Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds
BACKGROUND Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole‐genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing...
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| Veröffentlicht in: | Pest management science 2025-01, Vol.81 (1), p.298-307 |
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| creator | Yılmaz, Semih Idris, Abeer Babiker Ayvaz, Abdurrahman Temizgül, Rıdvan Çetin, Aysun Hassan, Mohammed A |
| description | BACKGROUND
Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole‐genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing putative pesticidal toxins, antimicrobial metabolites and plant growth‐promoting features.
RESULTS
Our results showed that the SY49.1 genome is 6. 32 Mbp long with a GC content of 34.68%. Genome mining revealed the presence of multiple gene inventories for the biosynthesis of bioactive compounds such as insecticidal delta endotoxins, secondary metabolites, and several plant growth‐promoting proteins. Multiple sequence alignment revealed residue variations in the toxic core of Cry1Ab when compared with known Cry1Ab sequences from Bt nomenclature databases. This suggests that the cry1Ab of SY49.1 is a new kind of its group. Among the predicted secondary metabolites, we found a kurstakin with a predicted peptide that differs from the known kurstakin peptide available in the NORINE database. In addition, lipopeptides extracted from SY49.1 suppressed the growth of Verticillium dahliae and Fusarium oxysporum.
CONCLUSION
We anticipate that the complete genome of Bt SY49.1 may provide a model for properly understanding and studying antimicrobial compound mining, genetic diversity among the B. cereus group, and pathogenicity against insects. This is the first report on the WGS and mining of the Bt strain isolated from Turkey. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
This study identified novel genes responsible for producing putative pesticidal toxins, antimicrobial compounds, and plant growth‐promoting proteins, shedding light on the potential agricultural applications of the Bt SY49.1 strain. |
| doi_str_mv | 10.1002/ps.8433 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11632210</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3154268957</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3273-f5fee81dc6f7dc7658976cd1b87e53662582e1b944afed30b3f38d6b81099b783</originalsourceid><addsrcrecordid>eNqNkl1rFTEQhoMotlbxH0jAG0HOMd-bXIkWrUJBoQp6FbLJbJuSTdbN7pH-e3NoPahXXs0w82R438kg9JSSLSWEvZrqVgvO76FjKpnaCGP0_UOuvx2hR7VeE0KMMewhOuKGMyE1PUbTGeQyAh5jjvkSlwG_dT6mtFa8XK1zq0XINVZcl9nFjC--C7OleIYduFRxLjtI2LscYnAL4AnqEn3LE2413Mfi_BJ3gH0Zp7LmUB-jB0N7CU_u4gn6-v7dl9MPm_NPZx9P35xvJs46vhnkAKBp8Grogu-U1KZTPtBedyC5UkxqBrQ3QrgBAic9H7gOqte0eew7zU_Q69u509qPEDzkZiDZaY6jm29scdH-3cnxyl6WnaVUccYoaRNe3E2Yy4-1GbNjrB5SchnKWi2nUjCljez-A22qOqnUHn3-D3pd1jm3VTRKsE6K5rVRz_5Uf5D9--Ma8PIW-BkT3Bz6lNj9Pdip2v092M8X-8B_Abp6p-g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3142754658</pqid></control><display><type>article</type><title>Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Yılmaz, Semih ; Idris, Abeer Babiker ; Ayvaz, Abdurrahman ; Temizgül, Rıdvan ; Çetin, Aysun ; Hassan, Mohammed A</creator><creatorcontrib>Yılmaz, Semih ; Idris, Abeer Babiker ; Ayvaz, Abdurrahman ; Temizgül, Rıdvan ; Çetin, Aysun ; Hassan, Mohammed A</creatorcontrib><description>BACKGROUND
Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole‐genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing putative pesticidal toxins, antimicrobial metabolites and plant growth‐promoting features.
RESULTS
Our results showed that the SY49.1 genome is 6. 32 Mbp long with a GC content of 34.68%. Genome mining revealed the presence of multiple gene inventories for the biosynthesis of bioactive compounds such as insecticidal delta endotoxins, secondary metabolites, and several plant growth‐promoting proteins. Multiple sequence alignment revealed residue variations in the toxic core of Cry1Ab when compared with known Cry1Ab sequences from Bt nomenclature databases. This suggests that the cry1Ab of SY49.1 is a new kind of its group. Among the predicted secondary metabolites, we found a kurstakin with a predicted peptide that differs from the known kurstakin peptide available in the NORINE database. In addition, lipopeptides extracted from SY49.1 suppressed the growth of Verticillium dahliae and Fusarium oxysporum.
