α‐Mangostin Attenuates Blood Pressure and Reverses Vascular Remodeling by Balancing ACE/AT1R and ACE2/Ang‐(1–7)/MasR Axes in Ang II‐Infused Hypertensive Mice

ABSTRACT Hyperuricemia is a common comorbidity of hypertension and probably has a causal relationship with hypertension. Alpha‐mangostin (α‐MG) has been reported to have uric acid lowering effect. This study aimed to investigate the dual effects of α‐MG on blood pressure (BP) and uric acid levels in...

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Veröffentlicht in:	Phytotherapy research 2024-12, Vol.38 (12), p.5918-5929
Hauptverfasser:	Xue, Qi‐Qi, Liu, Chu‐Hao, Zhang, Dong‐Yan, Li, Ming‐Xuan, Li, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 alpha‐mangostin Angiotensin AT1 receptors Angiotensin I Angiotensin II Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals antihypertensive effect Aorta Aorta - drug effects Balancing Blood pressure Blood Pressure - drug effects blood serum collagen Comorbidity Coronary vessels Down-regulation drugs enzymes Hypertension Hypertension - drug therapy Hypertension - metabolism Hyperuricemia Hyperuricemia - chemically induced Hyperuricemia - drug therapy Ii system Male males Mice Mice, Inbred C57BL Peptide Fragments Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism phytotherapy Pressure effects Receptor, Angiotensin, Type 1 - metabolism Receptors Receptors, G-Protein-Coupled - metabolism Renin Renin-Angiotensin System - drug effects renin–angiotensin system Structure-function relationships Uric acid Uric Acid - blood Vascular Remodeling - drug effects Xanthones - pharmacology
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