Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection

[Display omitted] Intestinal intraepithelial T lymphocytes (IEL) constitutively express high amounts of the cytotoxic proteases Granzymes (Gzm) A and B and are therefore thought to protect the intestinal epithelium against infection by killing infected epithelial cells. However, the role of IEL gran...

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Veröffentlicht in:	Mucosal immunology 2024-12, Vol.17 (6), p.1242-1255
Hauptverfasser:	Chawla, Amanpreet Singh, Vandereyken, Maud, Arias, Maykel, Santiago, Llipsy, Dikovskaya, Dina, Nguyen, Chi, Skariah, Neema, Wenner, Nicolas, Golovchenko, Natasha B., Thomson, Sarah J., Ondari, Edna, Garzón-Tituaña, Marcela, Anderson, Christopher J., Bergkessel, Megan, C. D. Hinton, Jay, Edelblum, Karen L., Pardo, Julian, Swamy, Mahima
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Death Disease Models, Animal Granzymes Granzymes - metabolism Humans Infection Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intraepithelial lymphocytes Intraepithelial Lymphocytes - immunology Intraepithelial Lymphocytes - metabolism Mice Mice, Inbred C57BL Mice, Knockout Salmonella Salmonella Infections - immunology Salmonella typhimurium - physiology
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