Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data
To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS ® green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventi...
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| Veröffentlicht in: | Lasers in medical science 2024-12, Vol.39 (1), p.293, Article 293 |
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| creator | Pillunat, Karin R. Kretz, Florian T. A. Koinzer, Stefan Müller, Philipp Pillunat, Lutz E. Klabe, Karsten |
| description | To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS
®
green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS
®
green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat – mITT –group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (
p
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| doi_str_mv | 10.1007/s10103-024-04252-3 |
| format | Article |
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®
green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS
®
green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat – mITT –group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (
p
< 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS
®
green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.</description><identifier>ISSN: 1435-604X</identifier><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-024-04252-3</identifier><identifier>PMID: 39674816</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adverse events ; Aged ; Complications ; Dentistry ; Effectiveness ; Eye ; Female ; Glaucoma ; Glaucoma, Open-Angle - surgery ; Humans ; Intraocular Pressure ; Laser Therapy - adverse effects ; Laser Therapy - instrumentation ; Laser Therapy - methods ; Lasers ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Optical Devices ; Optics ; Original ; Original Article ; Patients ; Photonics ; Quantum Optics ; Retrospective Studies ; Safety ; Trabeculectomy - instrumentation ; Trabeculectomy - methods ; Treatment Outcome</subject><ispartof>Lasers in medical science, 2024-12, Vol.39 (1), p.293, Article 293</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>Copyright Springer Nature B.V. Dec 2024</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2273-fa6d4dedf2a0d2778cda4864a311c1ac6fd9bbdb74dec5a9c45f65262c4979523</cites><orcidid>0000-0002-4400-6004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-024-04252-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-024-04252-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39674816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pillunat, Karin R.</creatorcontrib><creatorcontrib>Kretz, Florian T. A.</creatorcontrib><creatorcontrib>Koinzer, Stefan</creatorcontrib><creatorcontrib>Müller, Philipp</creatorcontrib><creatorcontrib>Pillunat, Lutz E.</creatorcontrib><creatorcontrib>Klabe, Karsten</creatorcontrib><title>Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS
®
green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS
®
green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat – mITT –group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (
p
< 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS
®
green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.</description><subject>Adverse events</subject><subject>Aged</subject><subject>Complications</subject><subject>Dentistry</subject><subject>Effectiveness</subject><subject>Eye</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - surgery</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Laser Therapy - adverse effects</subject><subject>Laser Therapy - instrumentation</subject><subject>Laser Therapy - methods</subject><subject>Lasers</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Photonics</subject><subject>Quantum Optics</subject><subject>Retrospective Studies</subject><subject>Safety</subject><subject>Trabeculectomy - instrumentation</subject><subject>Trabeculectomy - methods</subject><subject>Treatment Outcome</subject><issn>1435-604X</issn><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EoqXwAhyQJS5cUvwvdsIFVVVpK63EoRRxsxx7vM0qay92UmnfhifgIfpkuGRb2h7wZWzNbz7PzIfQW0oOKSHqY6aEEl4RJioiWM0q_gztU8HrShLx4_mD-x56lfOKEKok5S_RHm-lEg2V-2h14j3Ysb-GADljExzOxsO4xdHj7-cXl4uji5vfeJkAAs4wzCweTIaEx2Q6sNMQN-U9bj9hym5-rWMYrzJOMKaYNzvemdG8Ri-8GTK82cUDdPnl5NvxWbX4enp-fLSoLGOKV95IJxw4zwxxTKnGOiMaKQyn1FJjpXdt17lOFcjWprWi9rJmklnRqrZm_AB9nnU3U7cGZyGUPge9Sf3apK2OptePM6G_0st4rSmVQjImisKHnUKKPyfIo1732cIwmABxyppTIZWqm7ot6Psn6CpOKZT5bqlyiGpkodhM2bKTnMDfd0OJvvVSz17q4qX-66XmpejdwznuS-7MKwCfgVxSYQnp39__kf0DIiatgA</recordid><startdate>20241215</startdate><enddate>20241215</enddate><creator>Pillunat, Karin R.</creator><creator>Kretz, Florian T. A.</creator><creator>Koinzer, Stefan</creator><creator>Müller, Philipp</creator><creator>Pillunat, Lutz E.</creator><creator>Klabe, Karsten</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>H8D</scope><scope>K9.</scope><scope>L7M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4400-6004</orcidid></search><sort><creationdate>20241215</creationdate><title>Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data</title><author>Pillunat, Karin R. ; Kretz, Florian T. A. ; Koinzer, Stefan ; Müller, Philipp ; Pillunat, Lutz E. ; Klabe, Karsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2273-fa6d4dedf2a0d2778cda4864a311c1ac6fd9bbdb74dec5a9c45f65262c4979523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adverse events</topic><topic>Aged</topic><topic>Complications</topic><topic>Dentistry</topic><topic>Effectiveness</topic><topic>Eye</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - surgery</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Laser Therapy - adverse effects</topic><topic>Laser Therapy - instrumentation</topic><topic>Laser Therapy - methods</topic><topic>Lasers</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Photonics</topic><topic>Quantum Optics</topic><topic>Retrospective Studies</topic><topic>Safety</topic><topic>Trabeculectomy - instrumentation</topic><topic>Trabeculectomy - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pillunat, Karin R.</creatorcontrib><creatorcontrib>Kretz, Florian T. A.</creatorcontrib><creatorcontrib>Koinzer, Stefan</creatorcontrib><creatorcontrib>Müller, Philipp</creatorcontrib><creatorcontrib>Pillunat, Lutz E.</creatorcontrib><creatorcontrib>Klabe, Karsten</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pillunat, Karin R.</au><au>Kretz, Florian T. A.</au><au>Koinzer, Stefan</au><au>Müller, Philipp</au><au>Pillunat, Lutz E.</au><au>Klabe, Karsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2024-12-15</date><risdate>2024</risdate><volume>39</volume><issue>1</issue><spage>293</spage><pages>293-</pages><artnum>293</artnum><issn>1435-604X</issn><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS
®
green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS
®
green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat – mITT –group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (
p
< 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS
®
green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.</abstract><cop>London</cop><pub>Springer London</pub><pmid>39674816</pmid><doi>10.1007/s10103-024-04252-3</doi><orcidid>https://orcid.org/0000-0002-4400-6004</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adverse events Aged Complications Dentistry Effectiveness Eye Female Glaucoma Glaucoma, Open-Angle - surgery Humans Intraocular Pressure Laser Therapy - adverse effects Laser Therapy - instrumentation Laser Therapy - methods Lasers Male Medicine Medicine & Public Health Middle Aged Optical Devices Optics Original Original Article Patients Photonics Quantum Optics Retrospective Studies Safety Trabeculectomy - instrumentation Trabeculectomy - methods Treatment Outcome |
| title | Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data |
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