Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε

During chromosome replication, the nascent leading strand is synthesized by DNA polymerase epsilon (Pol ε), which associates with the sliding clamp processivity factor proliferating cell nuclear antigen (PCNA) to form a processive holoenzyme. For high-fidelity DNA synthesis, Pol ε relies on nucleoti...

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