Keto Analogues in Patients with Chronic Kidney Disease with or Without Kidney Transplantation
Keto analogues in combination with a (very) low-protein diet significantly reduces the progression to end-stage kidney disease. The question of their benefit and safety for kidney transplant recipients remains. This study aimed to show the renoprotective effect and safety of the use of this method i...
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| Veröffentlicht in: | Nutrients 2024-11, Vol.16 (23), p.4001 |
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| creator | Kleinová, Patrícia Blichová, Tímea Graňák, Karol Kollár, Andrej Vnučák, Matej Dedinská, Ivana |
| description | Keto analogues in combination with a (very) low-protein diet significantly reduces the progression to end-stage kidney disease. The question of their benefit and safety for kidney transplant recipients remains. This study aimed to show the renoprotective effect and safety of the use of this method in patients with chronic kidney disease and a kidney transplantation.
This was a retrospective monocentric study conducted by the transplant nephrology department in Martin, in which patients with chronic kidney disease, with or without kidney transplant therapy, who received a low-protein diet and supplementation with keto analogues were included (
= 59). The changes in their glomerular filtration rate, proteinemia, calcaemia, weight, and glycaemia and the side effects associated with a low-protein diet and keto analogue use were studied in the patients with chronic kidney disease with or without kidney transplantation.
The kidney transplant recipients had a significantly more advanced stage of chronic kidney disease (
= 0.0001) than the non-transplanted patients at the time of the prescription of the keto analogues (
= 0.0001). Furthermore, the kidney transplant recipients had a significantly longer follow-up period (
= 0.0001), with a difference of 27 months within subgroups. During the observed period, we recorded a decrease in glomerular filtration, but without statistical significance. In our group, we did not confirm a significant occurrence of adverse effects associated with a low-protein diet and keto analogues.
Keto analogues reduce the progression of chronic kidney disease and stabilise glomerular filtration in patients with chronic kidney disease. Based on our analysis, treatment with keto analogues is effective and safe for kidney transplant recipients after kidney transplantation. |
| doi_str_mv | 10.3390/nu16234001 |
| format | Article |
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This was a retrospective monocentric study conducted by the transplant nephrology department in Martin, in which patients with chronic kidney disease, with or without kidney transplant therapy, who received a low-protein diet and supplementation with keto analogues were included (
= 59). The changes in their glomerular filtration rate, proteinemia, calcaemia, weight, and glycaemia and the side effects associated with a low-protein diet and keto analogue use were studied in the patients with chronic kidney disease with or without kidney transplantation.
The kidney transplant recipients had a significantly more advanced stage of chronic kidney disease (
= 0.0001) than the non-transplanted patients at the time of the prescription of the keto analogues (
= 0.0001). Furthermore, the kidney transplant recipients had a significantly longer follow-up period (
= 0.0001), with a difference of 27 months within subgroups. During the observed period, we recorded a decrease in glomerular filtration, but without statistical significance. In our group, we did not confirm a significant occurrence of adverse effects associated with a low-protein diet and keto analogues.
