Attenuated kidney oxidative metabolism in young adults with type 1 diabetes
BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp...
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| Veröffentlicht in: | The Journal of clinical investigation 2024-12, Vol.134 (24) |
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| creator | Choi, Ye Ji Richard, Gabriel Zhang, Guanshi Hodgin, Jeffrey B Demeke, Dawit S Yang, Yingbao Schaub, Jennifer A Tamayo, Ian M Gurung, Bhupendra K Naik, Abhijit S Nair, Viji Birznieks, Carissa MacDonald, Alexis Narongkiatikhun, Phoom Gross, Susan Driscoll, Lynette Flynn, Maureen Tommerdahl, Kalie Nadeau, Kristen J Shah, Viral N Vigers, Tim Snell-Bergeon, Janet K Kendrick, Jessica van Raalte, Daniel H Li, Lu-Ping Prasad, Pottumarthi Ladd, Patricia Chin, Bennett B Cherney, David Z McCown, Phillip J Alakwaa, Fadhl Otto, Edgar A Brosius, Frank C Saulnier, Pierre Jean Puelles, Victor G Goodrich, Jesse A Street, Kelly Venkatachalam, Manjeri A Ruiz, Aaron de Boer, Ian H Nelson, Robert G Pyle, Laura Blondin, Denis P Sharma, Kumar Kretzler, Matthias Bjornstad, Petter |
| description | BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTSParticipants with T1D had significantly higher glomerular basement membrane (GBM) thickness compared with HCs. T1D participants exhibited lower insulin sensitivity and cortical oxidative metabolism, correlating with higher insulin sensitivity. Proximal tubular transcripts of TCA cycle and oxidative phosphorylation enzymes were lower in T1D. Spatial metabolomics showed reductions in tubular TCA cycle intermediates, indicating mitochondrial dysfunction. The Slingshot algorithm identified a lineage of proximal tubular cells progressing from stable to adaptive/maladaptive subtypes, using pseudotime trajectory analysis, which computationally orders cells along a continuum of states. This analysis revealed distinct distribution patterns between T1D and HCs, with attenuated oxidative metabolism in T1D attributed to a greater proportion of adaptive/maladaptive subtypes with low expression of TCA cycle and oxidative phosphorylation transcripts. Pseudotime progression associated with higher HbA1c, BMI, and GBM, and lower insulin sensitivity and cortical oxidative metabolism.CONCLUSIONThese early structural and metabolic changes in T1D kidneys may precede clinical DKD.TRIAL REGISTRATIONClinicalTrials.gov NCT04074668.FUNDINGUniversity of Michigan O'Brien Kidney Translational Core Center grant (P30 DK081943); CROCODILE studies by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (P30 DK116073), Juvenile Diabetes Research Foundation (JDRF) (2-SRA-2019-845-S-B), Boettcher Foundation, Intramural Research Program at NIDDK and Centers for Disease Control and Prevention (CKD Initiative) under Inter-Agency Agreement #21FED2100157DPG. |
| doi_str_mv | 10.1172/JCI183984 |
| format | Article |
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T1D participants exhibited lower insulin sensitivity and cortical oxidative metabolism, correlating with higher insulin sensitivity. Proximal tubular transcripts of TCA cycle and oxidative phosphorylation enzymes were lower in T1D. Spatial metabolomics showed reductions in tubular TCA cycle intermediates, indicating mitochondrial dysfunction. The Slingshot algorithm identified a lineage of proximal tubular cells progressing from stable to adaptive/maladaptive subtypes, using pseudotime trajectory analysis, which computationally orders cells along a continuum of states. This analysis revealed distinct distribution patterns between T1D and HCs, with attenuated oxidative metabolism in T1D attributed to a greater proportion of adaptive/maladaptive subtypes with low expression of TCA cycle and oxidative