Intraoperative Use of Sodium Bicarbonate Ringer's Solution Instead of Sodium Lactate Ringer's Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study

To investigate the effect of sodium bicarbonate Ringer's solution (BRS) on the degradation of endothelial glycocalyx components in patients undergoing cardiopulmonary bypass (CPB) during cardiac surgery, and to evaluate its impact on endothelial glycocalyx preservation and postoperative recover...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2024, Vol.18, p.5881-5893
Hauptverfasser:	Shi, Yujie, Shi, Yuan, Tao, Yujia, Xu, Bingyan, Wang, Xiaoming, Xie, Yanhu, Zhang, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia Anticoagulants Blood gas analysis Bypass Cardiac Surgical Procedures - adverse effects Cardiopulmonary Bypass - adverse effects Clinical outcomes Cohort Studies Creatinine Degradation Female Gelatinase B General anesthesia Glycocalyx - drug effects Glycocalyx - metabolism Heart Heart surgery Heart valves Hemodynamics Humans Inflammation Interleukin 6 Interleukin 8 Kidneys Lactic acid Male Matrix metalloproteinase Matrix metalloproteinases Mechanical ventilation Mental disorders Metal concentrations Metalloproteinase Middle Aged Original Research Oxidative stress Patients Prospective Studies Recovery Ringer's Lactate - administration & dosage Ringer's Lactate - pharmacology Ringer's Solution - administration & dosage Ringer's Solution - pharmacology Sodium Sodium bicarbonate Sodium Bicarbonate - administration & dosage Sodium Bicarbonate - pharmacology Sodium lactate Stromelysin 1 Surgery Syndecan Transforming growth factor-b Tumor necrosis factor-TNF Tumor necrosis factor-α Weaning
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