Sirtuin Proteins and Memory: A Promising Target in Alzheimer's Disease Therapy?
Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved in a wide range of biological processes. Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular com...
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| Veröffentlicht in: | Nutrients 2024-11, Vol.16 (23), p.4088 |
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| creator | Fernandez, Francesca Griffiths, Lyn R Sutherland, Heidi G Cole, Michael H Fitton, J Helen Winberg, Pia Schweitzer, Daniel Hopkins, Lloyd N Meyer, Barbara J |
| description | Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved in a wide range of biological processes. Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular compartments. There has been considerable interest in the role of SIRTs in the brain due to their role in a plethora of metabolic- and age-related diseases, including their involvement in learning and memory function in physiological and pathophysiological conditions. Although cognitive function declines over the course of healthy ageing, neurological disorders including Alzheimer's disease (AD) can be associated with progressive cognitive impairments. This review aimed to report and integrate recent advances in the understanding of the role of SIRTs in cognitive function and dysfunction in the context of AD. We have also reviewed the use of selective and/or natural SIRT activators as potential therapeutic agents and/or adjuvants for AD. |
| doi_str_mv | 10.3390/nu16234088 |
| format | Article |
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Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular compartments. There has been considerable interest in the role of SIRTs in the brain due to their role in a plethora of metabolic- and age-related diseases, including their involvement in learning and memory function in physiological and pathophysiological conditions. Although cognitive function declines over the course of healthy ageing, neurological disorders including Alzheimer's disease (AD) can be associated with progressive cognitive impairments. This review aimed to report and integrate recent advances in the understanding of the role of SIRTs in cognitive function and dysfunction in the context of AD. We have also reviewed the use of selective and/or natural SIRT activators as potential therapeutic agents and/or adjuvants for AD.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16234088</identifier><identifier>PMID: 39683482</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Advertising executives ; Alzheimer Disease - drug therapy ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Animals ; Apoptosis ; Australia ; Brain - drug effects ; Brain - metabolism ; Brain research ; Cancer therapies ; Cell cycle ; Cell death ; Cognition - drug effects ; Cognition - physiology ; Cytokines ; Diseases ; DNA repair ; Humans ; Kinases ; Memory ; Memory - drug effects ; Metabolism ; Oxidative stress ; Physiological aspects ; Physiology ; Proteins ; Review ; Roles ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Sirtuins - metabolism ; Tumor necrosis factor-TNF</subject><ispartof>Nutrients, 2024-11, Vol.16 (23), p.4088</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Advertising executives Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Animals Apoptosis Australia Brain - drug effects Brain - metabolism Brain research Cancer therapies Cell cycle Cell death Cognition - drug effects Cognition - physiology Cytokines Diseases DNA repair Humans Kinases Memory Memory - drug effects Metabolism Oxidative stress Physiological aspects Physiology Proteins Review Roles Signal Transduction - drug effects Signal Transduction - physiology Sirtuins - metabolism Tumor necrosis factor-TNF |
| title | Sirtuin Proteins and Memory: A Promising Target in Alzheimer's Disease Therapy? |
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