1311 ; Adolescent ; Adult ; Alcohol abuse ; Alcoholism - epidemiology ; Alcoholism - genetics ; Anxiety disorders ; Anxiety Disorders - epidemiology ; Anxiety Disorders - genetics ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit hyperactivity disorder ; Behavioral Sciences ; Biological Psychology ; Blood pressure ; Body mass index ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - genetics ; Drug abuse ; Female ; Generalized anxiety disorder ; Genomes ; Humans ; Hypertension ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Mental disorders ; Mental Disorders - epidemiology ; Mental Disorders - genetics ; Middle Aged ; Neurosciences ; Pharmacotherapy ; Population studies ; Post traumatic stress disorder ; Prevalence ; Psychiatry ; Regression analysis ; Risk factors ; Sex ratio ; Statistical analysis ; Stress Disorders, Post-Traumatic - epidemiology ; Stress Disorders, Post-Traumatic - genetics ; Suicidal ideation ; Therapeutic targets ; Tobacco smoking ; Uganda - epidemiology ; Young Adult</subject><ispartof>Molecular psychiatry, 2025-01, Vol.30 (1), p.122-130</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>Copyright Nature Publishing Group Jan 2025</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-13241b00e2636c9511f4d406dc45102c12fe2f47234366a61c6dff482005ba383</cites><orcidid>0000-0002-8249-8476 ; 0000-0002-0198-4588 ; 0000-0002-2890-0145 ; 0000-0001-9726-603X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-024-02665-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-024-02665-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39003415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalungi, Allan</creatorcontrib><creatorcontrib>Kinyanda, Eugene</creatorcontrib><creatorcontrib>Akena, Dickens Howard</creatorcontrib><creatorcontrib>Gelaye, Bizu</creatorcontrib><creatorcontrib>Ssembajjwe, Wilber</creatorcontrib><creatorcontrib>Mpango, Richard Steven</creatorcontrib><creatorcontrib>Ongaria, Terry</creatorcontrib><creatorcontrib>Mugisha, Joseph</creatorcontrib><creatorcontrib>Makanga, Ronald</creatorcontrib><creatorcontrib>Kakande, Ayoub</creatorcontrib><creatorcontrib>Kimono, Beatrice</creatorcontrib><creatorcontrib>Amanyire, Philip</creatorcontrib><creatorcontrib>Kirumira, Fred</creatorcontrib><creatorcontrib>Lewis, Cathryn M.</creatorcontrib><creatorcontrib>McIntosh, Andrew M.</creatorcontrib><creatorcontrib>Kuchenbaecker, Karoline</creatorcontrib><creatorcontrib>Nyirenda, Moffat</creatorcontrib><creatorcontrib>Kaleebu, Pontiano</creatorcontrib><creatorcontrib>Fatumo, Segun</creatorcontrib><title>Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new mechanistic pathways which can lead to efficacious drugs or new drug targets. However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa. We aimed at determining the prevalence and correlates of major depressive disorder (MDD), suicidality, post-traumatic stress disorder (PTSD), alcohol abuse, generalised anxiety disorder (GAD) and probable attention-deficit hyperactivity disorder (ADHD) among participants of the Uganda Genome Resource. Standardised tools assessed for each mental disorder. Prevalence of each disorder was calculated with 95% confidence intervals. Multivariate logistic regression models evaluated the association between each mental disorder and associated demographic and clinical factors. Among 985 participants, prevalence of the disorders were: current MDD 19.3%, life-time MDD 23.3%, suicidality 10.6%, PTSD 3.1%, alcohol abuse 5.7%, GAD 12.9% and probable ADHD 9.2%. This is the first study to determine the prevalence of probable ADHD among adult Ugandans from a general population. We found significant association between sex and alcohol abuse (adjusted odds ratio [AOR] = 0.26 [0.14,0.45], p < 0.001) and GAD (AOR = 1.78 [1.09,2.49], p = 0.019) respectively. We also found significant association between body mass index and suicidality (AOR = 0.85 [0.73,0.99], p = 0.041), alcohol abuse (AOR = 0.86 [0.78,0.94], p = 0.003) and GAD (AOR = 0.93 [0.87,0.98], p = 0.008) respectively. We also found a significant association between high blood pressure and life-time MDD (AOR = 2.87 [1.08,7.66], p = 0.035) and probable ADHD (AOR = 1.99 [1.00,3.97], p = 0.050) respectively. We also found a statistically significant association between tobacco smoking and alcohol abuse (AOR = 3.2 [1.56,6.67], p = 0.002). We also found ever been married to be a risk factor for probable ADHD (AOR = 2.12 [0.88,5.14], p = 0.049). The Uganda Genome Resource presents opportunity for psychiatric genetics research among underrepresented people from Africa.