Keto analogues reduce the progression of chronic kidney disease and stabilise glomerular filtration in patients with chronic kidney disease. Based on our analysis, treatment with keto analogues is effective and safe for kidney transplant recipients after kidney transplantation.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16234001</identifier><identifier>PMID: 39683395</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acidosis ; Adult ; Adults ; Age ; Aged ; Amino acids ; Care and treatment ; Chronic kidney failure ; Development and progression ; Diabetes ; Diet ; Diet, Protein-Restricted - methods ; Dietary Supplements ; Disease Progression ; Drug therapy ; Exercise ; Female ; Glomerular Filtration Rate - drug effects ; Hemodialysis ; Humans ; Keto Acids - administration & dosage ; Kidney diseases ; Kidney Transplantation ; Kidney transplants ; Life expectancy ; Male ; Medical research ; Medicine, Experimental ; Metabolism ; Metabolites ; Middle Aged ; Nitrogen ; Organ transplant recipients ; Patient compliance ; Patients ; Phenylketonuria ; Proteins ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Retrospective Studies ; Toxins ; Treatment Outcome ; Vegetarianism</subject><ispartof>Nutrients, 2024-11, Vol.16 (23), p.4001</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-eb48de6bfbb9078f75ff50d8a56c087f8ab88d6fac16d1e95e9840072def48453</cites><orcidid>0009-0003-3303-2164 ; 0000-0001-8834-0365 ; 0000-0003-1761-1425 ; 0009-0001-5156-5226 ; 0000-0002-8246-4268</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11643585/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11643585/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39683395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleinová, Patrícia</creatorcontrib><creatorcontrib>Blichová, Tímea</creatorcontrib><creatorcontrib>Graňák, Karol</creatorcontrib><creatorcontrib>Kollár, Andrej</creatorcontrib><creatorcontrib>Vnučák, Matej</creatorcontrib><creatorcontrib>Dedinská, Ivana</creatorcontrib><title>Keto Analogues in Patients with Chronic Kidney Disease with or Without Kidney Transplantation</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Keto analogues in combination with a (very) low-protein diet significantly reduces the progression to end-stage kidney disease. The question of their benefit and safety for kidney transplant recipients remains. This study aimed to show the renoprotective effect and safety of the use of this method in patients with chronic kidney disease and a kidney transplantation.
This was a retrospective monocentric study conducted by the transplant nephrology department in Martin, in which patients with chronic kidney disease, with or without kidney transplant therapy, who received a low-protein diet and supplementation with keto analogues were included (
= 59). The changes in their glomerular filtration rate, proteinemia, calcaemia, weight, and glycaemia and the side effects associated with a low-protein diet and keto analogue use were studied in the patients with chronic kidney disease with or without kidney transplantation.
The kidney transplant recipients had a significantly more advanced stage of chronic kidney disease (
= 0.0001) than the non-transplanted patients at the time of the prescription of the keto analogues (
= 0.0001). Furthermore, the kidney transplant recipients had a significantly longer follow-up period (
= 0.0001), with a difference of 27 months within subgroups. During the observed period, we recorded a decrease in glomerular filtration, but without statistical significance. In our group, we did not confirm a significant occurrence of adverse effects associated with a low-protein diet and keto analogues.
Keto analogues reduce the progression of chronic kidney disease and stabilise glomerular filtration in patients with chronic kidney disease. Based on our analysis, treatment with keto analogues is effective and safe for kidney transplant recipients after kidney transplantation.