Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice
Adequate sleep is essential for maintaining cognitive function, as evidenced by literature. var. (PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not ye...
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| Veröffentlicht in: | Nutrients 2024-12, Vol.16 (23), p.4224 |
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| creator | Seo, Chae-Ryeong Lee, Bo Kyung Jee, Hye Jin Yoo, Jae Ryeong Lee, Chul-Kyu Park, Jin Wook Jung, Yi-Sook |
| description | Adequate sleep is essential for maintaining cognitive function, as evidenced by literature.
var.
(PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not yet been evaluated. This study aims to evaluate the effects of fermented PF (FPF) and its underlying mechanisms in a model of SD-induced cognitive impairment.
Mice were subjected to SD to establish cognitive impairment, and FPF was administered once daily for 3 days. Cognitive performance was assessed using Y-maze and passive avoidance tests, followed by molecular mechanisms analyses.
FPF treatment improved SD-induced cognitive impairment, as evidenced by increased spontaneous alternation and extended latency time. Histological analysis revealed that SD impaired the hippocampus, and this impairment was alleviated by FPF treatment. FPF demonstrated antioxidant activity by increasing glutathione levels and decreasing malondialdehyde levels. Furthermore, the decreased levels of brain-derived neurotrophic factor (BDNF) observed in sleep-deprived mice were restored with FPF treatment. FPF also enhanced the phosphorylation of tropomyosin receptor kinase B, extracellular signal-regulated kinase, and cAMP response element-binding protein.
These results indicate that FPF may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression. |
| doi_str_mv | 10.3390/nu16234224 |
| format | Article |
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var.
(PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not yet been evaluated. This study aims to evaluate the effects of fermented PF (FPF) and its underlying mechanisms in a model of SD-induced cognitive impairment.
Mice were subjected to SD to establish cognitive impairment, and FPF was administered once daily for 3 days. Cognitive performance was assessed using Y-maze and passive avoidance tests, followed by molecular mechanisms analyses.
FPF treatment improved SD-induced cognitive impairment, as evidenced by increased spontaneous alternation and extended latency time. Histological analysis revealed that SD impaired the hippocampus, and this impairment was alleviated by FPF treatment. FPF demonstrated antioxidant activity by increasing glutathione levels and decreasing malondialdehyde levels. Furthermore, the decreased levels of brain-derived neurotrophic factor (BDNF) observed in sleep-deprived mice were restored with FPF treatment. FPF also enhanced the phosphorylation of tropomyosin receptor kinase B, extracellular signal-regulated kinase, and cAMP response element-binding protein.
These results indicate that FPF may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16234224</identifier><identifier>PMID: 39683616</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer's disease ; Analysis ; Animal cognition ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - metabolism ; Cognitive ability ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - etiology ; Cyclic AMP Response Element-Binding Protein - metabolism ; Dementia ; Disease Models, Animal ; Fermentation ; Glutathione - metabolism ; Health care ; Hippocampus - drug effects ; Hippocampus - metabolism ; Kinases ; Male ; Maze Learning ; Medicine, Botanic ; Medicine, Herbal ; Memory ; Mice ; Nervous system ; Neurophysiology ; Oxidative stress ; Oxidative Stress - drug effects ; Perilla frutescens - chemistry ; Plant Extracts - pharmacology ; Protein binding ; Receptor, trkB - metabolism ; Signal Transduction - drug effects ; Sleep deprivation ; Sleep Deprivation - complications ; Sleep Deprivation - metabolism ; Sleep disorders ; Type 2 diabetes</subject><ispartof>Nutrients, 2024-12, Vol.16 (23), p.4224</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c327t-857089a1a25673df4114c6e85222082864d80ad42536763130704bd30dd52f883</cites><orcidid>0000-0001-7078-2077 ; 0000-0001-8284-7237</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644480/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644480/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39683616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Chae-Ryeong</creatorcontrib><creatorcontrib>Lee, Bo Kyung</creatorcontrib><creatorcontrib>Jee, Hye Jin</creatorcontrib><creatorcontrib>Yoo, Jae Ryeong</creatorcontrib><creatorcontrib>Lee, Chul-Kyu</creatorcontrib><creatorcontrib>Park, Jin Wook</creatorcontrib><creatorcontrib>Jung, Yi-Sook</creatorcontrib><title>Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Adequate sleep is essential for maintaining cognitive function, as evidenced by literature.
var.
(PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not yet been evaluated. This study aims to evaluate the effects of fermented PF (FPF) and its underlying mechanisms in a model of SD-induced cognitive impairment.
Mice were subjected to SD to establish cognitive impairment, and FPF was administered once daily for 3 days. Cognitive performance was assessed using Y-maze and passive avoidance tests, followed by molecular mechanisms analyses.
FPF treatment improved SD-induced cognitive impairment, as evidenced by increased spontaneous alternation and extended latency time. Histological analysis revealed that SD impaired the hippocampus, and this impairment was alleviated by FPF treatment. FPF demonstrated antioxidant activity by increasing glutathione levels and decreasing malondialdehyde levels. Furthermore, the decreased levels of brain-derived neurotrophic factor (BDNF) observed in sleep-deprived mice were restored with FPF treatment. FPF also enhanced the phosphorylation of tropomyosin receptor kinase B, extracellular signal-regulated kinase, and cAMP response element-binding protein.
These results indicate that FPF may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression.</description><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>Dementia</subject><subject>Disease Models, Animal</subject><subject>Fermentation</subject><subject>Glutathione - metabolism</subject><subject>Health care</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Kinases</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Memory</subject><subject>Mice</subject><subject>Nervous system</subject><subject>Neurophysiology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Perilla frutescens - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Protein binding</subject><subject>Receptor, trkB - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Sleep deprivation</subject><subject>Sleep Deprivation - complications</subject><subject>Sleep Deprivation - metabolism</subject><subject>Sleep disorders</subject><subject>Type 2 diabetes</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkttu1DAQhiMEolXpDQ-ALHGDkLb4FMe5Qsu2W1YqB6nl2nLjcdZVYi9OsoL34IE725YeEPaFR-Nv_tE_mqJ4zeiREDX9ECemuJCcy2fFPqcVnyklxfNH8V5xOAxXdHcqWinxstgTtdJCMbVf_Jn30IWU7RhiS068h2YkyZMl5B7iCI58hxy6zhKfpxGGBuJAUiTnHcCGHMMmhy3WpjhbRTc1yC9SG8MYtkBW_caGGxlysc5patdkHpH9FZzFnI2OfDr-uiTnoY222_UPkXwJDbwqXnjbDXB49x4UP5YnF4vPs7Nvp6vF_GzWCF6NM11WVNeWWV6qSjgvGZONAl1yzqnmWkmnqXWSl0KhbybQv7x0gjpXcq-1OCg-3upupsseHHobs-0Meupt_m2SDebpTwxr06atYUxJKTVFhXd3Cjn9nGAYTR9wRjivCGkajGBS1YyWWiL69h_0Kk0Zjd9QkomSM_1AtbYDE6JP2LjZiZq5ZnWNVmiF1NF_KLwO-tCkCD5g_knB-9uCJqdhyODvTTJqdntkHvYI4TePx3KP_t0acQ2a3MFI</recordid><startdate>20241206</startdate><enddate>20241206</enddate><creator>Seo, Chae-Ryeong</creator><creator>Lee, Bo Kyung</creator><creator>Jee, Hye Jin</creator><creator>Yoo, Jae Ryeong</creator><creator>Lee, Chul-Kyu</creator><creator>Park, Jin Wook</creator><creator>Jung, Yi-Sook</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7078-2077</orcidid><orcidid>https://orcid.org/0000-0001-8284-7237</orcidid></search><sort><creationdate>20241206</creationdate><title>Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice</title><author>Seo, Chae-Ryeong ; Lee, Bo Kyung ; Jee, Hye Jin ; Yoo, Jae Ryeong ; Lee, Chul-Kyu ; Park, Jin Wook ; Jung, Yi-Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-857089a1a25673df4114c6e85222082864d80ad42536763130704bd30dd52f883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Brain</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>Dementia</topic><topic>Disease Models, Animal</topic><topic>Fermentation</topic><topic>Glutathione - metabolism</topic><topic>Health