Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study
The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese patients who meet the EF-14 inclusion criteria. This was a multicenter retr...
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| creator | Kanamori, Masayuki Tsuzuki, Shunsuke Shibahara, Ichiyo Saito, Kuniaki Shimoda, Yoshiteru Tanaka, Kazuhiro Yamaguchi, Shigeru Natsumeda, Manabu Matsutani, Tomoo Hanihara, Mitsuto Nakada, Mitsutoshi Kuroda, Jun-Ichiro Matsuda, Masahide Yoshimoto, Koji Yonezawa, Ushio Sonoda, Yukihiko Takano, Koji Yonezawa, Hajime Otani, Yoshihiro Nakahara, Yukiko Uchida, Masashi Nonaka, Masahiro Mineharu, Yohei Kitamura, Yohei Yamashita, Shinji Yamauchi, Takahiro Miyake, Yohei Deguchi, Shoichi Beppu, Takaaki Tamura, Kaoru Koizumi, Shinichiro Hirose, Yuichi Asano, Kenichiro Hiruta, Ryo Kinoshita, Manabu Miyake, Keisuke Nakayama, Noriyuki Inoue, Akihiro Ono, Takahiro Sasaki, Takahiro Akiyama, Yukinori Fukami, Shinjiro Yoshino, Atsuo Kawanishi, Yu Asanome, Taku Yamaguchi, Takuhiro Takahashi, Masamichi Yamasaki, Fumiyuki Arakawa, Yoshiki Narita, Yoshitaka |
| description | The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese patients who meet the EF-14 inclusion criteria.
This was a multicenter retrospective cohort study. Background, treatment, and outcome data of patients who satisfied the inclusion criteria of the EF-14 trial were collected from 45 institutions across Japan. The rate, determinants, and current status of TTField use, including its safety and efficacy in terms of progression and survival, were retrospectively investigated. This study was conducted in accordance with the STROBE checklist.
Among the 607 patients enrolled, 70 were excluded due to progressive disease during radiation and temozolomide therapy, age > 80 years old, and Karnofsky Performance Status score of |
| doi_str_mv | 10.1093/noajnl/vdae176 |
| format | Article |
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This was a multicenter retrospective cohort study. Background, treatment, and outcome data of patients who satisfied the inclusion criteria of the EF-14 trial were collected from 45 institutions across Japan. The rate, determinants, and current status of TTField use, including its safety and efficacy in terms of progression and survival, were retrospectively investigated. This study was conducted in accordance with the STROBE checklist.
Among the 607 patients enrolled, 70 were excluded due to progressive disease during radiation and temozolomide therapy, age > 80 years old, and Karnofsky Performance Status score of <70. Among the remaining 537 patients, 210 (39%) underwent TTField treatment. Multivariate analysis revealed younger age and spouse as a caregiver as significant factors for TTField use. The compliance rate of TTField use exceeded 75% in 60% of patients, with a median TTField usage duration of 11 months. Skin disorders requiring medical treatment occurred in 56% of patients. Multivariate Cox proportional hazards analysis in the whole series and propensity score-matched analysis revealed that TTField use was not a prognostic factor for progression-free survival (PFS) or overall survival (OS).
TTField use did not have a substantial effect on either PFS or OS in Japanese patients with glioblastoma, despite compliance rates comparable to those observed in the EF-14.</description><identifier>ISSN: 2632-2498</identifier><identifier>EISSN: 2632-2498</identifier><identifier>DOI: 10.1093/noajnl/vdae176</identifier><identifier>PMID: 39659832</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Clinical Investigations</subject><ispartof>Neuro-oncology advances, 2024-01, Vol.6 (1), p.vdae176</ispartof><rights>The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.