phosphorylation transcripts. Pseudotime progression associated with higher HbA1c, BMI, and GBM, and lower insulin sensitivity and cortical oxidative metabolism.CONCLUSIONThese early structural and metabolic changes in T1D kidneys may precede clinical DKD.TRIAL REGISTRATIONClinicalTrials.gov NCT04074668.FUNDINGUniversity of Michigan O'Brien Kidney Translational Core Center grant (P30 DK081943); CROCODILE studies by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (P30 DK116073), Juvenile Diabetes Research Foundation (JDRF) (2-SRA-2019-845-S-B), Boettcher Foundation, Intramural Research Program at NIDDK and Centers for Disease Control and Prevention (CKD Initiative) under Inter-Agency Agreement #21FED2100157DPG.</description><identifier>ISSN: 1558-8238</identifier><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI183984</identifier><identifier>PMID: 39436695</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Adult ; Care and treatment ; Citric Acid Cycle ; Clinical Medicine ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - pathology ; Diabetic nephropathies ; Diabetic Nephropathies - genetics ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diagnosis ; Female ; Humans ; Insulin Resistance ; Kidney - metabolism ; Kidney - pathology ; Male ; Metabolomics ; Oxidation-Reduction ; Oxidative stress ; Type 1 diabetes ; Young Adult</subject><ispartof>The Journal of clinical investigation, 2024-12, Vol.134 (24)</ispartof><rights>COPYRIGHT 2024 American Society for Clinical Investigation</rights><rights>2024 Choi et al. 2024 Choi et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c470t-b2d5d1791be438426a5bfa9f215470fa84ce0fc644256e4a934e612def2514183</cites><orcidid>0000-0003-1862-4252 ; 0000-0001-6805-0985 ; 0000-0002-3827-7107 ; 0000-0002-7550-8525 ; 0000-0002-7735-5462 ; 0000-0003-1602-9425 ; 0000-0003-4064-0582 ; 0000-0002-2387-9973 ; 0000-0002-4244-8335 ; 0000-0001-6557-4521 ; 0000-0003-1571-7592 ; 0000-0001-7307-3786 ; 0000-0001-7087-8570 ; 0000-0002-8012-1931 ; 0000-0003-0534-3048</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645151/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645151/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39436695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Ye Ji</creatorcontrib><creatorcontrib>Richard, Gabriel</creatorcontrib><creatorcontrib>Zhang, Guanshi</creatorcontrib><creatorcontrib>Hodgin, Jeffrey B</creatorcontrib><creatorcontrib>Demeke, Dawit S</creatorcontrib><creatorcontrib>Yang, Yingbao</creatorcontrib><creatorcontrib>Schaub, Jennifer A</creatorcontrib><creatorcontrib>Tamayo, Ian M</creatorcontrib><creatorcontrib>Gurung, Bhupendra K</creatorcontrib><creatorcontrib>Naik, Abhijit S</creatorcontrib><creatorcontrib>Nair, Viji</creatorcontrib><creatorcontrib>Birznieks, Carissa</creatorcontrib><creatorcontrib>MacDonald, Alexis</creatorcontrib><creatorcontrib>Narongkiatikhun, Phoom</creatorcontrib><creatorcontrib>Gross, Susan</creatorcontrib><creatorcontrib>Driscoll, Lynette</creatorcontrib><creatorcontrib>Flynn, Maureen</creatorcontrib><creatorcontrib>Tommerdahl, Kalie</creatorcontrib><creatorcontrib>Nadeau, Kristen J</creatorcontrib><creatorcontrib>Shah, Viral N</creatorcontrib><creatorcontrib>Vigers, Tim</creatorcontrib><creatorcontrib>Snell-Bergeon, Janet K</creatorcontrib><creatorcontrib>Kendrick, Jessica</creatorcontrib><creatorcontrib>van Raalte, Daniel H</creatorcontrib><creatorcontrib>Li, Lu-Ping</creatorcontrib><creatorcontrib>Prasad, Pottumarthi</creatorcontrib><creatorcontrib>Ladd, Patricia</creatorcontrib><creatorcontrib>Chin, Bennett B</creatorcontrib><creatorcontrib>Cherney, David Z</creatorcontrib><creatorcontrib>McCown, Phillip J</creatorcontrib><creatorcontrib>Alakwaa, Fadhl</creatorcontrib><creatorcontrib>Otto, Edgar