Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is caused by the absence of the full form of the dystrophin protein, which is essential for maintaining the structural integrity of muscle cells, including those in the heart and respiratory system. Despite progress in understanding the molecular mechanisms associat...

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Veröffentlicht in:	The Journal of pathology 2025-01, Vol.265 (1), p.1-13
Hauptverfasser:	Milan, Marika, Maiullari, Fabio, Chirivì, Maila, Ceraolo, Maria Grazia, Zigiotto, Rebecca, Soluri, Andrea, Maiullari, Silvia, Landoni, Elisa, Silvestre, Dario Di, Brambilla, Francesca, Mauri, Pierluigi, De Paolis, Veronica, Fratini, Nicole, Crosti, Maria Cristina, Cordiglieri, Chiara, Parisi, Chiara, Calogero, Antonella, Seliktar, Dror, Torrente, Yvan, Lanzuolo, Chiara, Dotti, Gianpietro, Toccafondi, Mirco, Bombaci, Mauro, De Falco, Elena, Bearzi, Claudia, Rizzi, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac fibrosis cardiac innervation Cardiac muscle Cardiomyopathy Cell interactions Chondroitin sulfate Chondroitin Sulfate Proteoglycans - metabolism Dilated cardiomyopathy Disease Models, Animal DMD heart failure Duchenne's muscular dystrophy Dystrophin extracellular matrix Fibrosis Histone deacetylase inflammation Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred mdx Microenvironments Molecular modelling Muscular dystrophy Muscular Dystrophy, Duchenne - metabolism Muscular Dystrophy, Duchenne - pathology Myocardium - metabolism Myocardium - pathology Neuromuscular Junction - drug effects Neuromuscular Junction - metabolism Neuromuscular Junction - pathology Original Proteoglycans Respiratory system
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