Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms

A series of 2,4‐dichloro‐5‐{[4‐(phenylsulfonyl)piperazin‐1‐yl]carbonyl}benzenesulfonamides were designed and synthesized through amidation of Lasamide 1 with substituted piperazines. The newly obtained compounds demonstrated remarkable inhibition potency and selectivity for the human (h) expressed C...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2024-12, Vol.19 (24), p.e202400601-n/a
Hauptverfasser:	Kilbile, Jaydeo T., Sapkal, Suryakant B., Renzi, Gioele, D'Agostino, Ilaria, Boudjelal, Mohamed, Tamboli, Yasinalli, Cutarella, Luigi, Mori, Mattia, Sgambellone, Silvia, Villano, Serafina, Marri, Silvia, Lucarini, Laura, Carradori, Simone, Carta, Fabrizio, Supuran, Claudiu T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbonic Anhydrase Carbonic Anhydrase II - antagonists & inhibitors Carbonic Anhydrase II - metabolism Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrase Inhibitors - therapeutic use Carbonyl compounds Carbonyls Glaucoma Glaucoma - drug therapy Humans In vivo methods and tests Intraocular Pressure - drug effects IOP Lasamide Molecular Structure Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Pressure effects Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Sulfonamides - therapeutic use Sulfonylpiperazines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!