Genomic instability in non-breast or ovarian malignancies of individuals with germline pathogenic variants in BRCA1/2

Individuals with germline pathogenic variants in BRCA1 or BRCA2 are at a high risk of breast and ovarian carcinomas with BRCA1/2 deficiency and homologous recombination deficiency that can be detected by analysis of genome-wide genomic instability features such as large-scale state transitions, telo...

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