</rights><rights>The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-af511d14b64dd9b7ab04938c894cc417040f755efa8c00febbfb4785359d77943</cites><orcidid>0000-0003-3144-992X ; 0000-0003-4626-4645 ; 0000-0003-2424-2314 ; 0000-0002-3380-1192 ; 0000-0003-3098-8323 ; 0000-0003-4303-6006 ; 0000-0003-0164-6295</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629686/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629686/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39659832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanamori, Masayuki</creatorcontrib><creatorcontrib>Tsuzuki, Shunsuke</creatorcontrib><creatorcontrib>Shibahara, Ichiyo</creatorcontrib><creatorcontrib>Saito, Kuniaki</creatorcontrib><creatorcontrib>Shimoda, Yoshiteru</creatorcontrib><creatorcontrib>Tanaka, Kazuhiro</creatorcontrib><creatorcontrib>Yamaguchi, Shigeru</creatorcontrib><creatorcontrib>Natsumeda, Manabu</creatorcontrib><creatorcontrib>Matsutani, Tomoo</creatorcontrib><creatorcontrib>Hanihara, Mitsuto</creatorcontrib><creatorcontrib>Nakada, Mitsutoshi</creatorcontrib><creatorcontrib>Kuroda, Jun-Ichiro</creatorcontrib><creatorcontrib>Matsuda, Masahide</creatorcontrib><creatorcontrib>Yoshimoto, Koji</creatorcontrib><creatorcontrib>Yonezawa, Ushio</creatorcontrib><creatorcontrib>Sonoda, Yukihiko</creatorcontrib><creatorcontrib>Takano, Koji</creatorcontrib><creatorcontrib>Yonezawa, Hajime</creatorcontrib><creatorcontrib>Otani, Yoshihiro</creatorcontrib><creatorcontrib>Nakahara, Yukiko</creatorcontrib><creatorcontrib>Uchida, Masashi</creatorcontrib><creatorcontrib>Nonaka, Masahiro</creatorcontrib><creatorcontrib>Mineharu, Yohei</creatorcontrib><creatorcontrib>Kitamura, Yohei</creatorcontrib><creatorcontrib>Yamashita, Shinji</creatorcontrib><creatorcontrib>Yamauchi, Takahiro</creatorcontrib><creatorcontrib>Miyake, Yohei</creatorcontrib><creatorcontrib>Deguchi, Shoichi</creatorcontrib><creatorcontrib>Beppu, Takaaki</creatorcontrib><creatorcontrib>Tamura, Kaoru</creatorcontrib><creatorcontrib>Koizumi, Shinichiro</creatorcontrib><creatorcontrib>Hirose, Yuichi</creatorcontrib><creatorcontrib>Asano, Kenichiro</creatorcontrib><creatorcontrib>Hiruta, Ryo</creatorcontrib><creatorcontrib>Kinoshita, Manabu</creatorcontrib><creatorcontrib>Miyake, Keisuke</creatorcontrib><creatorcontrib>Nakayama, Noriyuki</creatorcontrib><creatorcontrib>Inoue, Akihiro</creatorcontrib><creatorcontrib>Ono, Takahiro</creatorcontrib><creatorcontrib>Sasaki, Takahiro</creatorcontrib><creatorcontrib>Akiyama, Yukinori</creatorcontrib><creatorcontrib>Fukami, Shinjiro</creatorcontrib><creatorcontrib>Yoshino, Atsuo</creatorcontrib><creatorcontrib>Kawanishi, Yu</creatorcontrib><creatorcontrib>Asanome, Taku</creatorcontrib><creatorcontrib>Yamaguchi, Takuhiro</creatorcontrib><creatorcontrib>Takahashi, Masamichi</creatorcontrib><creatorcontrib>Yamasaki, Fumiyuki</creatorcontrib><creatorcontrib>Arakawa, Yoshiki</creatorcontrib><creatorcontrib>Narita, Yoshitaka</creatorcontrib><title>Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study</title><title>Neuro-oncology advances</title><addtitle>Neurooncol Adv</addtitle><description>The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese patients who meet the EF-14 inclusion criteria.
This was a multicenter retrospective cohort study. Background, treatment, and outcome data of patients who satisfied the inclusion criteria of the EF-14 trial were collected from 45 institutions across Japan. The rate, determinants, and current status of TTField use, including its safety and efficacy in terms of progression and survival, were retrospectively investigated. This study was conducted in accordance with the STROBE checklist.
Among the 607 patients enrolled, 70 were excluded due to progressive disease during radiation and temozolomide therapy, age > 80 years old, and Karnofsky Performance Status score of <70. Among the remaining 537 patients, 210 (39%) underwent TTField treatment. Multivariate analysis revealed younger age and spouse as a caregiver as significant factors for TTField use. The compliance rate of TTField use exceeded 75% in 60% of patients, with a median TTField usage duration of 11 months. Skin disorders requiring medical treatment occurred in 56% of patients. Multivariate Cox proportional hazards analysis in the whole series and propensity score-matched analysis revealed that TTField use was not a prognostic factor for progression-free survival (PFS) or overall survival (OS).