care</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Kinases</topic><topic>Male</topic><topic>Maze Learning</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Memory</topic><topic>Mice</topic><topic>Nervous system</topic><topic>Neurophysiology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Perilla frutescens - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Protein binding</topic><topic>Receptor, trkB - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Sleep deprivation</topic><topic>Sleep Deprivation - complications</topic><topic>Sleep Deprivation - metabolism</topic><topic>Sleep disorders</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Chae-Ryeong</creatorcontrib><creatorcontrib>Lee, Bo Kyung</creatorcontrib><creatorcontrib>Jee, Hye Jin</creatorcontrib><creatorcontrib>Yoo, Jae Ryeong</creatorcontrib><creatorcontrib>Lee, Chul-Kyu</creatorcontrib><creatorcontrib>Park, Jin Wook</creatorcontrib><creatorcontrib>Jung, Yi-Sook</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Chae-Ryeong</au><au>Lee, Bo Kyung</au><au>Jee, Hye Jin</au><au>Yoo, Jae Ryeong</au><au>Lee, Chul-Kyu</au><au>Park, Jin Wook</au><au>Jung, Yi-Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2024-12-06</date><risdate>2024</risdate><volume>16</volume><issue>23</issue><spage>4224</spage><pages>4224-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Adequate sleep is essential for maintaining cognitive function, as evidenced by literature.
var.
(PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not yet been evaluated. This study aims to evaluate the effects of fermented PF (FPF) and its underlying mechanisms in a model of SD-induced cognitive impairment.
Mice were subjected to SD to establish cognitive impairment, and FPF was administered once daily for 3 days. Cognitive performance was assessed using Y-maze and passive avoidance tests, followed by molecular mechanisms analyses.
FPF treatment improved SD-induced cognitive impairment, as evidenced by increased spontaneous alternation and extended latency time. Histological analysis revealed that SD impaired the hippocampus, and this impairment was alleviated by FPF treatment. FPF demonstrated antioxidant activity by increasing glutathione levels and decreasing malondialdehyde levels. Furthermore, the decreased levels of brain-derived neurotrophic factor (BDNF) observed in sleep-deprived mice were restored with FPF treatment. FPF also enhanced the phosphorylation of tropomyosin receptor kinase B, extracellular signal-regulated kinase, and cAMP response element-binding protein.
These results indicate that FPF may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39683616</pmid><doi>10.3390/nu16234224</doi><orcidid>https://orcid.org/0000-0001-7078-2077</orcidid><orcidid>https://orcid.org/0000-0001-8284-7237</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Alzheimer's disease Analysis Animal cognition Animals Antioxidants Antioxidants - pharmacology Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cyclic AMP Response Element-Binding Protein - metabolism Dementia Disease Models, Animal Fermentation Glutathione - metabolism Health care Hippocampus - drug effects Hippocampus - metabolism Kinases Male Maze Learning Medicine, Botanic Medicine, Herbal Memory Mice Nervous system Neurophysiology Oxidative stress Oxidative Stress - drug effects Perilla frutescens - chemistry Plant Extracts - pharmacology Protein binding Receptor, trkB - metabolism Signal Transduction - drug effects Sleep deprivation Sleep Deprivation - complications Sleep Deprivation - metabolism Sleep disorders Type 2 diabetes |
| title | Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice |
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