Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct
Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyri...
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| Veröffentlicht in: | Biochemical journal 1981-06, Vol.195 (3), p.761-764 |
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| container_title | Biochemical journal |
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| creator | Ortiz de Montellano, P R Mathews, J M |
| description | Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem. |
| doi_str_mv | 10.1042/bj1950761 |
| format | Article |
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An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj1950761</identifier><identifier>PMID: 7316983</identifier><language>eng</language><publisher>England</publisher><subject>Alkylation ; Animals ; Cytochrome P-450 Enzyme Inhibitors ; Cytochromes - metabolism ; Cytochromes b5 ; Heme - metabolism ; In Vitro Techniques ; Macromolecular Substances ; Male ; Microsomes, Liver - drug effects ; Microsomes, Liver - enzymology ; Protoporphyrins - isolation & purification ; Rats ; Rats, Inbred Strains ; Spectrophotometry ; Triazoles - pharmacology</subject><ispartof>Biochemical journal, 1981-06, Vol.195 (3), p.761-764</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3511-8686f5d01d3fba828284709140bba74a07648b1e3bf67cb2dcde2a2399b57bf33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1162949/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1162949/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7316983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortiz de Montellano, P R</creatorcontrib><creatorcontrib>Mathews, J M</creatorcontrib><title>Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. 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| fulltext | fulltext |
| identifier | ISSN: 0264-6021 |
| ispartof | Biochemical journal, 1981-06, Vol.195 (3), p.761-764 |
| issn | 0264-6021 1470-8728 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1162949 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alkylation Animals Cytochrome P-450 Enzyme Inhibitors Cytochromes - metabolism Cytochromes b5 Heme - metabolism In Vitro Techniques Macromolecular Substances Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Protoporphyrins - isolation & purification Rats Rats, Inbred Strains Spectrophotometry Triazoles - pharmacology |
| title | Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct |
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