Single‐cell transcriptomic atlas of taste papilla aging
Taste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life‐threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not kn...
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| creator | Ren, Wenwen Li, Weihao Cha, Xudong Wang, Shenglei Cai, Boyu Wang, Tianyu Li, Fengzhen Li, Tengfei Xie, Yingqi Xu, Zengyi Wang, Zhe Liu, Huanhai Yu, Yiqun |
| description | Taste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life‐threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not known. Using single‐cell RNA Sequencing, differentially expressed genes between aged and young taste papillae are identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. In the Tmem59−/− circumvallate papillae (CVP), taste mature cell generation is impaired by reduction in the numbers of PLCβ2+ and Car4+ cells, as well as decreases in expression levels of taste transduction genes. Tmem59−/− mice showed deficits in sensitivities to tastants. Through screening by GenAge and DisGeNET databases, aging‐dependent genes and oral disease‐associated genes are identified in taste papillae. In the CVP, aging promotes intercellular communication reciprocally between (cycling) basal cell and mature taste cell by upregulated Crlf1/Lifr and Adam15/Itga5 signaling. By transcriptional network analysis, ribosome proteins, Anxa1, Prdx5, and Hmgb1/2 are identified as transcriptional hubs in the aged taste papillae. Chronological aging‐associated transcriptional changes throughout taste cell maturation are revealed. Aged taste papillae contain more Muc5b+ cells that are not localized in gustatory gland. Collectively, this study shows molecular and cellular features associated with taste papilla aging.
Differentially expressed genes between aged and young taste papillae were identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. Impairing taste receptor cell generation and decreases in expression levels of taste transduction genes were found in the Tmem59−/− circumvallate papillae, and Tmem59−/− mice showed deficits in sensitivities to tastants. |
| doi_str_mv | 10.1111/acel.14308 |
| format | Article |
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Differentially expressed genes between aged and young taste papillae were identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. Impairing taste receptor cell generation and decreases in expression levels of taste transduction genes were found in the Tmem59−/− circumvallate papillae, and Tmem59−/− mice showed deficits in sensitivities to tastants.</description><identifier>ISSN: 1474-9718</identifier><identifier>ISSN: 1474-9726</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/acel.14308</identifier><identifier>PMID: 39169434</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aging ; Aging - genetics ; Animals ; Antibodies ; Cell interactions ; Cells ; circumvallate papillae ; foliate papillae ; Genes ; HMGB1 protein ; Hybridization ; Laboratories ; mature taste cell ; Mice ; Older people ; Papillae ; Proteins ; Signal transduction ; Single-Cell Analysis ; single‐cell RNA sequencing ; Taste ; Taste Buds - metabolism ; Taste disorders ; Taste perception ; Taste receptors ; Taste transduction ; Tongue ; Transcription ; Transcriptome - genetics ; Transcriptomics</subject><ispartof>Aging cell, 2024-12, Vol.23 (12), p.e14308-n/a</ispartof><rights>2024 The Author(s). published by Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 The Author(s). Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5256-7082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634696/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634696/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39169434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Wenwen</creatorcontrib><creatorcontrib>Li, Weihao</creatorcontrib><creatorcontrib>Cha, Xudong</creatorcontrib><creatorcontrib>Wang, Shenglei</creatorcontrib><creatorcontrib>Cai, Boyu</creatorcontrib><creatorcontrib>Wang, Tianyu</creatorcontrib><creatorcontrib>Li, Fengzhen</creatorcontrib><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Xie, Yingqi</creatorcontrib><creatorcontrib>Xu, Zengyi</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Liu, Huanhai</creatorcontrib><creatorcontrib>Yu, Yiqun</creatorcontrib><title>Single‐cell transcriptomic atlas of taste papilla aging</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Taste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life‐threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not known. Using single‐cell RNA Sequencing, differentially expressed genes between aged and young taste papillae are identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. In the Tmem59−/− circumvallate papillae (CVP), taste mature cell generation is impaired by reduction in the numbers of PLCβ2+ and Car4+ cells, as well as decreases in expression levels of taste transduction genes. Tmem59−/− mice showed deficits in sensitivities to tastants. Through screening by GenAge and DisGeNET databases, aging‐dependent genes and oral disease‐associated genes are identified in taste papillae. In the CVP, aging promotes intercellular communication reciprocally between (cycling) basal cell and mature taste cell by upregulated Crlf1/Lifr and Adam15/Itga5 signaling. By transcriptional network analysis, ribosome proteins, Anxa1, Prdx5, and Hmgb1/2 are identified as transcriptional hubs in the aged taste papillae. Chronological aging‐associated transcriptional changes throughout taste cell maturation are revealed. Aged taste papillae contain more Muc5b+ cells that are not localized in gustatory gland. Collectively, this study shows molecular and cellular features associated with taste papilla aging.