CONCLUSION
We anticipate that the complete genome of Bt SY49.1 may provide a model for properly understanding and studying antimicrobial compound mining, genetic diversity among the B. cereus group, and pathogenicity against insects. This is the first report on the WGS and mining of the Bt strain isolated from Turkey. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
This study identified novel genes responsible for producing putative pesticidal toxins, antimicrobial compounds, and plant growth‐promoting proteins, shedding light on the potential agricultural applications of the Bt SY49.1 strain.</description><identifier>ISSN: 1526-498X</identifier><identifier>ISSN: 1526-4998</identifier><identifier>EISSN: 1526-4998</identifier><identifier>DOI: 10.1002/ps.8433</identifier><identifier>PMID: 39324581</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Annotations ; anti-infective agents ; antifungal properties ; Bacillus cereus ; Bacillus thuringiensis ; Bacillus thuringiensis - genetics ; Bacillus thuringiensis Toxins ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bioactive compounds ; Biocompatibility ; Bioinformatics ; Biological activity ; Biosynthesis ; Endotoxins ; Endotoxins - genetics ; Endotoxins - pharmacology ; Fungicidal activity ; fungicide ; Fungicides ; Fusarium - drug effects ; Fusarium - genetics ; Fusarium - metabolism ; Fusarium oxysporum ; Gene sequencing ; genes ; Genetic diversity ; genetic variation ; genome mining ; Genome, Bacterial ; Genomes ; Genomic analysis ; Hemolysin Proteins - genetics ; Hemolysin Proteins - pharmacology ; Insecticides - pharmacology ; Insects ; Lipopeptides ; Metabolites ; Nomenclature ; Nucleotide sequence ; Pathogenicity ; Pathogens ; Peptides ; Pest control ; pest management ; pesticide ; Pesticides ; Pests ; PGPR ; Plant growth ; plant pathogens ; Secondary metabolites ; sequence alignment ; toxicity ; Toxins ; Verticillium dahliae ; Whole Genome Sequencing</subject><ispartof>Pest management science, 2025-01, Vol.81 (1), p.298-307</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</rights><rights>2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-6436-5963 ; 0000-0003-4835-1494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fps.8433$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fps.8433$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39324581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yılmaz, Semih</creatorcontrib><creatorcontrib>Idris, Abeer Babiker</creatorcontrib><creatorcontrib>Ayvaz, Abdurrahman</creatorcontrib><creatorcontrib>Temizgül, Rıdvan</creatorcontrib><creatorcontrib>Çetin, Aysun</creatorcontrib><creatorcontrib>Hassan, Mohammed A</creatorcontrib><title>Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds</title><title>Pest management science</title><addtitle>Pest Manag Sci</addtitle><description>BACKGROUND
Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole‐genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing putative pesticidal toxins, antimicrobial metabolites and plant growth‐promoting features.
RESULTS
Our results showed that the SY49.1 genome is 6. 32 Mbp long with a GC content of 34.68%. Genome mining revealed the presence of multiple gene inventories for the biosynthesis of bioactive compounds such as insecticidal delta endotoxins, secondary metabolites, and several plant growth‐promoting proteins. Multiple sequence alignment revealed residue variations in the toxic core of Cry1Ab when compared with known Cry1Ab sequences from Bt nomenclature databases. This suggests that the cry1Ab of SY49.1 is a new kind of its group. Among the predicted secondary metabolites, we found a kurstakin with a predicted peptide that differs from the known kurstakin peptide available in the NORINE database. In addition, lipopeptides extracted from SY49.1 suppressed the growth of Verticillium dahliae and Fusarium oxysporum.