A</creatorcontrib><creatorcontrib>Brosius, Frank C</creatorcontrib><creatorcontrib>Saulnier, Pierre Jean</creatorcontrib><creatorcontrib>Puelles, Victor G</creatorcontrib><creatorcontrib>Goodrich, Jesse A</creatorcontrib><creatorcontrib>Street, Kelly</creatorcontrib><creatorcontrib>Venkatachalam, Manjeri A</creatorcontrib><creatorcontrib>Ruiz, Aaron</creatorcontrib><creatorcontrib>de Boer, Ian H</creatorcontrib><creatorcontrib>Nelson, Robert G</creatorcontrib><creatorcontrib>Pyle, Laura</creatorcontrib><creatorcontrib>Blondin, Denis P</creatorcontrib><creatorcontrib>Sharma, Kumar</creatorcontrib><creatorcontrib>Kretzler, Matthias</creatorcontrib><creatorcontrib>Bjornstad, Petter</creatorcontrib><title>Attenuated kidney oxidative metabolism in young adults with type 1 diabetes</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTSParticipants with T1D had significantly higher glomerular basement membrane (GBM) thickness compared with HCs. T1D participants exhibited lower insulin sensitivity and cortical oxidative metabolism, correlating with higher insulin sensitivity. Proximal tubular transcripts of TCA cycle and oxidative phosphorylation enzymes were lower in T1D. Spatial metabolomics showed reductions in tubular TCA cycle intermediates, indicating mitochondrial dysfunction. The Slingshot algorithm identified a lineage of proximal tubular cells progressing from stable to adaptive/maladaptive subtypes, using pseudotime trajectory analysis, which computationally orders cells along a continuum of states. This analysis revealed distinct distribution patterns between T1D and HCs, with attenuated oxidative metabolism in T1D attributed to a greater proportion of adaptive/maladaptive subtypes with low expression of TCA cycle and oxidative phosphorylation transcripts. Pseudotime progression associated with higher HbA1c, BMI, and GBM, and lower insulin sensitivity and cortical oxidative metabolism.CONCLUSIONThese early structural and metabolic changes in T1D kidneys may precede clinical DKD.TRIAL REGISTRATIONClinicalTrials.gov NCT04074668.FUNDINGUniversity of Michigan O'Brien Kidney Translational Core Center grant (P30 DK081943); CROCODILE studies by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (P30 DK116073), Juvenile Diabetes Research Foundation (JDRF) (2-SRA-2019-845-S-B), Boettcher Foundation, Intramural Research Program at NIDDK and Centers for Disease Control and Prevention (CKD Initiative) under Inter-Agency Agreement #21FED2100157DPG.</description><subject>Adult</subject><subject>Care and treatment</subject><subject>Citric Acid Cycle</subject><subject>Clinical Medicine</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Diabetic nephropathies</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Metabolomics</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Type 1 diabetes</subject><subject>Young Adult</subject><issn>1558-8238</issn><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktr3DAURk1paR7ton-gCAqlWTjxlSU_VmEY2nTaQKCvrZCtK49aW5pacpL599WQdJiBWQQtJHTPPULSlyRvIDsHKOnFl_kCqryu2LPkGDiv0orm1fOd9VFy4v3vLAPGOHuZHOU1y4ui5sfJ11kIaCcZUJE_RllcE3dvlAzmFsmAQTauN34gxpK1m2xHpJr64MmdCUsS1iskQJSRDQb0r5IXWvYeXz_Op8nPTx9_zD-n1zdXi_nsOm1ZmYW0oYorKGtokOUVo4XkjZa1psBjXcuKtZjptmCM8gKZrHOGBVCFmnJg8aKnyeWDdzU1A6oWbRhlL1ajGeS4Fk4asV-xZik6dysACsaBQzR8eDSM7u-EPojB-Bb7Xlp0kxc5QF1SKDmP6LsHtJM9CmO1i8p2g4tZRWlZ1VBshOkBqkOL8XxnUZu4vcefH-DjUDiY9mDD2V5DZALeh05O3ovF929PZ29-7bPvd9glyj4sveunYJz1B6Xt6LwfUW_fGzKxSaHYpjCyb3c_aEv-j13-D2vx00M</recordid><startdate>20241215</startdate><enddate>20241215</enddate><creator>Choi, Ye Ji</creator><creator>Richard, Gabriel</creator><creator>Zhang, Guanshi</creator><creator>Hodgin, Jeffrey B</creator><creator>Demeke, Dawit 