The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass

The effects of growth-suppressing and muscle-wasting treatments on muscle protein turnover and amino acid concentrations were determined in vivo. All treatments depressed protein synthesis and some treatments depressed protein breakdown. Only prolonged starvation increased protein breakdown. Muscle...

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Veröffentlicht in:	Biochemical journal 1976-04, Vol.156 (1), p.185-188
Hauptverfasser:	Millward, D J, Garlick, P J, Nnanyelugo, D O, Waterlow, J C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus - chemically induced Diabetes Mellitus - metabolism Glucocorticoids Hypophysectomy Isoleucine - analysis Leucine - analysis Male Methionine - analysis Muscle Proteins - biosynthesis Muscle Proteins - metabolism Muscles - anatomy & histology Muscles - metabolism Rats RNA, Ribosomal - metabolism Starvation Streptozocin Valine - analysis
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container_title	Biochemical journal
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creator	Millward, D J Garlick, P J Nnanyelugo, D O Waterlow, J C
description	The effects of growth-suppressing and muscle-wasting treatments on muscle protein turnover and amino acid concentrations were determined in vivo. All treatments depressed protein synthesis and some treatments depressed protein breakdown. Only prolonged starvation increased protein breakdown. Muscle protein mass is regulated primarily through alterations in protein synthesis in all except emergency conditions. The increased concentrations of the branched-chain amino acids indicate that they are unlikely to be involved in this regulation.
doi_str_mv	10.1042/bj1560185
format	Article
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subjects	Animals Diabetes Mellitus - chemically induced Diabetes Mellitus - metabolism Glucocorticoids Hypophysectomy Isoleucine - analysis Leucine - analysis Male Methionine - analysis Muscle Proteins - biosynthesis Muscle Proteins - metabolism Muscles - anatomy & histology Muscles - metabolism Rats RNA, Ribosomal - metabolism Starvation Streptozocin Valine - analysis
title	The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass
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