Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate

The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D3 (1,25D3) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this study we deleted Vdr from Lrig1 expressing stem cells i...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2023-09, Vol.232, p.106352-106352, Article 106352
Hauptverfasser:	Oda, Yuko, Wong, Christian T., Oh, Dennis H., Meyer, Mark B., Pike, J. Wesley, Bikle, Daniel D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell fate Epidermal Cells - metabolism Epidermis - metabolism Epigenetics Keratinocytes - metabolism Keratinocytes, wounding Mice P63 Receptor Cross-Talk Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Transcription Factors - metabolism Vitamin D Vitamin D - metabolism Vitamin D receptor
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