</description><subject>Acidosis</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Amino acids</subject><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Diet, Protein-Restricted - methods</subject><subject>Dietary Supplements</subject><subject>Disease Progression</subject><subject>Drug therapy</subject><subject>Exercise</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Keto Acids - administration & dosage</subject><subject>Kidney diseases</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Life expectancy</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Nitrogen</subject><subject>Organ transplant recipients</subject><subject>Patient compliance</subject><subject>Patients</subject><subject>Phenylketonuria</subject><subject>Proteins</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Retrospective Studies</subject><subject>Toxins</subject><subject>Treatment Outcome</subject><subject>Vegetarianism</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptksFuGyEQhlHUqolcX_oA0Uq9VJHswMKy7KmynLaJYik9pMopQiw72ERrcGA3ld--uLYTJwocBjHf_DA_IPSF4DGlFT53PeE5ZRiTI3SS4zIfcc7oh4P1MRrG-IA3o8Qlp5_QMa24SNXFCbq_hs5nE6daP-8hZtZlv1VnwXUx-2u7RTZdBO-szq5t42CdXdgIKsI250N2l6Lvu336NigXV61yXRLx7jP6aFQbYbiLA_Tn54_b6eVodvPrajqZjTTltBtBzUQDvDZ1XeFSmLIwpsCNUAXXWJRGqFqIhhulCW8IVAVUInVc5g0YJlhBB-j7VnfV10todLp-UK1cBbtUYS29svJ1xtmFnPsnSUgyqBAbhW87heAfkxGdXNqooU2tgO-jpITxiuQ5yxP69Q364PuQHPxPMUJJTg-ouWpBWmd8OlhvROVEkKoqKBUsUeN3qDQbWFrtHRib9l8VnG0LdPAxBjDPTRIsNx9CvnyIBJ8e2vKM7p-f_gMHcK_m</recordid><startdate>20241122</startdate><enddate>20241122</enddate><creator>Kleinová, Patrícia</creator><creator>Blichová, Tímea</creator><creator>Graňák, Karol</creator><creator>Kollár, Andrej</creator><creator>Vnučák, Matej</creator><creator>Dedinská, Ivana</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0003-3303-2164</orcidid><orcidid>https://orcid.org/0000-0001-8834-0365</orcidid><orcidid>https://orcid.org/0000-0003-1761-1425</orcidid><orcidid>https://orcid.org/0009-0001-5156-5226</orcidid><orcidid>https://orcid.org/0000-0002-8246-4268</orcidid></search><sort><creationdate>20241122</creationdate><title>Keto Analogues in Patients with Chronic Kidney Disease with or Without Kidney Transplantation</title><author>Kleinová, Patrícia ; 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The question of their benefit and safety for kidney transplant recipients remains. This study aimed to show the renoprotective effect and safety of the use of this method in patients with chronic kidney disease and a kidney transplantation.
This was a retrospective monocentric study conducted by the transplant nephrology department in Martin, in which patients with chronic kidney disease, with or without kidney transplant therapy, who received a low-protein diet and supplementation with keto analogues were included (
= 59). The changes in their glomerular filtration rate, proteinemia, calcaemia, weight, and glycaemia and the side effects associated with a low-protein diet and keto analogue use were studied in the patients with chronic kidney disease with or without kidney transplantation.
The kidney transplant recipients had a significantly more advanced stage of chronic kidney disease (
= 0.0001) than the non-transplanted patients at the time of the prescription of the keto analogues (
= 0.0001). Furthermore, the kidney transplant recipients had a significantly longer follow-up period (
= 0.0001), with a difference of 27 months within subgroups. During the observed period, we recorded a decrease in glomerular filtration, but without statistical significance. In our group, we did not confirm a significant occurrence of adverse effects associated with a low-protein diet and keto analogues.
Keto analogues reduce the progression of chronic kidney disease and stabilise glomerular filtration in patients with chronic kidney disease. Based on our analysis, treatment with keto analogues is effective and safe for kidney transplant recipients after kidney transplantation.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39683395</pmid><doi>10.3390/nu16234001</doi><orcidid>https://orcid.org/0009-0003-3303-2164</orcidid><orcidid>https://orcid.org/0000-0001-8834-0365</orcidid><orcidid>https://orcid.org/0000-0003-1761-1425</orcidid><orcidid>https://orcid.org/0009-0001-5156-5226</orcidid><orcidid>https://orcid.org/0000-0002-8246-4268</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acidosis Adult Adults Age Aged Amino acids Care and treatment Chronic kidney failure Development and progression Diabetes Diet Diet, Protein-Restricted - methods Dietary Supplements Disease Progression Drug therapy Exercise Female Glomerular Filtration Rate - drug effects Hemodialysis Humans Keto Acids - administration & dosage Kidney diseases Kidney Transplantation Kidney transplants Life expectancy Male Medical research Medicine, Experimental Metabolism Metabolites Middle Aged Nitrogen Organ transplant recipients Patient compliance Patients Phenylketonuria Proteins Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Retrospective Studies Toxins Treatment Outcome Vegetarianism |
| title | Keto Analogues in Patients with Chronic Kidney Disease with or Without Kidney Transplantation |
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