Differentially expressed genes between aged and young taste papillae were identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. Impairing taste receptor cell generation and decreases in expression levels of taste transduction genes were found in the Tmem59−/− circumvallate papillae, and Tmem59−/− mice showed deficits in sensitivities to tastants.</description><subject>Aging</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Cell interactions</subject><subject>Cells</subject><subject>circumvallate papillae</subject><subject>foliate papillae</subject><subject>Genes</subject><subject>HMGB1 protein</subject><subject>Hybridization</subject><subject>Laboratories</subject><subject>mature taste cell</subject><subject>Mice</subject><subject>Older people</subject><subject>Papillae</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Single-Cell Analysis</subject><subject>single‐cell RNA sequencing</subject><subject>Taste</subject><subject>Taste Buds - metabolism</subject><subject>Taste disorders</subject><subject>Taste perception</subject><subject>Taste receptors</subject><subject>Taste transduction</subject><subject>Tongue</subject><subject>Transcription</subject><subject>Transcriptome - genetics</subject><subject>Transcriptomics</subject><issn>1474-9718</issn><issn>1474-9726</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdUclOwzAQtRCIluXCB6BIXLikjGPHywlVVVmkShyAs-WmTnHlLMQpqDc-gW_kS3DaUgFzmZHmzZs38xA6wzDAIa50ZtwAUwJiD_Ux5TSWPGH7uxqLHjryfgGAuQRyiHpEYiYpoX0kH205d-br4zOQuKhtdOmzxtZtVdgs0q3TPqryqNW-NVGta-ucjvQ8DJ2gg1w7b063-Rg934yfRnfx5OH2fjScxDUBImIpMsxmTOaccEFyDpBPgdKMMZbxNIUUBM01JsB1nuoZZkE60yZnQiRSAJBjdL3hrZfTwswyUwaRTtWNLXSzUpW26m-ntC9qXr0pjBmhTLLAcLllaKrXpfGtKqzvztWlqZZeEZAp45zKbtnFP-iiWjZluE-R7sNpAjIJqPPfknZaft4aAHgDeLfOrHZ9DKozTHWGqbVhajgaT9YV-QZI1oe4</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Ren, Wenwen</creator><creator>Li, Weihao</creator><creator>Cha, Xudong</creator><creator>Wang, Shenglei</creator><creator>Cai, Boyu</creator><creator>Wang, Tianyu</creator><creator>Li, Fengzhen</creator><creator>Li, Tengfei</creator><creator>Xie, Yingqi</creator><creator>Xu, Zengyi</creator><creator>Wang, Zhe</creator><creator>Liu, Huanhai</creator><creator>Yu, Yiqun</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5256-7082</orcidid></search><sort><creationdate>202412</creationdate><title>Single‐cell transcriptomic atlas of taste papilla aging</title><author>Ren, Wenwen ; Li, Weihao ; Cha, Xudong ; Wang, Shenglei ; Cai, Boyu ; Wang, Tianyu ; Li, Fengzhen ; Li, Tengfei ; Xie, Yingqi ; Xu, Zengyi ; Wang, Zhe ; Liu, Huanhai ; Yu, Yiqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3038-98c16d69f73783f700fb044c666c75505084fa1307af5ad167266aef688298003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aging</topic><topic>Aging - genetics</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Cell interactions</topic><topic>Cells</topic><topic>circumvallate papillae</topic><topic>foliate papillae</topic><topic>Genes</topic><topic>HMGB1 protein</topic><topic>Hybridization</topic><topic>Laboratories</topic><topic>mature taste cell</topic><topic>Mice</topic><topic>Older people</topic><topic>Papillae</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Single-Cell Analysis</topic><topic>single‐cell RNA sequencing</topic><topic>Taste</topic><topic>Taste Buds - metabolism</topic><topic>Taste disorders</topic><topic>Taste perception</topic><topic>Taste receptors</topic><topic>Taste transduction</topic><topic>Tongue</topic><topic>Transcription</topic><topic>Transcriptome - genetics</topic><topic>Transcriptomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Wenwen</creatorcontrib><creatorcontrib>Li, Weihao</creatorcontrib><creatorcontrib>Cha, Xudong</creatorcontrib><creatorcontrib>Wang, Shenglei</creatorcontrib><creatorcontrib>Cai, Boyu</creatorcontrib><creatorcontrib>Wang, Tianyu</creatorcontrib><creatorcontrib>Li, Fengzhen</creatorcontrib><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Xie, Yingqi</creatorcontrib><creatorcontrib>Xu, Zengyi</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Liu, Huanhai</creatorcontrib><creatorcontrib>Yu, Yiqun</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Wenwen</au><au>Li, Weihao</au><au>Cha, Xudong</au><au>Wang, Shenglei</au><au>Cai, Boyu</au><au>Wang, Tianyu</au><au>Li, Fengzhen</au><au>Li, Tengfei</au><au>Xie, Yingqi</au><au>Xu, Zengyi</au><au>Wang, Zhe</au><au>Liu, Huanhai</au><au>Yu, Yiqun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single‐cell transcriptomic atlas of taste papilla aging</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2024-12</date><risdate>2024</risdate><volume>23</volume><issue>12</issue><spage>e14308</spage><epage>n/a</epage><pages>e14308-n/a</pages><issn>1474-9718</issn><issn>1474-9726</issn><eissn>1474-9726</eissn><abstract>Taste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life‐threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not known. Using single‐cell RNA Sequencing, differentially expressed genes between aged and young taste papillae are identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. In the Tmem59−/− circumvallate papillae (CVP), taste mature cell generation is impaired by reduction in the numbers of PLCβ2+ and Car4+ cells, as well as decreases in expression levels of taste transduction genes. Tmem59−/− mice showed deficits in sensitivities to tastants. Through screening by GenAge and DisGeNET databases, aging‐dependent genes and oral disease‐associated genes are identified in taste papillae. In the CVP, aging promotes intercellular communication reciprocally between (cycling) basal cell and mature taste cell by upregulated Crlf1/Lifr and Adam15/Itga5 signaling. By transcriptional network analysis, ribosome proteins, Anxa1, Prdx5, and Hmgb1/2 are identified as transcriptional hubs in the aged taste papillae. Chronological aging‐associated transcriptional changes throughout taste cell maturation are revealed. Aged taste papillae contain more Muc5b+ cells that are not localized in gustatory gland. Collectively, this study shows molecular and cellular features associated with taste papilla aging.
Differentially expressed genes between aged and young taste papillae were identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. Impairing taste receptor cell generation and decreases in expression levels of taste transduction genes were found in the Tmem59−/− circumvallate papillae, and Tmem59−/− mice showed deficits in sensitivities to tastants.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39169434</pmid><doi>10.1111/acel.14308</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0001-5256-7082</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Aging - genetics Animals Antibodies Cell interactions Cells circumvallate papillae foliate papillae Genes HMGB1 protein Hybridization Laboratories mature taste cell Mice Older people Papillae Proteins Signal transduction Single-Cell Analysis single‐cell RNA sequencing Taste Taste Buds - metabolism Taste disorders Taste perception Taste receptors Taste transduction Tongue Transcription Transcriptome - genetics Transcriptomics |
| title | Single‐cell transcriptomic atlas of taste papilla aging |
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