CONCLUSION
We anticipate that the complete genome of Bt SY49.1 may provide a model for properly understanding and studying antimicrobial compound mining, genetic diversity among the B. cereus group, and pathogenicity against insects. This is the first report on the WGS and mining of the Bt strain isolated from Turkey. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
This study identified novel genes responsible for producing putative pesticidal toxins, antimicrobial compounds, and plant growth‐promoting proteins, shedding light on the potential agricultural applications of the Bt SY49.1 strain.</description><subject>Annotations</subject><subject>anti-infective agents</subject><subject>antifungal properties</subject><subject>Bacillus cereus</subject><subject>Bacillus thuringiensis</subject><subject>Bacillus thuringiensis - genetics</subject><subject>Bacillus thuringiensis Toxins</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bioactive compounds</subject><subject>Biocompatibility</subject><subject>Bioinformatics</subject><subject>Biological activity</subject><subject>Biosynthesis</subject><subject>Endotoxins</subject><subject>Endotoxins - genetics</subject><subject>Endotoxins - pharmacology</subject><subject>Fungicidal activity</subject><subject>fungicide</subject><subject>Fungicides</subject><subject>Fusarium - drug effects</subject><subject>Fusarium - genetics</subject><subject>Fusarium - metabolism</subject><subject>Fusarium oxysporum</subject><subject>Gene sequencing</subject><subject>genes</subject><subject>Genetic diversity</subject><subject>genetic variation</subject><subject>genome mining</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Genomic analysis</subject><subject>Hemolysin Proteins - genetics</subject><subject>Hemolysin Proteins - pharmacology</subject><subject>Insecticides - pharmacology</subject><subject>Insects</subject><subject>Lipopeptides</subject><subject>Metabolites</subject><subject>Nomenclature</subject><subject>Nucleotide sequence</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Peptides</subject><subject>Pest control</subject><subject>pest management</subject><subject>pesticide</subject><subject>Pesticides</subject><subject>Pests</subject><subject>PGPR</subject><subject>Plant growth</subject><subject>plant pathogens</subject><subject>Secondary metabolites</subject><subject>sequence alignment</subject><subject>toxicity</subject><subject>Toxins</subject><subject>Verticillium dahliae</subject><subject>Whole Genome Sequencing</subject><issn>1526-498X</issn><issn>1526-4998</issn><issn>1526-4998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqNkl1rFTEQhoMotlbxH0jAG0HOMd-bXIkWrUJBoQp6FbLJbJuSTdbN7pH-e3NoPahXXs0w82R438kg9JSSLSWEvZrqVgvO76FjKpnaCGP0_UOuvx2hR7VeE0KMMewhOuKGMyE1PUbTGeQyAh5jjvkSlwG_dT6mtFa8XK1zq0XINVZcl9nFjC--C7OleIYduFRxLjtI2LscYnAL4AnqEn3LE2413Mfi_BJ3gH0Zp7LmUB-jB0N7CU_u4gn6-v7dl9MPm_NPZx9P35xvJs46vhnkAKBp8Grogu-U1KZTPtBedyC5UkxqBrQ3QrgBAic9H7gOqte0eew7zU_Q69u509qPEDzkZiDZaY6jm29scdH-3cnxyl6WnaVUccYoaRNe3E2Yy4-1GbNjrB5SchnKWi2nUjCljez-A22qOqnUHn3-D3pd1jm3VTRKsE6K5rVRz_5Uf5D9--Ma8PIW-BkT3Bz6lNj9Pdip2v092M8X-8B_Abp6p-g</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Yılmaz, Semih</creator><creator>Idris, Abeer Babiker</creator><creator>Ayvaz, Abdurrahman</creator><creator>Temizgül, Rıdvan</creator><creator>Çetin, Aysun</creator><creator>Hassan, Mohammed A</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QR</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6436-5963</orcidid><orcidid>https://orcid.org/0000-0003-4835-1494</orcidid></search><sort><creationdate>202501</creationdate><title>Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds</title><author>Yılmaz, Semih ; Idris, Abeer Babiker ; Ayvaz, Abdurrahman ; Temizgül, Rıdvan ; Çetin, Aysun ; Hassan, Mohammed A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3273-f5fee81dc6f7dc7658976cd1b87e53662582e1b944afed30b3f38d6b81099b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Annotations</topic><topic>anti-infective agents</topic><topic>antifungal properties</topic><topic>Bacillus cereus</topic><topic>Bacillus thuringiensis</topic><topic>Bacillus thuringiensis - genetics</topic><topic>Bacillus thuringiensis Toxins</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bioactive compounds</topic><topic>Biocompatibility</topic><topic>Bioinformatics</topic><topic>Biological activity</topic><topic>Biosynthesis</topic><topic>Endotoxins</topic><topic>Endotoxins - genetics</topic><topic>Endotoxins - pharmacology</topic><topic>Fungicidal activity</topic><topic>fungicide</topic><topic>Fungicides</topic><topic>Fusarium - drug effects</topic><topic>Fusarium - genetics</topic><topic>Fusarium - metabolism</topic><topic>Fusarium oxysporum</topic><topic>Gene sequencing</topic><topic>genes</topic><topic>Genetic