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kidney oxidative metabolism in young adults with type 1 diabetes</title><author>Choi, Ye Ji ; Richard, Gabriel ; Zhang, Guanshi ; Hodgin, Jeffrey B ; Demeke, Dawit S ; Yang, Yingbao ; Schaub, Jennifer A ; Tamayo, Ian M ; Gurung, Bhupendra K ; Naik, Abhijit S ; Nair, Viji ; Birznieks, Carissa ; MacDonald, Alexis ; Narongkiatikhun, Phoom ; Gross, Susan ; Driscoll, Lynette ; Flynn, Maureen ; Tommerdahl, Kalie ; Nadeau, Kristen J ; Shah, Viral N ; Vigers, Tim ; Snell-Bergeon, Janet K ; Kendrick, Jessica ; van Raalte, Daniel H ; Li, Lu-Ping ; Prasad, Pottumarthi ; Ladd, Patricia ; Chin, Bennett B ; Cherney, David Z ; McCown, Phillip J ; Alakwaa, Fadhl ; Otto, Edgar A ; Brosius, Frank C ; Saulnier, Pierre Jean ; Puelles, Victor G ; Goodrich, Jesse A ; Street, Kelly ; Venkatachalam, Manjeri A ; Ruiz, Aaron ; de Boer, Ian H ; Nelson, Robert G ; Pyle, Laura ; Blondin, Denis P ; Sharma, Kumar ; Kretzler, Matthias ; Bjornstad, 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Susan</creatorcontrib><creatorcontrib>Driscoll, Lynette</creatorcontrib><creatorcontrib>Flynn, Maureen</creatorcontrib><creatorcontrib>Tommerdahl, Kalie</creatorcontrib><creatorcontrib>Nadeau, Kristen J</creatorcontrib><creatorcontrib>Shah, Viral N</creatorcontrib><creatorcontrib>Vigers, Tim</creatorcontrib><creatorcontrib>Snell-Bergeon, Janet K</creatorcontrib><creatorcontrib>Kendrick, Jessica</creatorcontrib><creatorcontrib>van Raalte, Daniel H</creatorcontrib><creatorcontrib>Li, Lu-Ping</creatorcontrib><creatorcontrib>Prasad, Pottumarthi</creatorcontrib><creatorcontrib>Ladd, Patricia</creatorcontrib><creatorcontrib>Chin, Bennett B</creatorcontrib><creatorcontrib>Cherney, David Z</creatorcontrib><creatorcontrib>McCown, Phillip J</creatorcontrib><creatorcontrib>Alakwaa, Fadhl</creatorcontrib><creatorcontrib>Otto, Edgar A</creatorcontrib><creatorcontrib>Brosius, Frank C</creatorcontrib><creatorcontrib>Saulnier, Pierre Jean</creatorcontrib><creatorcontrib>Puelles, Victor G</creatorcontrib><creatorcontrib>Goodrich, Jesse A</creatorcontrib><creatorcontrib>Street, Kelly</creatorcontrib><creatorcontrib>Venkatachalam, Manjeri A</creatorcontrib><creatorcontrib>Ruiz, Aaron</creatorcontrib><creatorcontrib>de Boer, Ian H</creatorcontrib><creatorcontrib>Nelson, Robert G</creatorcontrib><creatorcontrib>Pyle, Laura</creatorcontrib><creatorcontrib>Blondin, Denis P</creatorcontrib><creatorcontrib>Sharma, Kumar</creatorcontrib><creatorcontrib>Kretzler, Matthias</creatorcontrib><creatorcontrib>Bjornstad, Petter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Ye Ji</au><au>Richard, Gabriel</au><au>Zhang, Guanshi</au><au>Hodgin, Jeffrey B</au><au>Demeke, Dawit S</au><au>Yang, Yingbao</au><au>Schaub, Jennifer A</au><au>Tamayo, Ian M</au><au>Gurung, Bhupendra K</au><au>Naik, Abhijit S</au><au>Nair, Viji</au><au>Birznieks, Carissa</au><au>MacDonald, Alexis</au><au>Narongkiatikhun, Phoom</au><au>Gross, Susan</au><au>Driscoll, Lynette</au><au>Flynn, Maureen</au><au>Tommerdahl, Kalie</au><au>Nadeau, Kristen J</au><au>Shah, Viral N</au><au>Vigers, Tim</au><au>Snell-Bergeon, Janet K</au><au>Kendrick, Jessica</au><au>van Raalte, Daniel H</au><au>Li, Lu-Ping</au><au>Prasad, Pottumarthi</au><au>Ladd, Patricia</au><au>Chin, Bennett B</au><au>Cherney, David Z</au><au>McCown, Phillip J</au><au>Alakwaa, Fadhl</au><au>Otto, Edgar A</au><au>Brosius, Frank C</au><au>Saulnier, Pierre Jean</au><au>Puelles, Victor G</au><au>Goodrich, Jesse A</au><au>Street, Kelly</au><au>Venkatachalam, Manjeri A</au><au>Ruiz, Aaron</au><au>de Boer, Ian H</au><au>Nelson, Robert G</au><au>Pyle, Laura</au><au>Blondin, Denis P</au><au>Sharma, Kumar</au><au>Kretzler, Matthias</au><au>Bjornstad, Petter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuated