A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neutralizing coronavirus mAbs that are sufficiently potent for...

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Veröffentlicht in:	Cell 2024-12, Vol.187 (25), p.7196-7213.e26
Hauptverfasser:	Rosen, Laura E., Tortorici, M. Alejandra, De Marco, Anna, Pinto, Dora, Foreman, William B., Taylor, Ashley L., Park, Young-Jun, Bohan, Dana, Rietz, Tyson, Errico, John M., Hauser, Kevin, Dang, Ha V., Chartron, Justin W., Giurdanella, Martina, Cusumano, Giuseppe, Saliba, Christian, Zatta, Fabrizia, Sprouse, Kaitlin R., Addetia, Amin, Zepeda, Samantha K., Brown, Jack, Lee, Jimin, Dellota, Exequiel, Rajesh, Anushka, Noack, Julia, Tao, Qiqing, DaCosta, Yvonne, Tsu, Brian, Acosta, Rima, Subramanian, Sambhavi, de Melo, Guilherme Dias, Kergoat, Lauriane, Zhang, Ivy, Liu, Zhuoming, Guarino, Barbara, Schmid, Michael A., Schnell, Gretja, Miller, Jessica L., Lempp, Florian A., Czudnochowski, Nadine, Cameroni, Elisabetta, Whelan, Sean P.J., Bourhy, Hervé, Purcell, Lisa A., Benigni, Fabio, di Iulio, Julia, Pizzuto, Matteo Samuele, Lanzavecchia, Antonio, Telenti, Amalio, Snell, Gyorgy, Corti, Davide, Veesler, David, Starr, Tyler N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 - chemistry Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - immunology broadly neutralizing antibody Chiroptera - immunology Chiroptera - virology COVID-19 - immunology COVID-19 - virology Cross Reactions - immunology Epitopes - chemistry Epitopes - immunology Humans Life Sciences monoclonal antibody sarbecovirus SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism viral antibody escape
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