diversity</topic><topic>genetic variation</topic><topic>genome mining</topic><topic>Genome, Bacterial</topic><topic>Genomes</topic><topic>Genomic analysis</topic><topic>Hemolysin Proteins - genetics</topic><topic>Hemolysin Proteins - pharmacology</topic><topic>Insecticides - pharmacology</topic><topic>Insects</topic><topic>Lipopeptides</topic><topic>Metabolites</topic><topic>Nomenclature</topic><topic>Nucleotide sequence</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Peptides</topic><topic>Pest control</topic><topic>pest management</topic><topic>pesticide</topic><topic>Pesticides</topic><topic>Pests</topic><topic>PGPR</topic><topic>Plant growth</topic><topic>plant pathogens</topic><topic>Secondary metabolites</topic><topic>sequence alignment</topic><topic>toxicity</topic><topic>Toxins</topic><topic>Verticillium dahliae</topic><topic>Whole Genome Sequencing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yılmaz, Semih</creatorcontrib><creatorcontrib>Idris, Abeer Babiker</creatorcontrib><creatorcontrib>Ayvaz, Abdurrahman</creatorcontrib><creatorcontrib>Temizgül, Rıdvan</creatorcontrib><creatorcontrib>Çetin, Aysun</creatorcontrib><creatorcontrib>Hassan, Mohammed A</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pest management science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yılmaz, Semih</au><au>Idris, Abeer Babiker</au><au>Ayvaz, Abdurrahman</au><au>Temizgül, Rıdvan</au><au>Çetin, Aysun</au><au>Hassan, Mohammed A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds</atitle><jtitle>Pest management science</jtitle><addtitle>Pest Manag Sci</addtitle><date>2025-01</date><risdate>2025</risdate><volume>81</volume><issue>1</issue><spage>298</spage><epage>307</epage><pages>298-307</pages><issn>1526-498X</issn><issn>1526-4998</issn><eissn>1526-4998</eissn><abstract>BACKGROUND
Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole‐genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing putative pesticidal toxins, antimicrobial metabolites and plant growth‐promoting features.
RESULTS
Our results showed that the SY49.1 genome is 6. 32 Mbp long with a GC content of 34.68%. Genome mining revealed the presence of multiple gene inventories for the biosynthesis of bioactive compounds such as insecticidal delta endotoxins, secondary metabolites, and several plant growth‐promoting proteins. Multiple sequence alignment revealed residue variations in the toxic core of Cry1Ab when compared with known Cry1Ab sequences from Bt nomenclature databases. This suggests that the cry1Ab of SY49.1 is a new kind of its group. Among the predicted secondary metabolites, we found a kurstakin with a predicted peptide that differs from the known kurstakin peptide available in the NORINE database. In addition, lipopeptides extracted from SY49.1 suppressed the growth of Verticillium dahliae and Fusarium oxysporum.
CONCLUSION
We anticipate that the complete genome of Bt SY49.1 may provide a model for properly understanding and studying antimicrobial compound mining, genetic diversity among the B. cereus group, and pathogenicity against insects. This is the first report on the WGS and mining of the Bt strain isolated from Turkey. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
This study identified novel genes responsible for producing putative pesticidal toxins, antimicrobial compounds, and plant growth‐promoting proteins, shedding light on the potential agricultural applications of the Bt SY49.1 strain.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>39324581</pmid><doi>10.1002/ps.8433</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6436-5963</orcidid><orcidid>https://orcid.org/0000-0003-4835-1494</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Annotations anti-infective agents antifungal properties Bacillus cereus Bacillus thuringiensis Bacillus thuringiensis - genetics Bacillus thuringiensis Toxins Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioactive compounds Biocompatibility Bioinformatics Biological activity Biosynthesis Endotoxins Endotoxins - genetics Endotoxins - pharmacology Fungicidal activity fungicide Fungicides Fusarium - drug effects Fusarium - genetics Fusarium - metabolism Fusarium oxysporum Gene sequencing genes Genetic diversity genetic variation genome mining Genome, Bacterial Genomes Genomic analysis Hemolysin Proteins - genetics Hemolysin Proteins - pharmacology Insecticides - pharmacology Insects Lipopeptides Metabolites Nomenclature Nucleotide sequence Pathogenicity Pathogens Peptides Pest control pest management pesticide Pesticides Pests PGPR Plant growth plant pathogens Secondary metabolites sequence alignment toxicity Toxins Verticillium dahliae Whole Genome Sequencing |
| title | Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds |
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