kidney oxidative metabolism in young adults with type 1 diabetes</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>2024-12-15</date><risdate>2024</risdate><volume>134</volume><issue>24</issue><issn>1558-8238</issn><issn>0021-9738</issn><eissn>1558-8238</eissn><abstract>BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTSParticipants with T1D had significantly higher glomerular basement membrane (GBM) thickness compared with HCs. T1D participants exhibited lower insulin sensitivity and cortical oxidative metabolism, correlating with higher insulin sensitivity. Proximal tubular transcripts of TCA cycle and oxidative phosphorylation enzymes were lower in T1D. Spatial metabolomics showed reductions in tubular TCA cycle intermediates, indicating mitochondrial dysfunction. The Slingshot algorithm identified a lineage of proximal tubular cells progressing from stable to adaptive/maladaptive subtypes, using pseudotime trajectory analysis, which computationally orders cells along a continuum of states. This analysis revealed distinct distribution patterns between T1D and HCs, with attenuated oxidative metabolism in T1D attributed to a greater proportion of adaptive/maladaptive subtypes with low expression of TCA cycle and oxidative phosphorylation transcripts. Pseudotime progression associated with higher HbA1c, BMI, and GBM, and lower insulin sensitivity and cortical oxidative metabolism.CONCLUSIONThese early structural and metabolic changes in T1D kidneys may precede clinical DKD.TRIAL REGISTRATIONClinicalTrials.gov NCT04074668.FUNDINGUniversity of Michigan O'Brien Kidney Translational Core Center grant (P30 DK081943); CROCODILE studies by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (P30 DK116073), Juvenile Diabetes Research Foundation (JDRF) (2-SRA-2019-845-S-B), Boettcher Foundation, Intramural Research Program at NIDDK and Centers for Disease Control and Prevention (CKD Initiative) under Inter-Agency Agreement #21FED2100157DPG.</abstract><cop>United States</cop><pub>American Society for Clinical Investigation</pub><pmid>39436695</pmid><doi>10.1172/JCI183984</doi><orcidid>https://orcid.org/0000-0003-1862-4252</orcidid><orcidid>https://orcid.org/0000-0001-6805-0985</orcidid><orcidid>https://orcid.org/0000-0002-3827-7107</orcidid><orcidid>https://orcid.org/0000-0002-7550-8525</orcidid><orcidid>https://orcid.org/0000-0002-7735-5462</orcidid><orcidid>https://orcid.org/0000-0003-1602-9425</orcidid><orcidid>https://orcid.org/0000-0003-4064-0582</orcidid><orcidid>https://orcid.org/0000-0002-2387-9973</orcidid><orcidid>https://orcid.org/0000-0002-4244-8335</orcidid><orcidid>https://orcid.org/0000-0001-6557-4521</orcidid><orcidid>https://orcid.org/0000-0003-1571-7592</orcidid><orcidid>https://orcid.org/0000-0001-7307-3786</orcidid><orcidid>https://orcid.org/0000-0001-7087-8570</orcidid><orcidid>https://orcid.org/0000-0002-8012-1931</orcidid><orcidid>https://orcid.org/0000-0003-0534-3048</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1558-8238 |
| ispartof | The Journal of clinical investigation, 2024-12, Vol.134 (24) |
| issn | 1558-8238 0021-9738 1558-8238 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11645151 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Care and treatment Citric Acid Cycle Clinical Medicine Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetic nephropathies Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diagnosis Female Humans Insulin Resistance Kidney - metabolism Kidney - pathology Male Metabolomics Oxidation-Reduction Oxidative stress Type 1 diabetes Young Adult |
| title | Attenuated kidney oxidative metabolism in young adults with type 1 diabetes |
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