</description><subject>45</subject><subject>45/43</subject><subject>631/208</subject><subject>692/699/476</subject><subject>692/699/476/1311</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Alcohol abuse</subject><subject>Alcoholism - epidemiology</subject><subject>Alcoholism - genetics</subject><subject>Anxiety disorders</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Generalized anxiety disorder</subject><subject>Genomes</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - genetics</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Pharmacotherapy</subject><subject>Population studies</subject><subject>Post traumatic stress disorder</subject><subject>Prevalence</subject><subject>Psychiatry</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Sex ratio</subject><subject>Statistical analysis</subject><subject>Stress Disorders, Post-Traumatic - epidemiology</subject><subject>Stress Disorders, Post-Traumatic - genetics</subject><subject>Suicidal ideation</subject><subject>Therapeutic targets</subject><subject>Tobacco smoking</subject><subject>Uganda - 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However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa. We aimed at determining the prevalence and correlates of major depressive disorder (MDD), suicidality, post-traumatic stress disorder (PTSD), alcohol abuse, generalised anxiety disorder (GAD) and probable attention-deficit hyperactivity disorder (ADHD) among participants of the Uganda Genome Resource. Standardised tools assessed for each mental disorder. Prevalence of each disorder was calculated with 95% confidence intervals. Multivariate logistic regression models evaluated the association between each mental disorder and associated demographic and clinical factors. Among 985 participants, prevalence of the disorders were: current MDD 19.3%, life-time MDD 23.3%, suicidality 10.6%, PTSD 3.1%, alcohol abuse 5.7%, GAD 12.9% and probable ADHD 9.2%. This is the first study to determine the prevalence of probable ADHD among adult Ugandans from a general population. We found significant association between sex and alcohol abuse (adjusted odds ratio [AOR] = 0.26 [0.14,0.45], p < 0.001) and GAD (AOR = 1.78 [1.09,2.49], p = 0.019) respectively. We also found significant association between body mass index and suicidality (AOR = 0.85 [0.73,0.99], p = 0.041), alcohol abuse (AOR = 0.86 [0.78,0.94], p = 0.003) and GAD (AOR = 0.93 [0.87,0.98], p = 0.008) respectively. We also found a significant association between high blood pressure and life-time MDD (AOR = 2.87 [1.08,7.66], p = 0.035) and probable ADHD (AOR = 1.99 [1.00,3.97], p = 0.050) respectively. We also found a statistically significant association between tobacco smoking and alcohol abuse (AOR = 3.2 [1.56,6.67], p = 0.002). We also found ever been married to be a risk factor for probable ADHD (AOR = 2.12 [0.88,5.14], p = 0.049). The Uganda Genome Resource presents opportunity for psychiatric genetics research among underrepresented people from Africa.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39003415</pmid><doi>10.1038/s41380-024-02665-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8249-8476</orcidid><orcidid>https://orcid.org/0000-0002-0198-4588</orcidid><orcidid>https://orcid.org/0000-0002-2890-0145</orcidid><orcidid>https://orcid.org/0000-0001-9726-603X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2025-01, Vol.30 (1), p.122-130 |
| issn | 1359-4184 1476-5578 1476-5578 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11649557 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 45 45/43 631/208 692/699/476 692/699/476/1311 Adolescent Adult Alcohol abuse Alcoholism - epidemiology Alcoholism - genetics Anxiety disorders Anxiety Disorders - epidemiology Anxiety Disorders - genetics Attention Deficit Disorder with Hyperactivity - epidemiology Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Behavioral Sciences Biological Psychology Blood pressure Body mass index Depressive Disorder, Major - epidemiology Depressive Disorder, Major - genetics Drug abuse Female Generalized anxiety disorder Genomes Humans Hypertension Male Medicine Medicine & Public Health Mental depression Mental disorders Mental Disorders - epidemiology Mental Disorders - genetics Middle Aged Neurosciences Pharmacotherapy Population studies Post traumatic stress disorder Prevalence Psychiatry Regression analysis Risk factors Sex ratio Statistical analysis Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - genetics Suicidal ideation Therapeutic targets Tobacco smoking Uganda - epidemiology Young Adult |
| title | Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research |
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