Specific features of ß-catenin-mutated hepatocellular carcinomas

CTNNB1, encoding the ß-catenin protein, is a key oncogene contributing to liver carcinogenesis. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adult, representing the third leading cause of cancer-related death. Aberrant activation of the Wnt/ß-catenin pathway, mai...

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Veröffentlicht in:	British journal of cancer 2024-12, Vol.131 (12), p.1871-1880
Hauptverfasser:	Dantzer, Camille, Dif, Lydia, Vaché, Justine, Basbous, Sara, Billottet, Clotilde, Moreau, Violaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults beta Catenin - genetics Carcinogenesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell differentiation Cell growth Cell proliferation Cholestasis CTNNB1 gene Drug development Gene expression Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Medical innovations Mortality Mutation Review Tumors Wnt protein Wnt Signaling Pathway - genetics β-Catenin
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