TTField use did not have a substantial effect on either PFS or OS in Japanese patients with glioblastoma, despite compliance rates comparable to those observed in the EF-14.</description><subject>Clinical Investigations</subject><issn>2632-2498</issn><issn>2632-2498</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkU1v1DAQhiMEaqvSa4_IRw6ktR3bsbmgqoJSVIkLnC3Hnuy6cuJgO6n2Z_CPyWq3VTnNSPPMOx9vVV0SfEWwaq7HaB7HcL04A6QVb6ozKhpaU6bk21f5aXWR8yPGmHLGGaYn1WmjBFeyoWfV3_thMrag2KMyDzHVJYEpftyg3kNwGcURlS2gPKfFLybswR9mMiNkQNNKwlgyevJli0Z4CjvkvNmMMYNDm-BjF0wucTCf0Q0a5lC8XXlIn1CCkmKewBa_ALJxG1NBucxu975615uQ4eIYz6vf377-uv1eP_y8u7-9eagtbUWpTc8JcYR1gjmnutZ0mKlGWqmYtYy0mOG-5Rx6Iy3GPXRd37FW8oYr17aKNefVl4PuNHcDuP1iyQQ9JT-YtNPReP1_ZfRbvYmLJkRQJaRYFT4eFVL8M0MuevDZQgjrd-KcdUOYEFTyVq7o1QG169U5Qf8yh2C991IfvNRHL9eGD6-3e8GfnWv-Aasmogs</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Kanamori, 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Shinjiro</au><au>Yoshino, Atsuo</au><au>Kawanishi, Yu</au><au>Asanome, Taku</au><au>Yamaguchi, Takuhiro</au><au>Takahashi, Masamichi</au><au>Yamasaki, Fumiyuki</au><au>Arakawa, Yoshiki</au><au>Narita, Yoshitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study</atitle><jtitle>Neuro-oncology advances</jtitle><addtitle>Neurooncol Adv</addtitle><date>2024-01</date><risdate>2024</risdate><volume>6</volume><issue>1</issue><spage>vdae176</spage><pages>vdae176-</pages><issn>2632-2498</issn><eissn>2632-2498</eissn><abstract>The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese patients who meet the EF-14 inclusion criteria.
This was a multicenter retrospective cohort study. Background, treatment, and outcome data of patients who satisfied the inclusion criteria of the EF-14 trial were collected from 45 institutions across Japan. The rate, determinants, and current status of TTField use, including its safety and efficacy in terms of progression and survival, were retrospectively investigated. This study was conducted in accordance with the STROBE checklist.
Among the 607 patients enrolled, 70 were excluded due to progressive disease during radiation and temozolomide therapy, age > 80 years old, and Karnofsky Performance Status score of <70. Among the remaining 537 patients, 210 (39%) underwent TTField treatment. Multivariate analysis revealed younger age and spouse as a caregiver as significant factors for TTField use. The compliance rate of TTField use exceeded 75% in 60% of patients, with a median TTField usage duration of 11 months. Skin disorders requiring medical treatment occurred in 56% of patients. Multivariate Cox proportional hazards analysis in the whole series and propensity score-matched analysis revealed that TTField use was not a prognostic factor for progression-free survival (PFS) or overall survival (OS).
TTField use did not have a substantial effect on either PFS or OS in Japanese patients with glioblastoma, despite compliance rates comparable to those observed in the EF-14.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>39659832</pmid><doi>10.1093/noajnl/vdae176</doi><orcidid>https://orcid.org/0000-0003-3144-992X</orcidid><orcidid>https://orcid.org/0000-0003-4626-4645</orcidid><orcidid>https://orcid.org/0000-0003-2424-2314</orcidid><orcidid>https://orcid.org/0000-0002-3380-1192</orcidid><orcidid>https://orcid.org/0000-0003-3098-8323</orcidid><orcidid>https://orcid.org/0000-0003-4303-6006</orcidid><orcidid>https://orcid.org/0000-0003-0164-6295</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2632-2498 |
| ispartof | Neuro-oncology advances, 2024-01, Vol.6 (1), p.vdae176 |
| issn | 2632-2498 2632-2498 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11629686 |
| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Clinical Investigations |
| title | Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T17%3A50%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20tumor-treating%20fields%20on%20the%20survival%20of%20Japanese%20patients%20with%20newly%20diagnosed%20glioblastoma:%20A%20multicenter,%20retrospective%20cohort%20study&rft.jtitle=Neuro-oncology%20advances&rft.au=Kanamori,%20Masayuki&rft.date=2024-01&rft.volume=6&rft.issue=1&rft.spage=vdae176&rft.pages=vdae176-&rft.issn=2632-2498&rft.eissn=2632-2498&rft_id=info:doi/10.1093/noajnl/vdae176&rft_dat=%3Cproquest_pubme%3E3146628578%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3146628578&rft_id=info:pmid/39659832&rfr_iscdi=true |